Interactive version of Figure 4. Shift-click to get more information about a gene. Your browser must support Java 1.4 or better. If you cannot see the applet at all, popups may be disabled.
Figure 4. Major component of a literature derived protein interaction subnetwork, obtained from the String database at a reliability score of at least 0.3 (von Mering et al., 2005). It reveals that several well known interacting proteins also show similar expression profiles. Examples are the highlighted vacuolar ATPases, the Proteasome, or interactors of Peter Pan. Notch appears as central node of the network and contributes to the high interconnectivity of the (transient) class II:a group.. Some genes with expression profiles very similar to notch (labeled by red arrows) are currently only loosely associated with the pathway (see text), but might share more functionality with notch than previously thought. Notch is labeled for reference purposes. Note that unassigned in the legend means that the respective genes belong to the class but not to any of the major subclasses. See the manuscript for more information.