# Table of high-confidence word-OG associations # ----------------------------------------------- # (results for hyperthermophily and sporulation # have been refined, as discussed in the text. # Prior to clustering, associations with scores # below the high-confidence threshold were removed.) # # # association_score word - OG OG_annotation # Cluster 1 ----------------------------------------------------------- 0.812172 vacuum - COG3933 Transcriptional antiterminator 0.808278 sausage - COG4869 Propanediol utilization protein 0.798838 monocytogene - NOG08857 non supervised orthologous group 0.798619 starter - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.789747 starter - NOG08391 non supervised orthologous group 0.785647 vacuum - COG4869 Propanediol utilization protein 0.783999 starter - COG4909 Propanediol dehydratase, large subunit 0.783999 starter - COG4910 Propanediol dehydratase, small subunit 0.782693 sausage - COG4910 Propanediol dehydratase, small subunit 0.782693 sausage - COG4909 Propanediol dehydratase, large subunit 0.778675 bacteriocins - COG4905 Predicted membrane protein 0.774567 starter - COG4869 Propanediol utilization protein 0.773429 vegetable - COG4869 Propanediol utilization protein 0.754735 starter - COG4905 Predicted membrane protein 0.751404 bacteriocins - NOG08391 non supervised orthologous group 0.748810 sausage - COG3933 Transcriptional antiterminator 0.743894 lecithinase - COG4769 Predicted membrane protein 0.741232 spoilage - COG3933 Transcriptional antiterminator 0.740472 lecithinase - COG5341 Uncharacterized protein conserved in bacteria 0.740350 lecithinase - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.734639 sausage - NOG08391 non supervised orthologous group 0.730139 vacuum - COG4909 Propanediol dehydratase, large subunit 0.730139 vacuum - COG4910 Propanediol dehydratase, small subunit 0.729636 cheese - COG4194 Predicted membrane protein 0.727019 sausage - NOG08857 non supervised orthologous group 0.726603 vegetable - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.726497 starter - COG4769 Predicted membrane protein 0.725313 bacteriocins - COG4910 Propanediol dehydratase, small subunit 0.725313 bacteriocins - COG4909 Propanediol dehydratase, large subunit 0.723889 enteritidis - COG4917 Ethanolamine utilization protein 0.723889 enteritidis - COG4816 Ethanolamine utilization protein 0.723889 enteritidis - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.723889 enteritidis - COG4810 Ethanolamine utilization protein 0.723044 enteritidis - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.722868 vacuum - NOG08391 non supervised orthologous group 0.722192 vegetable - COG4910 Propanediol dehydratase, small subunit 0.722192 vegetable - COG4909 Propanediol dehydratase, large subunit 0.722150 vacuum - COG4194 Predicted membrane protein 0.720872 starter - COG5341 Uncharacterized protein conserved in bacteria 0.719837 lecithinase - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.718706 bacteriocins - COG4832 Uncharacterized conserved protein 0.717487 bacteriocins - COG4194 Predicted membrane protein 0.717385 starter - COG3933 Transcriptional antiterminator 0.715636 monocytogene - COG4869 Propanediol utilization protein 0.715598 bacteriocins - COG5341 Uncharacterized protein conserved in bacteria 0.714275 spoilage - COG4194 Predicted membrane protein 0.713687 enteritidis - COG4869 Propanediol utilization protein 0.710021 cheese - COG4869 Propanediol utilization protein 0.708053 bacteriocins - COG4769 Predicted membrane protein 0.707201 starter - NOG26407 non supervised orthologous group 0.706186 spoilage - COG4869 Propanediol utilization protein 0.705676 vegetable - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.705676 vegetable - COG4810 Ethanolamine utilization protein 0.705676 vegetable - COG4917 Ethanolamine utilization protein 0.705676 vegetable - COG4816 Ethanolamine utilization protein 0.704793 bacteriocins - COG4869 Propanediol utilization protein 0.704097 bacteriocins - COG3933 Transcriptional antiterminator 0.703438 bacteriocin - COG4905 Predicted membrane protein 0.703413 monocytogene - COG3933 Transcriptional antiterminator 0.702468 lactobacillus - COG4194 Predicted membrane protein 0.701570 vegetable - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.700063 sausage - COG4769 Predicted membrane protein 0.697561 bacteriocins - COG3580 Uncharacterized protein conserved in bacteria 0.696646 sausage - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.696048 starter - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.695491 sausage - COG5341 Uncharacterized protein conserved in bacteria 0.693921 sausage - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.693920 sausage - COG4905 Predicted membrane protein 0.693894 vacuum - COG3426 Butyrate kinase 0.692620 spoilage - COG4769 Predicted membrane protein 0.691364 monocytogene - COG4909 Propanediol dehydratase, large subunit 0.691364 monocytogene - COG4910 Propanediol dehydratase, small subunit 0.691261 lecithinase - COG3581 Uncharacterized protein conserved in bacteria 0.689447 abortion - NOG08391 non supervised orthologous group 0.688565 vegetable - COG3592 Uncharacterized conserved protein 0.685536 vegetable - COG3933 Transcriptional antiterminator 0.683912 lecithinase - COG3426 Butyrate kinase 0.682921 spoilage - COG3426 Butyrate kinase 0.682655 cheese - NOG08857 non supervised orthologous group 0.682289 spoilage - COG5341 Uncharacterized protein conserved in bacteria 0.681854 lecithinase - COG3872 Predicted metal-dependent enzyme 0.680261 starter - COG4832 Uncharacterized conserved protein 0.679443 sausage - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.678769 sausage - NOG26407 non supervised orthologous group 0.678184 vacuum - COG3192 Ethanolamine utilization protein 0.673026 gastroenteritis - COG4816 Ethanolamine utilization protein 0.673026 gastroenteritis - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.673026 gastroenteritis - COG4917 Ethanolamine utilization protein 0.673026 gastroenteritis - COG4810 Ethanolamine utilization protein 0.672159 spoilage - NOG08391 non supervised orthologous group 0.671601 starter - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.668987 bacteriocins - NOG26407 non supervised orthologous group 0.668530 spoilage - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.667931 bacteriocin - COG5341 Uncharacterized protein conserved in bacteria 0.667873 sausage - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.667873 sausage - COG4917 Ethanolamine utilization protein 0.667873 sausage - COG4810 Ethanolamine utilization protein 0.667873 sausage - COG4816 Ethanolamine utilization protein 0.667685 vacuum - COG4769 Predicted membrane protein 0.666502 monocytogene - COG4194 Predicted membrane protein 0.666345 vegetable - NOG08391 non supervised orthologous group 0.666327 bacteriocin - COG3580 Uncharacterized protein conserved in bacteria 0.665752 bacteriocins - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.665295 gastroenteritis - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.664461 starter - COG3592 Uncharacterized conserved protein 0.664266 vacuum - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.659681 sausage - NOG26249 non supervised orthologous group 0.659193 sausage - COG3592 Uncharacterized conserved protein 0.658932 bacteriocins - COG3581 Uncharacterized protein conserved in bacteria 0.658548 vacuum - COG5341 Uncharacterized protein conserved in bacteria 0.658542 bacteriocins - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.657748 starter - COG3580 Uncharacterized protein conserved in bacteria 0.657640 cheese - COG3933 Transcriptional antiterminator 0.657325 bacteriocin - COG4769 Predicted membrane protein 0.657234 cheese - NOG08391 non supervised orthologous group 0.655594 spoilage - COG3872 Predicted metal-dependent enzyme 0.655282 abortion - COG4869 Propanediol utilization protein 0.654747 vacuum - COG4905 Predicted membrane protein 0.654743 cheese - COG4909 Propanediol dehydratase, large subunit 0.654743 cheese - COG4910 Propanediol dehydratase, small subunit 0.654427 enteritidis - NOG08857 non supervised orthologous group 0.654097 abortion - COG4769 Predicted membrane protein 0.653763 bacteriocin - NOG08391 non supervised orthologous group 0.652875 vacuum - COG3584 Uncharacterized protein conserved in bacteria 0.650313 monocytogene - COG4905 Predicted membrane protein 0.649747 abortion - NOG08857 non supervised orthologous group 0.649306 sausage - COG4834 Uncharacterized protein conserved in bacteria 0.649128 sausage - COG3580 Uncharacterized protein conserved in bacteria 0.649015 vacuum - COG3872 Predicted metal-dependent enzyme 0.648829 bacteriocin - COG4194 Predicted membrane protein 0.647382 vacuum - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.646168 starter - COG4194 Predicted membrane protein 0.644878 bacteriocin - COG3581 Uncharacterized protein conserved in bacteria 0.642771 vegetable - COG3732 Phosphotransferase system sorbitol-specific component IIBC 0.642525 monocytogene - COG4834 Uncharacterized protein conserved in bacteria 0.642263 vegetable - COG3730 Phosphotransferase system sorbitol-specific component IIC 0.642023 spoilage - COG4905 Predicted membrane protein 0.641821 serovars - NOG08857 non supervised orthologous group 0.641516 starter - COG4816 Ethanolamine utilization protein 0.641516 starter - COG4810 Ethanolamine utilization protein 0.641516 starter - COG4917 Ethanolamine utilization protein 0.641516 starter - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.641193 capsid - COG4194 Predicted membrane protein 0.640239 phospholipase - COG4769 Predicted membrane protein 0.640053 spoilage - COG3580 Uncharacterized protein conserved in bacteria 0.639790 vacuum - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.639343 denitrificans - COG4194 Predicted membrane protein 0.638165 sausage - COG4194 Predicted membrane protein 0.637864 carcass - COG4869 Propanediol utilization protein 0.636102 gastroenteritis - COG4869 Propanediol utilization protein 0.634426 spoilage - COG3581 Uncharacterized protein conserved in bacteria 0.634168 spoilage - COG4910 Propanediol dehydratase, small subunit 0.634168 spoilage - COG4909 Propanediol dehydratase, large subunit 0.633783 lecithinase - NOG08391 non supervised orthologous group 0.633180 lecithinase - COG3580 Uncharacterized protein conserved in bacteria 0.632359 starter - COG3581 Uncharacterized protein conserved in bacteria 0.631886 vegetable - COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.630511 lecithinase - COG4905 Predicted membrane protein 0.630252 vegetable - COG3731 Phosphotransferase system sorbitol-specific component IIA 0.629962 broiler - COG4769 Predicted membrane protein 0.628931 monocytogene - COG4832 Uncharacterized conserved protein 0.625984 serovar - COG2918 Gamma-glutamylcysteine synthetase 0.625273 gastroenteritis - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.624196 lecithinase - COG3933 Transcriptional antiterminator 0.623965 starter - COG4834 Uncharacterized protein conserved in bacteria 0.623937 phospholipase - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.623572 phospholipase - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.623478 cheese - COG4905 Predicted membrane protein 0.623063 serovar - NOG08857 non supervised orthologous group 0.621736 abortion - COG5341 Uncharacterized protein conserved in bacteria 0.621659 enteritidis - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.621472 cytosol - COG4272 Predicted membrane protein 0.621301 sewage - COG4194 Predicted membrane protein 0.621166 vegetable - COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.621126 monocytogene - NOG08391 non supervised orthologous group 0.620860 sausage - COG4832 Uncharacterized conserved protein 0.619708 serovar - COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC 0.619542 enteritidis - COG4910 Propanediol dehydratase, small subunit 0.619542 