@article{Hallem.2011.21173231,
  author = {Hallem, EA and Spencer, WC and McWhirter, RD and Zeller, G and Henz, SR and Rätsch, G and Miller, DM and Horvitz, HR and Sternberg, PW and Ringstad, N},
  title = {{Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  volume = {108},
  number = {1},
  pages = {254-9},
  year = {2011},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/21173231},
  abstract = {{CO(2) is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO(2) avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO(2) specifically activates the BAG neurons and that the CO(2)-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO(2) sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO(2).}}
}