enteritidis - COG4909 Propanediol dehydratase, large subunit 0.619218 phospholipase - COG5341 Uncharacterized protein conserved in bacteria 0.617525 bacteriocins - NOG08857 non supervised orthologous group 0.617380 sausage - COG4272 Predicted membrane protein 0.616982 broiler - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.615025 vegetable - COG3192 Ethanolamine utilization protein 0.614571 monocytogene - NOG26249 non supervised orthologous group 0.613868 coliforms - COG4194 Predicted membrane protein 0.613175 spoilage - COG3584 Uncharacterized protein conserved in bacteria 0.613058 enteritidis - COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.612642 abortion - COG3933 Transcriptional antiterminator Cluster 2 ----------------------------------------------------------- 0.808369 flagellin - COG1684 Flagellar biosynthesis pathway, component FliR 0.808369 flagellin - COG1987 Flagellar biosynthesis pathway, component FliQ 0.808369 flagellin - COG1868 Flagellar motor switch protein 0.808369 flagellin - COG1677 Flagellar hook-basal body protein 0.808369 flagellin - COG4786 Flagellar basal body rod protein 0.808369 flagellin - COG1815 Flagellar basal body protein 0.808369 flagellin - COG1843 Flagellar hook capping protein 0.806560 flagellin - COG1291 Flagellar motor component 0.806560 flagellin - COG1344 Flagellin and related hook-associated proteins 0.806560 flagellin - COG1360 Flagellar motor protein 0.800634 flagellin - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.800634 flagellin - COG1558 Flagellar basal body rod protein 0.792643 flagellin - COG1256 Flagellar hook-associated protein 0.791480 flagellum - COG1684 Flagellar biosynthesis pathway, component FliR 0.791480 flagellum - COG1677 Flagellar hook-basal body protein 0.791480 flagellum - COG1868 Flagellar motor switch protein 0.791480 flagellum - COG1843 Flagellar hook capping protein 0.791480 flagellum - COG4786 Flagellar basal body rod protein 0.791480 flagellum - COG1815 Flagellar basal body protein 0.791480 flagellum - COG1987 Flagellar biosynthesis pathway, component FliQ 0.789336 flagellum - COG1360 Flagellar motor protein 0.789336 flagellum - COG1291 Flagellar motor component 0.789336 flagellum - COG1344 Flagellin and related hook-associated proteins 0.788505 flagellum - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.788505 flagellum - COG1558 Flagellar basal body rod protein 0.766970 flagellum - COG1256 Flagellar hook-associated protein 0.751754 flagellin - COG1516 Flagellin-specific chaperone FliS 0.751754 flagellin - COG1345 Flagellar capping protein 0.733530 flagellin - COG1749 Flagellar hook protein FlgE 0.718323 flagellin - COG1338 Flagellar biosynthesis pathway, component FliP 0.718323 flagellin - COG1157 Flagellar biosynthesis/type III secretory pathway ATPase 0.718323 flagellin - COG1377 Flagellar biosynthesis pathway, component FlhB 0.718323 flagellin - COG1298 Flagellar biosynthesis pathway, component FlhA 0.711255 flagellin - COG1886 Flagellar motor switch/type III secretory pathway protein 0.703436 flagellum - COG1345 Flagellar capping protein 0.703436 flagellum - COG1516 Flagellin-specific chaperone FliS 0.697821 flagellin - COG1536 Flagellar motor switch protein 0.693395 sewage - COG1749 Flagellar hook protein FlgE 0.691695 flagellum - COG1749 Flagellar hook protein FlgE 0.682291 flagellum - COG1338 Flagellar biosynthesis pathway, component FliP 0.682291 flagellum - COG1377 Flagellar biosynthesis pathway, component FlhB 0.682291 flagellum - COG1298 Flagellar biosynthesis pathway, component FlhA 0.682291 flagellum - COG1157 Flagellar biosynthesis/type III secretory pathway ATPase 0.672903 flagellin - COG1419 Flagellar GTP-binding protein 0.667790 motility - COG1684 Flagellar biosynthesis pathway, component FliR 0.667790 motility - COG1868 Flagellar motor switch protein 0.667790 motility - COG4786 Flagellar basal body rod protein 0.667790 motility - COG1677 Flagellar hook-basal body protein 0.667790 motility - COG1815 Flagellar basal body protein 0.667790 motility - COG1843 Flagellar hook capping protein 0.667790 motility - COG1987 Flagellar biosynthesis pathway, component FliQ 0.663896 motility - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.663896 motility - COG1558 Flagellar basal body rod protein 0.658064 vegetable - COG1749 Flagellar hook protein FlgE 0.653167 sewage - COG1684 Flagellar biosynthesis pathway, component FliR 0.653167 sewage - COG1987 Flagellar biosynthesis pathway, component FliQ 0.653167 sewage - COG1868 Flagellar motor switch protein 0.653167 sewage - COG4786 Flagellar basal body rod protein 0.653167 sewage - COG1815 Flagellar basal body protein 0.653167 sewage - COG1843 Flagellar hook capping protein 0.653167 sewage - COG1677 Flagellar hook-basal body protein 0.651899 motility - COG1256 Flagellar hook-associated protein 0.651062 flagellum - COG1536 Flagellar motor switch protein 0.648977 flagellum - COG1886 Flagellar motor switch/type III secretory pathway protein 0.646570 sewage - COG1558 Flagellar basal body rod protein 0.646570 sewage - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.645663 flagellum - COG1706 Flagellar basal-body P-ring protein 0.641991 flagellum - COG1419 Flagellar GTP-binding protein 0.640902 sewage - COG1360 Flagellar motor protein 0.640902 sewage - COG1291 Flagellar motor component 0.640902 sewage - COG1344 Flagellin and related hook-associated proteins 0.637074 flagellum - COG1261 Flagellar basal body P-ring biosynthesis protein 0.637074 flagellum - COG2063 Flagellar basal body L-ring protein 0.636647 motility - COG1749 Flagellar hook protein FlgE 0.634989 flagellum - COG0835 Chemotaxis signal transduction protein 0.629791 flagellin - COG0835 Chemotaxis signal transduction protein 0.629443 flagellum - COG0643 Chemotaxis protein histidine kinase and related kinases 0.627454 motility - COG1291 Flagellar motor component 0.627454 motility - COG1344 Flagellin and related hook-associated proteins 0.627454 motility - COG1360 Flagellar motor protein 0.625562 sewage - COG1345 Flagellar capping protein 0.625562 sewage - COG1516 Flagellin-specific chaperone FliS 0.623485 flagellin - COG0643 Chemotaxis protein histidine kinase and related kinases 0.618740 flagellum - COG1580 Flagellar basal body-associated protein 0.618472 sewage - COG1256 Flagellar hook-associated protein 0.616952 flagellin - COG1706 Flagellar basal-body P-ring protein 0.612868 flagellin - COG1261 Flagellar basal body P-ring biosynthesis protein 0.612868 flagellin - COG2063 Flagellar basal body L-ring protein Cluster 3 ----------------------------------------------------------- 0.807206 difficile - NOG09246 non supervised orthologous group 0.767427 metronidazole - NOG19912 non supervised orthologous group 0.749042 difficile - NOG28580 non supervised orthologous group 0.737211 difficile - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.734765 difficile - NOG19912 non supervised orthologous group 0.732521 difficile - COG3877 Uncharacterized protein conserved in bacteria 0.719341 difficile - COG1655 Uncharacterized protein conserved in bacteria 0.718836 cytotoxin - NOG19912 non supervised orthologous group 0.708965 difficile - COG1433 Uncharacterized conserved protein 0.704578 metronidazole - NOG09246 non supervised orthologous group 0.698020 difficile - COG3968 Uncharacterized protein related to glutamine synthetase 0.696191 antitoxin - NOG09246 non supervised orthologous group 0.690932 difficile - COG1243 Histone acetyltransferase 0.682126 difficile - COG3862 Uncharacterized protein with conserved CXXC pairs 0.680499 difficile - COG1978 Uncharacterized protein conserved in bacteria 0.680182 difficile - COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.679867 antitoxin - COG1433 Uncharacterized conserved protein 0.676715 enterocolitis - NOG09246 non supervised orthologous group 0.676666 difficile - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.660442 antitoxin - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.651699 enterocolitis - COG3877 Uncharacterized protein conserved in bacteria 0.649666 enterocolitis - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.648991 colitis - NOG19912 non supervised orthologous group 0.640913 enterocolitis - COG1151 6Fe-6S prismane cluster-containing protein 0.636919 metronidazole - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.636573 enteritis - NOG19912 non supervised orthologous group 0.636077 metronidazole - COG3877 Uncharacterized protein conserved in bacteria 0.635967 antitoxin - COG1243 Histone acetyltransferase 0.630420 enterocolitis - COG3968 Uncharacterized protein related to glutamine synthetase 0.624169 stomach - NOG19912 non supervised orthologous group 0.624080 metronidazole - COG1655 Uncharacterized protein conserved in bacteria 0.621315 antitoxin - NOG28580 non supervised orthologous group 0.620466 metronidazole - COG3968 Uncharacterized protein related to glutamine synthetase 0.619487 enterocolitis - COG3862 Uncharacterized protein with conserved CXXC pairs 0.616846 enterocolitis - NOG28580 non supervised orthologous group 0.612529 colitis - COG1655 Uncharacterized protein conserved in bacteria Cluster 4 ----------------------------------------------------------- 0.807042 transferrin - COG3219 Uncharacterized protein conserved in bacteria 0.791836 lipooligosaccharide - COG3524 Capsule polysaccharide export protein 0.784464 lipooligosaccharide - COG3562 Capsule polysaccharide export protein 0.784464 lipooligosaccharide - COG3563 Capsule polysaccharide export protein 0.778153 postvaccination - COG3219 Uncharacterized protein conserved in bacteria 0.778143 lipooligosaccharide - COG2830 Uncharacterized protein conserved in bacteria 0.778121 lipooligosaccharide - COG3219 Uncharacterized protein conserved in bacteria 0.770996 lipooligosaccharides - COG3563 Capsule polysaccharide export protein 0.770996 lipooligosaccharides - COG3562 Capsule polysaccharide export protein 0.770463 lipooligosaccharides - COG3219 Uncharacterized protein conserved in bacteria 0.770055 lipooligosaccharides - COG3524 Capsule polysaccharide export protein 0.750062 postvaccination - COG3562 Capsule polysaccharide export protein 0.750062 postvaccination - COG3563 Capsule polysaccharide export protein 0.749473 postvaccination - COG2830 Uncharacterized protein conserved in bacteria 0.747886 postvaccination - COG3524 Capsule polysaccharide export protein 0.743431 multilocus - COG3779 Uncharacterized protein conserved in bacteria 0.742994 transferrin - COG2830 Uncharacterized protein conserved in bacteria 0.742421 lipooligosaccharides - COG2830 Uncharacterized protein conserved in bacteria 0.742396 transferrin - COG3778 Uncharacterized protein conserved in bacteria 0.734457 vaccinees - COG3778 Uncharacterized protein conserved in bacteria 0.729867 transferrin - COG3767 Uncharacterized low-complexity protein 0.713437 multilocus - COG4797 Predicted regulatory domain of a methyltransferase 0.702567 multilocus - COG2852 Uncharacterized protein conserved in bacteria 0.692605 vaccinees - COG3203 Outer membrane protein (porin) 0.692068 postvaccination - COG2965 Primosomal replication protein N 0.689694 meningitis - COG3219 Uncharacterized protein conserved in bacteria 0.686638 vaccinees - COG5007 Predicted transcriptional regulator, BolA superfamily 0.684455 transferrin - COG3524 Capsule polysaccharide export protein 0.683441 transferrin - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.682913 multilocus - COG3563 Capsule polysaccharide export protein 0.682913 multilocus - COG3562 Capsule polysaccharide export protein 0.681863 multilocus - COG3524 Capsule polysaccharide export protein 0.680552 multilocus - COG2830 Uncharacterized protein conserved in bacteria 0.679436 transferrin - COG3563 Capsule polysaccharide export protein 0.679436 transferrin - COG3562 Capsule polysaccharide export protein 0.678423 vaccinees - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.674737 lipooligosaccharide - COG4797 Predicted regulatory domain of a methyltransferase 0.674154 transferrin - COG5007 Predicted transcriptional regulator, BolA superfamily 0.673030 transferrin - COG2965 Primosomal replication protein N 0.672436 purpura - COG3692 Uncharacterized protein conserved in bacteria 0.672394 lipooligosaccharide - COG3767 Uncharacterized low-complexity protein 0.668871 transferrin - COG3203 Outer membrane protein (porin) 0.667361 multilocus - COG2965 Primosomal replication protein N 0.666090 lipooligosaccharides - COG3767 Uncharacterized low-complexity protein 0.663629 postvaccination - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.660058 lipooligosaccharide - COG3453 Uncharacterized protein conserved in bacteria 0.656626 transferrin - COG3171 Uncharacterized protein conserved in bacteria 0.656600 lipooligosaccharides - COG4797 Predicted regulatory domain of a methyltransferase 0.656562 lipooligosaccharide - COG2965 Primosomal replication protein N 0.655564 multilocus - COG3219 Uncharacterized protein conserved in bacteria 0.653393 postvaccination - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.653045 vaccinees - COG2914 Uncharacterized protein conserved in bacteria 0.652966 transferrin - COG2995 Uncharacterized paraquat-inducible protein A 0.652799 toxoid - COG4942 Membrane-bound metallopeptidase 0.652750 postvaccination - COG3453 Uncharacterized protein conserved in bacteria 0.651916 postvaccination - COG2914 Uncharacterized protein conserved in bacteria 0.650539 postvaccination - COG3203 Outer membrane protein (porin) 0.649830 postvaccination - COG3767 Uncharacterized low-complexity protein 0.648713 transferrin - COG5339 putative exported or periplasmic protein (prev: Uncharacterized protein conserved in bacteria) 0.648384 postvaccination - COG4797 Predicted regulatory domain of a methyltransferase 0.648353 vaccinees - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.646817 transferrin - COG2990 Uncharacterized protein conserved in bacteria 0.644263 transferrin - COG3471 Predicted periplasmic/secreted protein 0.643406 purpura - COG4797 Predicted regulatory domain of a methyltransferase 0.640956 transferrin - COG4797 Predicted regulatory domain of a methyltransferase 0.639007 vaccinees - COG2913 Small protein A (tmRNA-binding) 0.638754 vaccinees - COG3063 Tfp pilus assembly protein PilF 0.638505 lipooligosaccharides - COG2965 Primosomal replication protein N 0.633605 fatality - COG3778 Uncharacterized protein conserved in bacteria 0.633301 vaccinees - COG2924 Fe-S cluster protector protein 0.633301 vaccinees - COG2976 Uncharacterized protein conserved in bacteria 0.633239 postvaccination - COG2995 Uncharacterized paraquat-inducible protein A 0.631219 meningitis - COG3767 Uncharacterized low-complexity protein 0.629219 meningitis - NOG14186 non supervised orthologous group 0.628168 lipooligosaccharides - COG3778 Uncharacterized protein conserved in bacteria 0.627999 postvaccination - COG2840 Uncharacterized protein conserved in bacteria 0.626669 transferrin - COG3317 Uncharacterized lipoprotein 0.626669 transferrin - COG3008 Paraquat-inducible protein B 0.626235 lipooligosaccharides - COG3453 Uncharacterized protein conserved in bacteria 0.626075 lipooligosaccharides - COG3779 Uncharacterized protein conserved in bacteria 0.625355 postvaccination - COG3113 Predicted NTP binding protein (contains STAS domain) 0.625355 postvaccination - COG2956 Predicted N-acetylglucosaminyl transferase 0.624114 fatality - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.623310 lipooligosaccharide - COG3778 Uncharacterized protein conserved in bacteria 0.622147 vaccinees - COG2901 Factor for inversion stimulation Fis, transcriptional activator 0.622147 vaccinees - COG2921 Uncharacterized conserved protein 0.621588 vaccinees - COG3219 Uncharacterized protein conserved in bacteria 0.621040 vaccinees - COG2840 Uncharacterized protein conserved in bacteria 0.620179 meningitis - COG3778 Uncharacterized protein conserved in bacteria 0.619384 postvaccination - COG3778 Uncharacterized protein conserved in bacteria 0.618093 vaccinees - COG1952 Preprotein translocase subunit SecB 0.616306 meningitis - COG5007 Predicted transcriptional regulator, BolA superfamily 0.616154 tetanus - COG3219 Uncharacterized protein conserved in bacteria 0.616046 meningitis - COG4797 Predicted regulatory domain of a methyltransferase 0.615988 chemoprophylaxis - COG3778 Uncharacterized protein conserved in bacteria 0.613942 transferrin - COG2914 Uncharacterized protein conserved in bacteria 0.613709 purpura - COG2830 Uncharacterized protein conserved in bacteria Cluster 5 ----------------------------------------------------------- 0.802693 vegetation - COG4413 Urea transporter 0.758817 silicone - COG4413 Urea transporter 0.744128 amikacin - COG4413 Urea transporter 0.707047 cornea - COG4413 Urea transporter 0.693175 implant - COG4413 Urea transporter 0.687709 prosthesis - COG4413 Urea transporter 0.683271 coagulase - COG4413 Urea transporter 0.673030 fibrosis - COG4413 Urea transporter 0.655227 gentamicin - COG4413 Urea transporter 0.653778 dermatitis - COG4413 Urea transporter 0.653192 osteomyelitis - COG4413 Urea transporter 0.637652 vegetation - COG3477 Predicted periplasmic/secreted protein 0.636546 ointment - COG4413 Urea transporter 0.632761 cefoperazone - COG4413 Urea transporter 0.629525 implant - COG1566 Multidrug resistance efflux pump 0.627687 osteomyelitis - COG1566 Multidrug resistance efflux pump Cluster 6 ----------------------------------------------------------- 0.801993 silicone - COG4270 Predicted membrane protein 0.758432 device - COG4270 Predicted membrane protein 0.729488 implant - COG4270 Predicted membrane protein 0.720146 cornea - COG4270 Predicted membrane protein 0.718603 silicone - COG3296 Uncharacterized protein conserved in bacteria 0.717438 osteomyelitis - COG4732 Predicted membrane protein 0.703326 implant - COG4495 Uncharacterized protein conserved in bacteria 0.693614 catheter - COG3002 Uncharacterized protein conserved in bacteria 0.686688 vegetation - COG4270 Predicted membrane protein 0.681770 implant - COG4732 Predicted membrane protein 0.679570 chlorhexidine - COG4270 Predicted membrane protein 0.679190 silicone - NOG07926 non supervised orthologous group 0.678242 prosthesis - COG4270 Predicted membrane protein 0.678158 silicone - NOG14978 non supervised orthologous group 0.671331 dermatitis - COG4270 Predicted membrane protein 0.669031 cornea - COG2314 Predicted membrane protein, and no convincing STRING links 0.665327 haemolyticus - COG4732 Predicted membrane protein 0.662391 implant - NOG14978 non supervised orthologous group 0.659804 catheter - COG4270 Predicted membrane protein 0.659307 prosthesis - COG3002 Uncharacterized protein conserved in bacteria 0.655460 cefazolin - COG4732 Predicted membrane protein 0.654286 prosthesis - COG4333 Uncharacterized protein conserved in bacteria 0.645016 silicone - COG3002 Uncharacterized protein conserved in bacteria 0.643491 implant - COG3002 Uncharacterized protein conserved in bacteria 0.642246 catheter - COG3296 Uncharacterized protein conserved in bacteria 0.642231 catheter - COG4732 Predicted membrane protein 0.641809 osteomyelitis - COG4495 Uncharacterized protein conserved in bacteria 0.641673 silicone - COG4495 Uncharacterized protein conserved in bacteria 0.641397 cornea - COG3296 Uncharacterized protein conserved in bacteria 0.640928 implant - COG4333 Uncharacterized protein conserved in bacteria 0.640493 silicone - COG2314 Predicted membrane protein, and no convincing STRING links 0.639205 silicone - COG2602 Beta-lactamase class D 0.637836 dermatitis - COG4732 Predicted membrane protein 0.636532 implant - NOG07926 non supervised orthologous group 0.636080 implant - COG3296 Uncharacterized protein conserved in bacteria 0.633486 prosthesis - NOG14978 non supervised orthologous group 0.633037 dermatitis - COG3002 Uncharacterized protein conserved in bacteria 0.632385 implantation - NOG07926 non supervised orthologous group 0.629548 device - COG2602 Beta-lactamase class D 0.628101 silicone - COG4333 Uncharacterized protein conserved in bacteria 0.627493 osteomyelitis - COG4270 Predicted membrane protein 0.625995 ointment - COG4270 Predicted membrane protein 0.623631 vegetation - COG3002 Uncharacterized protein conserved in bacteria 0.623387 dermatitis - NOG07935 non supervised orthologous group 0.623357 implantation - COG4270 Predicted membrane protein 0.617620 silicone - COG4732 Predicted membrane protein 0.617512 device - COG2314 Predicted membrane protein, and no convincing STRING links 0.615365 osteomyelitis - COG4333 Uncharacterized protein conserved in bacteria 0.613477 vegetation - COG4732 Predicted membrane protein 0.613028 coagulase - COG4732 Predicted membrane protein Cluster 7 ----------------------------------------------------------- 0.798477 chlorophyll - NOG09697 non supervised orthologous group 0.798477 chlorophyll - NOG14127 non supervised orthologous group 0.793777 cyanobacteria - NOG12317 non supervised orthologous group 0.793301 cyanobacteria - COG4995 Uncharacterized protein conserved in bacteria 0.788735 photosystem - COG4995 Uncharacterized protein conserved in bacteria 0.788313 photosynthesis - COG4995 Uncharacterized protein conserved in bacteria 0.785247 chlorophyll - NOG10341 non supervised orthologous group 0.779015 photosystem - NOG10341 non supervised orthologous group 0.778547 cyanobacteria - NOG10341 non supervised orthologous group 0.774722 flavodoxin - COG3330 Uncharacterized protein conserved in bacteria 0.772113 photosystem - NOG09697 non supervised orthologous group 0.772113 photosystem - NOG14127 non supervised orthologous group 0.767081 cyanobacteria - NOG09697 non supervised orthologous group 0.767081 cyanobacteria - NOG14127 non supervised orthologous group 0.765686 photosynthesis - NOG10341 non supervised orthologous group 0.758190 flavodoxin - COG2052 Uncharacterized protein conserved in bacteria 0.757079 chlorophyll - COG3330 Uncharacterized protein conserved in bacteria 0.755475 chlorophyll - NOG13226 non supervised orthologous group 0.755475 chlorophyll - NOG10533 non supervised orthologous group 0.751391 photosynthesis - NOG09697 non supervised orthologous group 0.751391 photosynthesis - NOG14127 non supervised orthologous group 0.741613 photosystem - NOG10533 non supervised orthologous group 0.741613 photosystem - NOG13226 non supervised orthologous group 0.726849 flavodoxin - COG4242 Cyanophycinase and related exopeptidases 0.725593 photosynthesis - NOG13226 non supervised orthologous group 0.725593 photosynthesis - NOG10533 non supervised orthologous group 0.696452 flavodoxin - NOG09697 non supervised orthologous group 0.696452 flavodoxin - NOG14127 non supervised orthologous group 0.695584 variabilis - COG5322 Predicted dehydrogenase 0.689196 variabilis - COG4995 Uncharacterized protein conserved in bacteria 0.678351 variabilis - NOG09697 non supervised orthologous group 0.678351 variabilis - NOG14127 non supervised orthologous group 0.673368 chloroplast - COG5401 Spore germination protein 0.669988 flavodoxin - NOG10341 non supervised orthologous group 0.667910 variabilis - NOG09669 non supervised orthologous group 0.667910 variabilis - COG4370 Uncharacterized protein conserved in bacteria 0.666212 variabilis - COG3330 Uncharacterized protein conserved in bacteria 0.659479 flavodoxin - COG5322 Predicted dehydrogenase 0.655419 endospore - COG2385 Sporulation protein and related proteins 0.652305 thuringiensis - COG5401 Spore germination protein 0.651335 variabilis - COG4250 Predicted sensor protein/domain 0.650296 ferredoxins - COG2052 Uncharacterized protein conserved in bacteria 0.648056 variabilis - COG4242 Cyanophycinase and related exopeptidases 0.645024 endospore - COG5401 Spore germination protein 0.644233 flavodoxin - COG1453 Predicted oxidoreductases of the aldo/keto reductase family 0.643936 variabilis - NOG12317 non supervised orthologous group 0.643514 variabilis - NOG10341 non supervised orthologous group 0.640093 flavodoxin - NOG13226 non supervised orthologous group 0.640093 flavodoxin - NOG10533 non supervised orthologous group 0.639771 chloroplast - COG3330 Uncharacterized protein conserved in bacteria 0.634190 ferredoxin - COG2052 Uncharacterized protein conserved in bacteria 0.632709 flavodoxin - COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component 0.631976 chloroplast - NOG12317 non supervised orthologous group 0.630273 flavodoxin - COG4995 Uncharacterized protein conserved in bacteria 0.629424 ferredoxin - COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component 0.625424 endospore - COG3854 Uncharacterized protein conserved in bacteria 0.622416 ferredoxins - COG3937 Uncharacterized conserved protein 0.621260 biochemistry - COG2052 Uncharacterized protein conserved in bacteria 0.619732 ferredoxin - COG4242 Cyanophycinase and related exopeptidases 0.617568 chloroplast - COG2052 Uncharacterized protein conserved in bacteria 0.615746 spinach - COG3330 Uncharacterized protein conserved in bacteria 0.613775 glutamine - COG2052 Uncharacterized protein conserved in bacteria Cluster 8 ----------------------------------------------------------- 0.791393 xylanases - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.765387 glucanase - COG3507 Beta-xylosidase 0.751389 xylanases - COG3507 Beta-xylosidase 0.749683 xylanases - COG3860 Uncharacterized protein conserved in bacteria 0.748205 xylanase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.730662 xylanase - COG3507 Beta-xylosidase 0.725479 xylanases - NOG12385 Putative oxidoreductase 0.723556 xylanases - NOG08018 non supervised orthologous group 0.723224 endospore - COG4187 Arginine degradation protein (predicted deacylase) 0.722925 sporulation - NOG12385 Putative oxidoreductase 0.714805 endospore - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.701390 cellulase - COG3507 Beta-xylosidase 0.701108 xylanase - NOG12385 Putative oxidoreductase 0.700743 xylanases - COG3940 Predicted beta-xylosidase 0.699381 xylanases - COG3861 Uncharacterized protein conserved in bacteria 0.698839 sporulation - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.692393 amylase - COG3507 Beta-xylosidase 0.685545 subtilisin - COG3507 Beta-xylosidase 0.682201 xylanase - COG3860 Uncharacterized protein conserved in bacteria 0.678586 endospore - COG3507 Beta-xylosidase 0.676457 germination - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.674197 subtilisin - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.670275 sporulation - NOG08018 non supervised orthologous group 0.667153 cellulase - NOG12385 Putative oxidoreductase 0.665857 subtilisin - NOG12385 Putative oxidoreductase 0.665505 xylanase - NOG08018 non supervised orthologous group 0.662833 methyltransferases - COG3507 Beta-xylosidase 0.662263 endoglucanase - COG3507 Beta-xylosidase 0.658309 glycosyltransferase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.656849 xylanases - COG3866 Pectate lyase 0.654157 endospore - NOG12385 Putative oxidoreductase 0.653522 xylanases - NOG04140 non supervised orthologous group 0.648585 xylanase - COG3940 Predicted beta-xylosidase 0.646670 endoglucanase - COG2730 Endoglucanase 0.644944 xylanases - NOG09568 non supervised orthologous group 0.644322 xylanases - NOG04066 non supervised orthologous group 0.641117 germination - COG3940 Predicted beta-xylosidase 0.640868 germination - COG3507 Beta-xylosidase 0.639561 sporulation - COG3860 Uncharacterized protein conserved in bacteria 0.638847 germination - COG4187 Arginine degradation protein (predicted deacylase) 0.638599 endospore - COG4294 UV damage repair endonuclease 0.636902 xylanase - COG3861 Uncharacterized protein conserved in bacteria 0.633433 xylanase - COG3866 Pectate lyase 0.632677 glucanase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.630742 sporulation - COG4187 Arginine degradation protein (predicted deacylase) 0.630061 cellulase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.629805 endospore - COG3860 Uncharacterized protein conserved in bacteria 0.629187 sporulation - COG3507 Beta-xylosidase 0.627014 germination - NOG08018 non supervised orthologous group 0.618049 glucanase - COG2730 Endoglucanase 0.617653 xylanases - COG4247 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) 0.614924 barley - COG2730 Endoglucanase 0.614847 xylanases - COG4294 UV damage repair endonuclease 0.612788 xylanase - NOG04140 non supervised orthologous group Cluster 9 ----------------------------------------------------------- 0.784130 serotyping - COG3513 Uncharacterized protein conserved in bacteria 0.671199 serotyping - COG3512 Uncharacterized protein conserved in bacteria Cluster 10 ----------------------------------------------------------- 0.780255 actinomyces - NOG06584 non supervised orthologous group 0.734848 bacteroides - NOG06584 non supervised orthologous group 0.712766 bacteroides - NOG14535 non supervised orthologous group 0.711788 peptostreptococcus - NOG06584 non supervised orthologous group 0.707167 anaerobe - NOG06584 non supervised orthologous group 0.705908 peptostreptococcus - NOG14535 non supervised orthologous group 0.679403 anaerobe - NOG14535 non supervised orthologous group 0.665685 fragilis - NOG06584 non supervised orthologous group 0.656072 bacteroides - NOG14203 non supervised orthologous group 0.655424 actinomyces - COG3973 Superfamily I DNA and RNA helicases 0.631157 fragilis - NOG14203 non supervised orthologous group 0.619978 peptostreptococcus - NOG14203 non supervised orthologous group 0.617490 clindamycin - NOG14203 non supervised orthologous group Cluster 11 ----------------------------------------------------------- 0.774752 stenotrophomonas - COG3746 Phosphate-selective porin 0.748624 maltophilia - COG3746 Phosphate-selective porin 0.727782 stenotrophomonas - COG3667 Uncharacterized protein involved in copper resistance 0.686891 stenotrophomonas - NOG08477 non supervised orthologous group 0.682895 stenotrophomonas - COG4287 PhoPQ-activated pathogenicity-related protein 0.675378 maltophilia - NOG08477 non supervised orthologous group 0.667151 stenotrophomonas - COG4229 Predicted enolase-phosphatase 0.665163 maltophilia - COG3667 Uncharacterized protein involved in copper resistance 0.662066 stenotrophomonas - COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 0.660112 stenotrophomonas - COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain 0.646927 stenotrophomonas - COG2941 Ubiquinone biosynthesis protein COQ7 0.644691 stenotrophomonas - COG3659 Carbohydrate-selective porin 0.641093 exopolysaccharide - COG3746 Phosphate-selective porin 0.634315 acinetobacter - COG4726 Tfp pilus assembly protein PilX 0.628161 maltophilia - COG3659 Carbohydrate-selective porin 0.627949 stenotrophomonas - COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases 0.627208 acinetobacter - COG4966 Tfp pilus assembly protein PilW 0.620640 stenotrophomonas - NOG08482 non supervised orthologous group 0.619091 maltophilia - COG4229 Predicted enolase-phosphatase 0.614080 stenotrophomonas - NOG08527 non supervised orthologous group Cluster 12 ----------------------------------------------------------- 0.770556 proteasome - COG3462 Predicted membrane protein 0.762373 proteasome - COG3430 Uncharacterized protein conserved in archaea 0.762373 proteasome - COG3389 Uncharacterized protein conserved in archaea 0.750683 proteasome - COG3388 Uncharacterized protein conserved in archaea Cluster 13 ----------------------------------------------------------- 0.765745 opsonization - COG3942 Surface antigen 0.723709 fibronectin - COG3942 Surface antigen 0.711766 physician - COG3942 Surface antigen 0.705188 management - COG1636 Uncharacterized protein conserved in bacteria 0.700766 recurrence - COG1636 Uncharacterized protein conserved in bacteria 0.689384 institution - COG3942 Surface antigen 0.688291 empyema - COG3442 Predicted glutamine amidotransferase 0.676559 fibrinogen - COG3942 Surface antigen 0.670790 institution - COG1636 Uncharacterized protein conserved in bacteria 0.667576 childhood - COG1636 Uncharacterized protein conserved in bacteria 0.666634 drainage - COG3442 Predicted glutamine amidotransferase 0.664271 opsonization - COG4300 Predicted permease, cadmium resistance protein 0.662540 coagulation - COG4300 Predicted permease, cadmium resistance protein 0.659323 empyema - COG3942 Surface antigen 0.654822 outpatient - COG3942 Surface antigen 0.654155 aspiration - COG3442 Predicted glutamine amidotransferase 0.645275 empyema - COG4300 Predicted permease, cadmium resistance protein 0.645249 empyema - COG4720 Predicted membrane protein 0.644304 isolate - COG1636 Uncharacterized protein conserved in bacteria 0.642156 emergency - COG1636 Uncharacterized protein conserved in bacteria 0.637538 opsonization - COG4709 Predicted membrane protein 0.637388 drainage - COG3942 Surface antigen 0.637365 opsonization - NOG07968 non supervised orthologous group 0.637163 episode - COG3942 Surface antigen 0.637138 susceptibility - COG1636 Uncharacterized protein conserved in bacteria 0.637093 diabetes - COG3442 Predicted glutamine amidotransferase 0.636636 phagocytosis - COG4709 Predicted membrane protein 0.636448 coagulation - COG1636 Uncharacterized protein conserved in bacteria 0.630511 debridement - COG4720 Predicted membrane protein 0.625937 admission - COG1636 Uncharacterized protein conserved in bacteria 0.625535 debridement - COG3442 Predicted glutamine amidotransferase 0.625532 peritonitis - COG1636 Uncharacterized protein conserved in bacteria 0.622127 management - COG3942 Surface antigen 0.622123 drainage - COG4720 Predicted membrane protein 0.620626 abscess - COG3442 Predicted glutamine amidotransferase 0.617500 recurrence - COG3942 Surface antigen 0.617151 peritonitis - COG3942 Surface antigen 0.615779 effusion - COG3942 Surface antigen 0.614817 coagulation - COG3942 Surface antigen Cluster 14 ----------------------------------------------------------- 0.764199 pseudotuberculosis - COG4924 Uncharacterized protein conserved in bacteria 0.737912 pseudotuberculosis - COG4331 Predicted membrane protein 0.730738 rattus - COG4331 Predicted membrane protein 0.729377 pseudotuberculosis - COG4913 Uncharacterized protein conserved in bacteria 0.723828 rattus - NOG08582 non supervised orthologous group 0.692379 rattus - NOG09834 non supervised orthologous group 0.687545 biovars - COG3892 Uncharacterized protein conserved in bacteria 0.676978 biovars - COG4331 Predicted membrane protein 0.676453 biovars - COG3683 ABC-type uncharacterized transport system, periplasmic component 0.657839 rodent - NOG08582 non supervised orthologous group 0.641323 pseudotuberculosis - NOG08582 non supervised orthologous group 0.639245 rattus - NOG06493 non supervised orthologous group 0.633337 biovars - COG5373 Predicted membrane protein 0.631038 biovars - COG4963 Flp pilus assembly protein, ATPase CpaE Cluster 15 ----------------------------------------------------------- 0.764105 endospore - COG2359 Sporulation protein 0.743047 endospore - COG1728 Uncharacterized protein conserved in bacteria 0.736342 endospore - NOG14705 non supervised orthologous group 0.714851 sporulation - COG2359 Sporulation protein 0.682034 sporulation - COG1728 Uncharacterized protein conserved in bacteria 0.677632 endospore - COG4200 Uncharacterized protein conserved in bacteria 0.669094 endospore - COG3874 Uncharacterized conserved protein 0.666893 thermophile - COG1728 Uncharacterized protein conserved in bacteria 0.664958 stearothermophilus - COG1728 Uncharacterized protein conserved in bacteria 0.661089 sporulation - COG4200 Uncharacterized protein conserved in bacteria 0.658551 sporulation - NOG14705 non supervised orthologous group 0.653369 thuringiensis - COG1728 Uncharacterized protein conserved in bacteria 0.651693 thermophile - COG1582 Uncharacterized protein, possibly involved in motility 0.651674 thermophile - NOG14705 non supervised orthologous group 0.644677 germination - COG2359 Sporulation protein 0.639940 glucanase - COG1728 Uncharacterized protein conserved in bacteria 0.638614 stearothermophilus - NOG14705 non supervised orthologous group 0.636305 sporulation - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.635177 sporulation - COG3874 Uncharacterized conserved protein 0.633492 endospore - COG1582 Uncharacterized protein, possibly involved in motility 0.630757 thymine - COG1582 Uncharacterized protein, possibly involved in motility 0.623629 thuringiensis - NOG14705 non supervised orthologous group 0.619496 thermophile - COG4200 Uncharacterized protein conserved in bacteria 0.618885 thermostability - COG1586 S-adenosylmethionine decarboxylase 0.618144 glucanase - NOG14705 non supervised orthologous group 0.615637 catalysis - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.615330 xylanase - COG2359 Sporulation protein 0.614208 stearothermophilus - COG1582 Uncharacterized protein, possibly involved in motility Cluster 16 ----------------------------------------------------------- 0.755607 artery - COG4284 UDP-glucose pyrophosphorylase 0.741989 bypass - COG4284 UDP-glucose pyrophosphorylase 0.726633 aneurysm - COG4284 UDP-glucose pyrophosphorylase 0.723057 artery - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.705191 aneurysm - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.699289 fibrinogen - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.639072 aneurysm - COG2271 Sugar phosphate permease 0.630901 diabetes - COG1114 Branched-chain amino acid permeases 0.626281 prevention - COG2271 Sugar phosphate permease 0.625221 artery - COG2271 Sugar phosphate permease 0.623414 surgery - COG1114 Branched-chain amino acid permeases Cluster 17 ----------------------------------------------------------- 0.755410 viridans - COG3942 Surface antigen 0.754351 catarrhalis - COG4300 Predicted permease, cadmium resistance protein 0.744047 hinton - COG1636 Uncharacterized protein conserved in bacteria 0.737275 sanguis - COG3942 Surface antigen 0.718315 colonisation - COG1636 Uncharacterized protein conserved in bacteria 0.717764 mueller - COG1636 Uncharacterized protein conserved in bacteria 0.716396 sanguis - COG4300 Predicted permease, cadmium resistance protein 0.708826 tonsillitis - COG3942 Surface antigen 0.707719 branhamella - COG4300 Predicted permease, cadmium resistance protein 0.707713 pneumococcus - COG4300 Predicted permease, cadmium resistance protein 0.701511 carriage - COG1636 Uncharacterized protein conserved in bacteria 0.700061 carriage - COG4300 Predicted permease, cadmium resistance protein 0.688147 bacteraemia - COG1636 Uncharacterized protein conserved in bacteria 0.688057 cefaclor - COG4300 Predicted permease, cadmium resistance protein 0.680711 moraxella - COG4300 Predicted permease, cadmium resistance protein 0.676158 cellulitis - COG4300 Predicted permease, cadmium resistance protein 0.673916 glomerulonephritis - COG3942 Surface antigen 0.670904 viridans - COG4300 Predicted permease, cadmium resistance protein 0.669491 otitis - COG4300 Predicted permease, cadmium resistance protein 0.669094 prophylaxis - COG1636 Uncharacterized protein conserved in bacteria 0.665839 nasopharynx - COG4300 Predicted permease, cadmium resistance protein 0.665830 hypotension - COG3942 Surface antigen 0.649764 cefaclor - COG3942 Surface antigen 0.642042 prophylaxis - COG3942 Surface antigen 0.641146 cellulitis - COG3942 Surface antigen 0.640609 hypotension - COG4300 Predicted permease, cadmium resistance protein 0.630775 sinusitis - COG4300 Predicted permease, cadmium resistance protein 0.627634 viridans - NOG07968 non supervised orthologous group 0.619461 cellulitis - COG1636 Uncharacterized protein conserved in bacteria 0.616406 bacteraemia - COG4300 Predicted permease, cadmium resistance protein 0.613172 cellulitis - COG4720 Predicted membrane protein Cluster 18 ----------------------------------------------------------- 0.754245 nodule - COG3701 Type IV secretory pathway, TrbF components 0.742810 nodule - COG5394 Uncharacterized protein conserved in bacteria Cluster 19 ----------------------------------------------------------- 0.752138 stomach - COG2604 Uncharacterized protein conserved in bacteria 0.698985 cytotoxin - COG2604 Uncharacterized protein conserved in bacteria 0.652438 stomach - COG2121 Uncharacterized protein conserved in bacteria 0.637590 stomach - COG2143 Thioredoxin-related protein 0.625975 diarrhea - COG1969 Ni,Fe-hydrogenase I cytochrome b subunit 0.625155 metronidazole - COG2604 Uncharacterized protein conserved in bacteria 0.621149 diarrhea - COG0298 Hydrogenase maturation factor 0.619152 diarrhea - COG0374 Ni,Fe-hydrogenase I large subunit 0.615315 diarrhoea - COG0309 Hydrogenase maturation factor 0.612730 colitis - COG0298 Hydrogenase maturation factor Cluster 20 ----------------------------------------------------------- 0.750394 macrolides - NOG04835 non supervised orthologous group 0.691298 macrolide - NOG04835 non supervised orthologous group 0.656895 macrolides - COG2348 Uncharacterized protein involved in methicillin resistance 0.648205 macrolide - COG2503 Predicted secreted acid phosphatase 0.645351 macrolides - COG4485 Predicted membrane protein Cluster 21 ----------------------------------------------------------- 0.749717 hyperthermophiles - COG1856 Uncharacterized homolog of biotin synthetase 0.749717 hyperthermophiles - COG2516 Biotin synthase-related enzyme 0.705310 hyperthermophiles - COG1517 Uncharacterized protein predicted to be involved in DNA repair 0.698171 hyperthermophile - COG2245 Predicted membrane protein 0.698033 hyperthermophiles - COG1857 Uncharacterized protein predicted to be involved in DNA repair 0.697320 hyperthermophiles - COG1468 RecB family exonuclease 0.693165 hyperthermophiles - COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.692698 hyperthermophiles - COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase 0.692698 hyperthermophiles - COG4345 Uncharacterized protein conserved in archaea 0.691018 hyperthermophiles - COG2441 Predicted butyrate kinase 0.690692 hyperthermophile - COG1517 Uncharacterized protein predicted to be involved in DNA repair 0.673898 hyperthermophile - COG1906 Uncharacterized conserved protein 0.664250 hyperthermophile - COG1110 Reverse gyrase 0.664162 hyperthermophile - COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN 0.662533 hyperthermophiles - COG2112 Predicted Ser/Thr protein kinase 0.657906 hyperthermophiles - NOG07117 non supervised orthologous group 0.657221 hyperthermophiles - COG3889 Predicted solute binding protein 0.652792 hyperthermophile - COG2112 Predicted Ser/Thr protein kinase 0.648371 hyperthermophile - COG4047 Uncharacterized protein conserved in archaea 0.646058 hyperthermophile - COG1483 Predicted ATPase (AAA+ superfamily) 0.646058 hyperthermophile - COG1743 Adenine-specific DNA methylase containing a Zn-ribbon 0.644908 hyperthermophiles - COG1110 Reverse gyrase 0.641091 hyperthermophile - COG2411 Uncharacterized conserved protein 0.639330 hyperthermophile - COG1318 Predicted transcriptional regulators 0.638430 hyperthermophiles - COG2254 Predicted HD superfamily hydrolase, possibly a nuclease 0.638409 hyperthermophile - COG2413 Predicted nucleotidyltransferase 0.637668 hyperthermophiles - COG2522 Predicted transcriptional regulator 0.636973 hyperthermophiles - COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN 0.636143 hyperthermophile - COG2254 Predicted HD superfamily hydrolase, possibly a nuclease 0.632876 hyperthermophiles - COG2419 Uncharacterized conserved protein 0.631567 hyperthermophile - COG2419 Uncharacterized conserved protein 0.631082 hyperthermophile - COG3889 Predicted solute binding protein 0.627871 hyperthermophile - COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.626311 hyperthermophile - COG2516 Biotin synthase-related enzyme 0.626311 hyperthermophile - COG1856 Uncharacterized homolog of biotin synthetase 0.625300 hyperthermophiles - COG2413 Predicted nucleotidyltransferase 0.623408 archaeon - COG2522 Predicted transcriptional regulator 0.619811 hyperthermophile - COG2100 Predicted Fe-S oxidoreductase 0.613789 holliday - COG1856 Uncharacterized homolog of biotin synthetase 0.613789 holliday - COG2516 Biotin synthase-related enzyme 0.613666 hyperthermophile - COG1913 Predicted Zn-dependent proteases 0.612606 hyperthermophiles - COG1906 Uncharacterized conserved protein Cluster 22 ----------------------------------------------------------- 0.747610 glucosidase - COG2421 Predicted acetamidase/formamidase 0.705613 holliday - COG2421 Predicted acetamidase/formamidase 0.700262 hyperthermophiles - COG2421 Predicted acetamidase/formamidase 0.698964 hyperthermophile - COG2421 Predicted acetamidase/formamidase 0.659496 aminotransferase - COG2421 Predicted acetamidase/formamidase 0.643454 cellobiose - COG2421 Predicted acetamidase/formamidase 0.626180 polymerases - COG2421 Predicted acetamidase/formamidase 0.626064 thermophilus - COG2421 Predicted acetamidase/formamidase Cluster 23 ----------------------------------------------------------- 0.746693 alginate - COG4757 Predicted alpha/beta hydrolase 0.671982 biodegradation - COG4757 Predicted alpha/beta hydrolase 0.658372 toluene - COG4757 Predicted alpha/beta hydrolase 0.646619 alcaligenes - COG4757 Predicted alpha/beta hydrolase 0.625352 dioxygenase - COG4757 Predicted alpha/beta hydrolase Cluster 24 ----------------------------------------------------------- 0.742872 phosphoprotein - COG4748 Uncharacterized conserved protein Cluster 25 ----------------------------------------------------------- 0.738020 purpura - COG1636 Uncharacterized protein conserved in bacteria 0.726584 purpura - COG4300 Predicted permease, cadmium resistance protein Cluster 26 ----------------------------------------------------------- 0.737697 symbiont - COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) 0.677292 symbiont - COG1509 Lysine 2,3-aminomutase 0.636380 glucans - COG1509 Lysine 2,3-aminomutase 0.631123 seedling - COG3766 Predicted membrane protein 0.622604 tomato - COG3533 Uncharacterized protein conserved in bacteria Cluster 27 ----------------------------------------------------------- 0.737570 haemin - COG4393 Predicted membrane protein 0.731631 haemin - COG3657 Uncharacterized protein conserved in bacteria 0.701573 capsular - COG3657 Uncharacterized protein conserved in bacteria 0.676039 capsular - COG3636 Predicted transcriptional regulator 0.672891 haemin - COG3636 Predicted transcriptional regulator 0.670265 haemin - COG4331 Predicted membrane protein 0.655972 haemin - COG3350 Uncharacterized conserved protein 0.635986 haemin - NOG08582 non supervised orthologous group 0.634426 capsular - COG4393 Predicted membrane protein 0.632971 capsular - COG3514 Uncharacterized protein conserved in bacteria 0.627101 capsular - COG3683 ABC-type uncharacterized transport system, periplasmic component Cluster 28 ----------------------------------------------------------- 0.735936 catechol - COG4323 Predicted membrane protein 0.672689 catechol - COG3258 Cytochrome c 0.654682 toluene - COG4323 Predicted membrane protein 0.653326 catechol - NOG16120 non supervised orthologous group 0.646401 catechol - NOG29369 non supervised orthologous group 0.646373 catechol - COG4324 Predicted aminopeptidase 0.643099 catechol - COG4254 Uncharacterized protein conserved in bacteria 0.629074 catechol - COG3650 Predicted membrane protein 0.628848 catechol - NOG18807 non supervised orthologous group 0.628848 catechol - NOG09828 non supervised orthologous group Cluster 29 ----------------------------------------------------------- 0.733275 haemolyticus - COG4721 Predicted membrane protein 0.718885 catheter - COG4721 Predicted membrane protein 0.670326 cefazolin - COG4721 Predicted membrane protein 0.640177 oxacillin - COG4721 Predicted membrane protein 0.635937 vancomycin - COG4721 Predicted membrane protein 0.622017 coagulase - COG4721 Predicted membrane protein Cluster 30 ----------------------------------------------------------- 0.732770 gangrene - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.717017 gangrene - NOG09246 non supervised orthologous group 0.705294 gangrene - COG3404 Methenyl tetrahydrofolate cyclohydrolase 0.688539 gangrene - COG1243 Histone acetyltransferase 0.676275 gangrene - COG3862 Uncharacterized protein with conserved CXXC pairs 0.670852 gangrene - NOG28580 non supervised orthologous group 0.665104 gangrene - COG3968 Uncharacterized protein related to glutamine synthetase 0.660809 gangrene - NOG13102 non supervised orthologous group 0.649165 anaerobe - COG3877 Uncharacterized protein conserved in bacteria 0.646269 fragilis - NOG09246 non supervised orthologous group 0.644979 anaerobe - COG3862 Uncharacterized protein with conserved CXXC pairs 0.644855 bacteroides - NOG13102 non supervised orthologous group 0.640873 bacteroides - COG3877 Uncharacterized protein conserved in bacteria 0.632199 anaerobe - NOG28580 non supervised orthologous group 0.630762 fragilis - COG1243 Histone acetyltransferase 0.627175 peptostreptococcus - COG3877 Uncharacterized protein conserved in bacteria 0.626235 bacteroides - NOG28580 non supervised orthologous group 0.618156 bacteroides - COG3862 Uncharacterized protein with conserved CXXC pairs 0.615897 bacteroides - NOG09246 non supervised orthologous group Cluster 31 ----------------------------------------------------------- 0.732521 germination - COG3584 Uncharacterized protein conserved in bacteria 0.689480 germination - COG3426 Butyrate kinase 0.686460 endospore - COG3584 Uncharacterized protein conserved in bacteria 0.660571 germination - COG1811 Uncharacterized membrane protein, possible Na+ channel or pump 0.647179 germination - COG3872 Predicted metal-dependent enzyme 0.625225 cellobiose - COG3584 Uncharacterized protein conserved in bacteria 0.624935 cellobiose - COG3426 Butyrate kinase 0.622443 germination - COG1480 Predicted membrane-associated HD superfamily hydrolase 0.622045 xylose - COG3584 Uncharacterized protein conserved in bacteria 0.620288 starch - COG3584 Uncharacterized protein conserved in bacteria 0.613991 xylose - COG3426 Butyrate kinase Cluster 32 ----------------------------------------------------------- 0.727340 planta - COG5394 Uncharacterized protein conserved in bacteria 0.716925 symbiont - COG4227 Antirestriction protein 0.694614 symbiont - COG3701 Type IV secretory pathway, TrbF components 0.688363 planta - COG5267 Uncharacterized protein conserved in bacteria 0.688363 planta - COG4102 Uncharacterized protein conserved in bacteria 0.686479 rhizobium - COG5394 Uncharacterized protein conserved in bacteria 0.683359 symbiont - COG5394 Uncharacterized protein conserved in bacteria 0.670959 rhizobium - COG4553 Poly-beta-hydroxyalkanoate depolymerase (probably not required for symbiosis, but it has been proposed to be essential for the non-symbiotic state of Rhizobia (LARA L. MADISON AND GJALT W. HUISMAN, 1999) -> might thus be essential for re-infection... Moreover, a might turn off the PHA system for symbiosis, since it depolymerises the carbon storage molecule PHA 0.665448 rhizobium - COG3701 Type IV secretory pathway, TrbF components 0.655374 rhizobium - COG3838 Type IV secretory pathway, VirB2 components (pilins) 0.649336 planta - COG3828 Uncharacterized protein conserved in bacteria 0.622058 rhizobium - COG4102 Uncharacterized protein conserved in bacteria 0.622058 rhizobium - COG5267 Uncharacterized protein conserved in bacteria 0.614303 planta - COG4553 Poly-beta-hydroxyalkanoate depolymerase (probably not required for symbiosis, but it has been proposed to be essential for the non-symbiotic state of Rhizobia (LARA L. MADISON AND GJALT W. HUISMAN, 1999) -> might thus be essential for re-infection... Moreover, a might turn off the PHA system for symbiosis, since it depolymerises the carbon storage molecule PHA Cluster 33 ----------------------------------------------------------- 0.726623 intoxication - COG4413 Urea transporter Cluster 34 ----------------------------------------------------------- 0.725096 antitoxin - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.684143 toxigenic - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.657689 antitoxin - NOG14203 non supervised orthologous group 0.618205 intestine - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.613687 cholera - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily Cluster 35 ----------------------------------------------------------- 0.723254 thymine - COG1904 Glucuronate isomerase 0.668618 glucanase - COG1904 Glucuronate isomerase 0.653303 polyda - COG1904 Glucuronate isomerase 0.651300 stearothermophilus - COG1904 Glucuronate isomerase 0.649820 minicells - COG1904 Glucuronate isomerase 0.646893 endoglucanase - COG1904 Glucuronate isomerase 0.640597 minicells - COG2311 Predicted membrane protein 0.633242 megaterium - COG2311 Predicted membrane protein 0.630279 periplasm - COG1904 Glucuronate isomerase 0.626659 glucanase - COG2311 Predicted membrane protein 0.621602 endospore - COG1904 Glucuronate isomerase 0.619515 megaterium - COG1904 Glucuronate isomerase 0.619452 dichroism - COG1514 2-5 RNA ligase Cluster 36 ----------------------------------------------------------- 0.722498 glycosyltransferase - COG2364 Predicted membrane protein 0.705357 megaterium - COG2720 Uncharacterized vancomycin resistance protein 0.670737 xylanases - COG2364 Predicted membrane protein 0.669490 dehydratase - COG3973 Superfamily I DNA and RNA helicases 0.666594 arthrobacter - COG3973 Superfamily I DNA and RNA helicases 0.666472 xylanase - COG2364 Predicted membrane protein 0.663680 endospore - COG2364 Predicted membrane protein 0.662631 stearothermophilus - COG2720 Uncharacterized vancomycin resistance protein 0.659944 xylanase - COG3973 Superfamily I DNA and RNA helicases 0.638536 starch - COG2364 Predicted membrane protein 0.638375 xylanases - COG3973 Superfamily I DNA and RNA helicases 0.636013 biotransformation - COG3973 Superfamily I DNA and RNA helicases 0.634166 sporulation - COG2720 Uncharacterized vancomycin resistance protein 0.632910 endospore - COG2720 Uncharacterized vancomycin resistance protein 0.626150 starch - COG3973 Superfamily I DNA and RNA helicases Cluster 37 ----------------------------------------------------------- 0.718068 hamster - NOG14615 non supervised orthologous group 0.674914 hamster - COG1655 Uncharacterized protein conserved in bacteria Cluster 38 ----------------------------------------------------------- 0.715739 poisoning - COG1922 Teichoic acid biosynthesis proteins 0.673849 poisoning - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.643729 poisoning - COG1434 Uncharacterized conserved protein 0.631610 enterocolitis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Cluster 39 ----------------------------------------------------------- 0.715482 rhamnose - COG4443 Uncharacterized protein conserved in bacteria 0.673010 rhamnose - COG4687 Uncharacterized protein conserved in bacteria 0.663254 rhamnose - COG3579 Aminopeptidase C 0.652661 rhamnose - COG4708 Predicted membrane protein 0.642243 rhamnose - NOG09371 non supervised orthologous group 0.621379 rhamnose - COG3538 uncharacterized, freuqently in operons with sugar/polysaccharide-related proteins [rhamnose could be promising, in cell wall of some Gram- and Gram+ bacteria] (prev. Uncharacterized conserved protein) Cluster 40 ----------------------------------------------------------- 0.715262 implant - COG4492 ACT domain-containing protein 0.648123 silicone - COG4492 ACT domain-containing protein 0.636524 implant - COG3949 Uncharacterized membrane protein 0.618523 ointment - COG3949 Uncharacterized membrane protein 0.617164 implant - NOG08620 non supervised orthologous group 0.616679 device - COG3949 Uncharacterized membrane protein Cluster 41 ----------------------------------------------------------- 0.714146 gerbil - COG4393 Predicted membrane protein 0.697838 gerbil - COG4331 Predicted membrane protein 0.696621 gerbil - COG4268 McrBC 5-methylcytosine restriction system component 0.687429 gerbil - COG3350 Uncharacterized conserved protein 0.667650 gerbil - NOG08582 non supervised orthologous group 0.635520 gerbil - COG4099 Predicted peptidase 0.622237 gerbil - COG3867 Arabinogalactan endo-1,4-beta-galactosidase Cluster 42 ----------------------------------------------------------- 0.713492 actinomyces - NOG27896 non supervised orthologous group 0.702260 actinomyces - COG3864 Uncharacterized protein conserved in bacteria 0.678665 actinomyces - NOG10337 non supervised orthologous group 0.637884 actinomyces - NOG09952 non supervised orthologous group 0.630020 actinomyces - NOG08919 non supervised orthologous group Cluster 43 ----------------------------------------------------------- 0.713295 vancomycin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.679835 imipenem - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.618675 enterobacter - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.617539 proteus - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.615635 oxacillin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 44 ----------------------------------------------------------- 0.713063 vegetable - COG4748 Uncharacterized conserved protein 0.688981 starter - COG4748 Uncharacterized conserved protein 0.677338 cheese - COG4748 Uncharacterized conserved protein 0.672003 monocytogene - COG4912 Predicted DNA alkylation repair enzyme 0.666443 betaine - COG4748 Uncharacterized conserved protein 0.654639 bacteriocins - COG4748 Uncharacterized conserved protein 0.652316 bacteriocins - COG4912 Predicted DNA alkylation repair enzyme 0.644407 sausage - COG4748 Uncharacterized conserved protein 0.642992 vacuum - COG4748 Uncharacterized conserved protein 0.639121 bacteriocins - COG4767 Glycopeptide antibiotics resistance protein 0.632472 serovars - COG4748 Uncharacterized conserved protein 0.630344 cheese - COG4912 Predicted DNA alkylation repair enzyme 0.617331 bacteriocins - COG2848 Uncharacterized conserved protein Cluster 45 ----------------------------------------------------------- 0.711399 multilocus - COG3567 Uncharacterized protein conserved in bacteria 0.711399 multilocus - COG3566 Uncharacterized protein conserved in bacteria 0.629128 memory - COG3567 Uncharacterized protein conserved in bacteria 0.629128 memory - COG3566 Uncharacterized protein conserved in bacteria Cluster 46 ----------------------------------------------------------- 0.709809 enterobacter - COG4757 Predicted alpha/beta hydrolase 0.704855 maltophilia - COG4290 Guanyl-specific ribonuclease Sa 0.674233 maltophilia - COG4757 Predicted alpha/beta hydrolase 0.663037 maltophilia - NOG05512 non supervised orthologous group 0.660582 piperacillin - COG4757 Predicted alpha/beta hydrolase 0.653705 bacteriuria - COG4757 Predicted alpha/beta hydrolase 0.652375 exotoxin - COG4757 Predicted alpha/beta hydrolase 0.631582 ceftazidime - COG4757 Predicted alpha/beta hydrolase 0.624710 biofilms - COG4757 Predicted alpha/beta hydrolase 0.623158 proteus - COG4757 Predicted alpha/beta hydrolase 0.619865 pyelonephritis - COG4757 Predicted alpha/beta hydrolase 0.616073 acinetobacter - COG4757 Predicted alpha/beta hydrolase 0.615922 stenotrophomonas - NOG05512 non supervised orthologous group 0.613027 stenotrophomonas - COG4290 Guanyl-specific ribonuclease Sa Cluster 47 ----------------------------------------------------------- 0.709514 multilocus - COG3759 Predicted membrane protein Cluster 48 ----------------------------------------------------------- 0.705840 lecithinase - COG3878 Uncharacterized protein conserved in bacteria 0.699507 lecithinase - COG2738 Predicted Zn-dependent protease 0.695397 lecithinase - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.662403 lecithinase - COG1774 Uncharacterized homolog of PSP1 0.651415 sausage - COG3878 Uncharacterized protein conserved in bacteria 0.649443 lecithinase - COG3870 Uncharacterized protein conserved in bacteria 0.634048 lecithinase - COG2340 Uncharacterized protein with SCP/PR1 domains Cluster 49 ----------------------------------------------------------- 0.704188 phospholipid - COG1910 Periplasmic molybdate-binding protein/domain 0.640056 phospholipid - COG1416 Uncharacterized conserved protein Cluster 50 ----------------------------------------------------------- 0.701118 haemin - COG4929 Uncharacterized membrane-anchored protein 0.650386 trimethoprim - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase 0.634237 haemin - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport Cluster 51 ----------------------------------------------------------- 0.700978 serotyping - COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism 0.627462 serotypes - COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Cluster 52 ----------------------------------------------------------- 0.700558 healing - NOG06005 non supervised orthologous group 0.682259 silicone - NOG06005 non supervised orthologous group 0.663579 healing - COG3886 Predicted HKD family nuclease Cluster 53 ----------------------------------------------------------- 0.700105 archaea - COG1865 Uncharacterized conserved protein 0.698335 thermostability - COG1865 Uncharacterized conserved protein 0.688128 archaeon - COG1361 S-layer domain 0.675950 diffraction - COG1865 Uncharacterized conserved protein 0.672242 archaea - COG1361 S-layer domain 0.669554 crystallization - COG1865 Uncharacterized conserved protein 0.662046 hyperthermophiles - COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 0.655357 archaebacterium - COG3374 Predicted membrane protein 0.654629 archaeon - COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 0.652815 archaeon - COG2512 Uncharacterized membrane-associated protein/domain 0.648090 hyperthermophiles - COG3371 Predicted membrane protein 0.645769 archaebacterium - COG3370 Uncharacterized protein conserved in archaea 0.643815 archaebacteria - COG3413 Predicted DNA binding protein 0.642536 archaeon - COG2237 Predicted membrane protein 0.637698 ferredoxin - COG1449 Alpha-amylase/alpha-mannosidase 0.634165 archaeon - COG1865 Uncharacterized conserved protein 0.627871 archaea - COG2237 Predicted membrane protein 0.626349 archaebacterium - COG3413 Predicted DNA binding protein 0.626341 archaeon - COG2412 Uncharacterized conserved protein 0.624537 archaebacteria - COG1865 Uncharacterized conserved protein 0.622327 archaebacteria - COG3370 Uncharacterized protein conserved in archaea 0.621726 acidocaldarius - COG3374 Predicted membrane protein 0.619817 archaebacterium - COG3432 Predicted transcriptional regulator 0.619745 archaeon - COG2874 Predicted ATPases involved in biogenesis of archaeal flagella 0.619745 archaeon - COG1955 Archaeal flagella assembly protein J 0.619745 archaeon - COG1681 Archaeal flagellins 0.618446 archaebacteria - COG3374 Predicted membrane protein 0.617975 hyperthermophiles - COG1361 S-layer domain 0.616560 acidocaldarius - COG3370 Uncharacterized protein conserved in archaea 0.615108 archaea - COG2412 Uncharacterized conserved protein 0.615051 archaea - COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 0.613745 archaea - COG2512 Uncharacterized membrane-associated protein/domain 0.612727 archaeon - COG1709 Predicted transcriptional regulator 0.612669 archaeon - COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) Cluster 54 ----------------------------------------------------------- 0.698883 lactam - COG2851 H+/citrate symporter 0.657612 lactamase - COG2851 H+/citrate symporter Cluster 55 ----------------------------------------------------------- 0.698103 implantation - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.693581 prosthesis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.689592 implant - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.686141 silicone - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.636345 chlorhexidine - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.613358 piperacillin - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Cluster 56 ----------------------------------------------------------- 0.697234 enterocolitis - COG4492 ACT domain-containing protein 0.667233 poisoning - COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 0.653543 poisoning - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.646133 poisoning - COG4492 ACT domain-containing protein 0.645167 poisoning - COG2738 Predicted Zn-dependent protease Cluster 57 ----------------------------------------------------------- 0.696111 lincomycin - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components 0.649952 tylosin - COG1176 ABC-type spermidine/putrescine transport system, permease component I 0.647517 lincomycin - COG1264 Phosphotransferase system IIB components 0.639436 tylosin - COG1177 ABC-type spermidine/putrescine transport system, permease component II 0.628794 lincomycin - COG2190 Phosphotransferase system IIA components 0.623323 tylosin - COG1264 Phosphotransferase system IIB components 0.620411 tylosin - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components 0.619030 tylosin - COG0687 Spermidine/putrescine-binding periplasmic protein 0.614474 peptostreptococcus - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components Cluster 58 ----------------------------------------------------------- 0.695087 metronidazole - COG5015 Uncharacterized conserved protein Cluster 59 ----------------------------------------------------------- 0.694926 glutamine - COG0464 ATPases of the AAA+ class 0.685561 subunit - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.680873 carbon - COG0464 ATPases of the AAA+ class 0.668795 acceptor - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.633317 crystallization - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.628714 dehydrogenase - COG0464 ATPases of the AAA+ class 0.614089 crystal - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cluster 60 ----------------------------------------------------------- 0.693662 succinate - COG1280 Putative threonine efflux protein 0.649501 coenzyme - COG1280 Putative threonine efflux protein 0.636370 starvation - COG4147 Predicted symporter 0.626859 glutamine - COG2059 Chromate transport protein ChrA 0.624607 valine - COG2066 Glutaminase 0.617777 succinate - COG2059 Chromate transport protein ChrA Cluster 61 ----------------------------------------------------------- 0.690726 cytomegalovirus - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 0.684034 seropositivity - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 0.667871 serology - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 0.619011 seroprevalence - COG1664 Integral membrane protein CcmA involved in cell shape determination 0.613906 seropositivity - COG1664 Integral membrane protein CcmA involved in cell shape determination Cluster 62 ----------------------------------------------------------- 0.689823 lactamases - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.672117 coccus - COG2610 H+/gluconate symporter and related permeases 0.667965 fragilis - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.640737 lactamase - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 63 ----------------------------------------------------------- 0.688006 implantation - COG4284 UDP-glucose pyrophosphorylase Cluster 64 ----------------------------------------------------------- 0.687501 purpura - COG3512 Uncharacterized protein conserved in bacteria 0.677781 polysaccharide - COG3512 Uncharacterized protein conserved in bacteria 0.667103 multilocus - COG3513 Uncharacterized protein conserved in bacteria 0.663079 purpura - COG3475 LPS biosynthesis protein 0.625925 fatality - COG3512 Uncharacterized protein conserved in bacteria Cluster 65 ----------------------------------------------------------- 0.686826 serotyping - COG2855 Predicted membrane protein 0.630498 serotyping - COG2932 Predicted transcriptional regulator Cluster 66 ----------------------------------------------------------- 0.685775 clindamycin - COG2035 Predicted membrane protein 0.622727 clindamycin - COG1621 Beta-fructosidases (levanase/invertase) Cluster 67 ----------------------------------------------------------- 0.685462 planta - COG5255 Uncharacterized protein conserved in bacteria 0.683019 tobacco - COG4711 Predicted membrane protein 0.649299 tobacco - COG5343 Uncharacterized protein conserved in bacteria 0.631920 planta - COG5343 Uncharacterized protein conserved in bacteria 0.621199 planta - COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain 0.621198 planta - COG3569 Topoisomerase IB 0.618083 tobacco - COG0467 RecA-superfamily ATPases implicated in signal transduction 0.617508 tobacco - NOG04033 non supervised orthologous group 0.617228 tobacco - COG5255 Uncharacterized protein conserved in bacteria 0.615464 tobacco - COG5278 Predicted periplasmic ligand-binding sensor domain Cluster 68 ----------------------------------------------------------- 0.682889 transl - COG1278 Cold shock proteins 0.666526 transl - COG1841 Ribosomal protein L30/L7E 0.618197 transl - COG4974 Site-specific recombinase XerD Cluster 69 ----------------------------------------------------------- 0.682042 avirulence - COG4099 Predicted peptidase 0.625902 avirulence - NOG05832 non supervised orthologous group Cluster 70 ----------------------------------------------------------- 0.681377 subunit - COG0530 Ca2+/Na+ antiporter 0.645887 atpase - COG0530 Ca2+/Na+ antiporter Cluster 71 ----------------------------------------------------------- 0.679990 counterimmunoelectrophoresis - COG3475 LPS biosynthesis protein 0.637002 pneumococcus - COG3475 LPS biosynthesis protein Cluster 72 ----------------------------------------------------------- 0.678489 lipopolysaccharides - COG4105 DNA uptake lipoprotein 0.646021 lipopolysaccharide - COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase 0.646021 lipopolysaccharide - COG1519 3-deoxy-D-manno-octulosonic-acid transferase 0.646021 lipopolysaccharide - COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase 0.644819 lipopolysaccharide - COG1663 Tetraacyldisaccharide-1-P 4-kinase 0.629351 lipopolysaccharides - COG1452 Organic solvent tolerance protein OstA 0.625804 lipopolysaccharides - COG1629 Outer membrane receptor proteins, mostly Fe transport 0.618366 lipopolysaccharides - COG1663 Tetraacyldisaccharide-1-P 4-kinase 0.617446 lipopolysaccharides - COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase 0.617446 lipopolysaccharides - COG1519 3-deoxy-D-manno-octulosonic-acid transferase 0.617446 lipopolysaccharides - COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase 0.617282 lipopolysaccharide - COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains 0.616824 lipopolysaccharides - COG2908 Uncharacterized protein conserved in bacteria Cluster 73 ----------------------------------------------------------- 0.677457 gonococcus - COG3219 Uncharacterized protein conserved in bacteria 0.674477 counterimmunoelectrophoresis - COG4797 Predicted regulatory domain of a methyltransferase 0.671772 gonococcus - COG4797 Predicted regulatory domain of a methyltransferase 0.654410 capsule - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.637481 nasopharynx - COG3219 Uncharacterized protein conserved in bacteria 0.635141 gonorrhoeae - COG3219 Uncharacterized protein conserved in bacteria 0.633477 capsule - COG3778 Uncharacterized protein conserved in bacteria 0.630829 gonococcus - COG3767 Uncharacterized low-complexity protein 0.624693 gonococcus - COG5266 ABC-type Co2+ transport system, periplasmic component 0.620755 capsular - COG3778 Uncharacterized protein conserved in bacteria 0.620431 gonorrhoeae - COG4797 Predicted regulatory domain of a methyltransferase 0.618469 nasopharynx - COG4797 Predicted regulatory domain of a methyltransferase Cluster 74 ----------------------------------------------------------- 0.677259 peptostreptococcus - COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes 0.631384 bacteroides - COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes Cluster 75 ----------------------------------------------------------- 0.677091 seedling - COG3910 Predicted ATPase Cluster 76 ----------------------------------------------------------- 0.675906 nitrogenase - COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain Cluster 77 ----------------------------------------------------------- 0.674879 biovars - COG3459 Cellobiose phosphorylase 0.620298 multiplication - COG3459 Cellobiose phosphorylase Cluster 78 ----------------------------------------------------------- 0.673853 institution - COG4732 Predicted membrane protein 0.622113 debridement - COG4732 Predicted membrane protein 0.618792 ciprofloxacin - COG3002 Uncharacterized protein conserved in bacteria 0.615975 drainage - COG4732 Predicted membrane protein 0.615301 surgery - COG4732 Predicted membrane protein 0.613689 peritonitis - COG4732 Predicted membrane protein Cluster 79 ----------------------------------------------------------- 0.673300 multilocus - COG3658 Cytochrome b Cluster 80 ----------------------------------------------------------- 0.672942 exopolysaccharide - COG5394 Uncharacterized protein conserved in bacteria 0.662449 exopolysaccharide - COG4798 Predicted methyltransferase 0.651510 exopolysaccharide - COG4102 Uncharacterized protein conserved in bacteria 0.651510 exopolysaccharide - COG5267 Uncharacterized protein conserved in bacteria 0.635627 exopolysaccharide - NOG08575 non supervised orthologous group 0.626260 exopolysaccharide - COG3652 Predicted outer membrane protein 0.624919 exopolysaccharide - COG4313 Protein involved in meta-pathway of phenol degradation Cluster 81 ----------------------------------------------------------- 0.672629 purpura - COG2932 Predicted transcriptional regulator 0.634307 polysaccharide - COG2932 Predicted transcriptional regulator 0.626914 tetanus - COG2932 Predicted transcriptional regulator Cluster 82 ----------------------------------------------------------- 0.671243 mammal - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.636959 intoxication - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.631290 enterocolitica - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport Cluster 83 ----------------------------------------------------------- 0.670926 rattus - COG1704 Uncharacterized conserved protein Cluster 84 ----------------------------------------------------------- 0.670164 pneumococcus - COG2932 Predicted transcriptional regulator 0.660857 opsonin - COG2932 Predicted transcriptional regulator 0.642706 carriage - COG2855 Predicted membrane protein 0.641808 branhamella - COG2932 Predicted transcriptional regulator 0.637140 catarrhalis - COG2932 Predicted transcriptional regulator 0.630810 septicaemia - COG2855 Predicted membrane protein 0.630296 opsonin - COG2855 Predicted membrane protein 0.621009 counterimmunoelectrophoresis - COG2932 Predicted transcriptional regulator 0.616780 cefotaxime - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.614512 nasopharynx - COG2932 Predicted transcriptional regulator 0.613373 septicaemia - COG4108 Peptide chain release factor RF-3 Cluster 85 ----------------------------------------------------------- 0.669676 stomach - COG1749 Flagellar hook protein FlgE 0.639594 stomach - COG1706 Flagellar basal-body P-ring protein 0.626724 stomach - COG1261 Flagellar basal body P-ring biosynthesis protein 0.626724 stomach - COG2063 Flagellar basal body L-ring protein Cluster 86 ----------------------------------------------------------- 0.666734 tobacco - NOG07139 non supervised orthologous group 0.623655 planta - NOG07139 non supervised orthologous group Cluster 87 ----------------------------------------------------------- 0.665984 osteomyelitis - COG3942 Surface antigen 0.631489 endocarditis - COG3942 Surface antigen Cluster 88 ----------------------------------------------------------- 0.665098 glycosyltransferase - NOG07232 non supervised orthologous group 0.663995 formate - COG4978 Transcriptional regulator, effector-binding domain/component 0.654190 coenzyme - COG4978 Transcriptional regulator, effector-binding domain/component 0.626794 glutamine - COG4978 Transcriptional regulator, effector-binding domain/component 0.620047 stoichiometry - COG4978 Transcriptional regulator, effector-binding domain/component Cluster 89 ----------------------------------------------------------- 0.662754 leukocytes - COG4413 Urea transporter 0.654441 abscess - COG4413 Urea transporter 0.649511 ciprofloxacin - COG4413 Urea transporter 0.630278 suspicion - COG4413 Urea transporter 0.621983 epidemic - COG4536 Putative Mg2+ and Co2+ transporter CorB 0.621087 ofloxacin - COG4413 Urea transporter Cluster 90 ----------------------------------------------------------- 0.662652 seedling - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component Cluster 91 ----------------------------------------------------------- 0.662557 bacteriocins - COG1434 Uncharacterized conserved protein 0.657575 carcass - COG1922 Teichoic acid biosynthesis proteins 0.643297 starter - COG3104 Dipeptide/tripeptide permease 0.630523 coliforms - COG1434 Uncharacterized conserved protein 0.626512 lecithinase - COG1434 Uncharacterized conserved protein 0.625879 spoilage - COG1434 Uncharacterized conserved protein 0.620207 sausage - COG3104 Dipeptide/tripeptide permease 0.616856 starter - COG1434 Uncharacterized conserved protein Cluster 92 ----------------------------------------------------------- 0.661117 serology - NOG08579 non supervised orthologous group Cluster 93 ----------------------------------------------------------- 0.660460 haemolysin - NOG26252 non supervised orthologous group Cluster 94 ----------------------------------------------------------- 0.659901 phosphoprotein - COG4091 Predicted homoserine dehydrogenase Cluster 95 ----------------------------------------------------------- 0.658647 serogroup - COG1652 Uncharacterized protein containing LysM domain 0.640528 serogroups - COG1652 Uncharacterized protein containing LysM domain 0.628031 heptose - COG1652 Uncharacterized protein containing LysM domain 0.617057 serogroup - COG3658 Cytochrome b Cluster 96 ----------------------------------------------------------- 0.657399 toluene - COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains 0.620544 toluene - COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis. Cluster 97 ----------------------------------------------------------- 0.656586 cereus - COG2340 Uncharacterized protein with SCP/PR1 domains 0.650120 cereus - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.625145 cereus - COG3870 Uncharacterized protein conserved in bacteria 0.620724 cereus - COG2738 Predicted Zn-dependent protease Cluster 98 ----------------------------------------------------------- 0.656584 infection - COG0782 Transcription elongation factor 0.654856 emergency - COG0749 DNA polymerase I - 3-5 exonuclease and polymerase domains 0.642283 pathogen - COG0782 Transcription elongation factor 0.641416 country - COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) 0.629228 country - COG1862 Preprotein translocase subunit YajC 0.623741 health - COG1862 Preprotein translocase subunit YajC 0.614531 prevention - COG1862 Preprotein translocase subunit YajC 0.612696 person - COG1862 Preprotein translocase subunit YajC Cluster 99 ----------------------------------------------------------- 0.655415 vegetable - COG4091 Predicted homoserine dehydrogenase 0.653367 monocytogene - NOG20091 non supervised orthologous group 0.622229 starter - COG4932 Predicted outer membrane protein 0.622035 phospholipase - COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain 0.621031 bacteriocin - COG3962 Acetolactate synthase 0.618063 vacuum - COG4091 Predicted homoserine dehydrogenase 0.617549 bacteriocin - COG3718 Uncharacterized enzyme involved in inositol metabolism Cluster 100 ----------------------------------------------------------- 0.654647 chlorhexidine - COG1514 2-5 RNA ligase 0.651162 enterobacter - COG1514 2-5 RNA ligase 0.642740 device - COG1514 2-5 RNA ligase 0.627903 bacteriuria - COG0427 Acetyl-CoA hydrolase 0.618893 bacteriuria - COG1514 2-5 RNA ligase 0.618558 ointment - COG1514 2-5 RNA ligase Cluster 101 ----------------------------------------------------------- 0.654406 germination - COG1001 Adenine deaminase Cluster 102 ----------------------------------------------------------- 0.653925 sanguis - COG4475 Uncharacterized protein conserved in bacteria 0.641820 sanguis - COG3981 Predicted acetyltransferase 0.629087 sanguis - COG2035 Predicted membrane protein 0.622644 tonsillitis - COG2035 Predicted membrane protein Cluster 103 ----------------------------------------------------------- 0.653629 fixation - COG4095 Uncharacterized conserved protein Cluster 104 ----------------------------------------------------------- 0.652179 anaerobe - COG3875 Uncharacterized conserved protein 0.646496 anaerobe - COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Cluster 105 ----------------------------------------------------------- 0.651428 coccus - COG2348 Uncharacterized protein involved in methicillin resistance Cluster 106 ----------------------------------------------------------- 0.650928 toxigenic - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.639972 antitoxin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.625376 enterotoxin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 107 ----------------------------------------------------------- 0.650240 tetramer - COG1051 ADP-ribose pyrophosphatase 0.638081 catalysis - COG1051 ADP-ribose pyrophosphatase 0.616126 represser - COG2771 DNA-binding HTH domain-containing proteins Cluster 108 ----------------------------------------------------------- 0.649856 diarrhea - COG3681 Uncharacterized conserved protein 0.639095 colitis - NOG04347 non supervised orthologous group 0.637330 diarrhea - NOG04347 non supervised orthologous group 0.629379 enterotoxin - COG3314 Uncharacterized protein conserved in bacteria 0.626910 diarrhoea - NOG04347 non supervised orthologous group 0.620721 colitis - COG3681 Uncharacterized conserved protein Cluster 109 ----------------------------------------------------------- 0.648708 phospholipase - COG0232 dGTP triphosphohydrolase Cluster 110 ----------------------------------------------------------- 0.648538 maltophilia - COG4913 Uncharacterized protein conserved in bacteria Cluster 111 ----------------------------------------------------------- 0.648191 avirulence - COG5255 Uncharacterized protein conserved in bacteria 0.631982 avirulence - COG3754 Lipopolysaccharide biosynthesis protein Cluster 112 ----------------------------------------------------------- 0.647386 conjunctivitis - COG1925 Phosphotransferase system, HPr-related proteins Cluster 113 ----------------------------------------------------------- 0.647033 surgery - COG2035 Predicted membrane protein 0.618081 debridement - COG2035 Predicted membrane protein Cluster 114 ----------------------------------------------------------- 0.646732 nitrogenase - COG3411 Ferredoxin 0.635837 starvation - COG1512 Beta-propeller domains of methanol dehydrogenase type 0.622219 starvation - COG4783 Putative Zn-dependent protease, contains TPR repeats Cluster 115 ----------------------------------------------------------- 0.646416 microflora - NOG06584 non supervised orthologous group 0.632449 fermentation - COG3973 Superfamily I DNA and RNA helicases 0.623396 microflora - NOG14535 non supervised orthologous group 0.614959 epsilon - COG3973 Superfamily I DNA and RNA helicases Cluster 116 ----------------------------------------------------------- 0.645855 aminoglycoside - COG4413 Urea transporter Cluster 117 ----------------------------------------------------------- 0.645642 citrate - COG1226 Kef-type K+ transport systems, predicted NAD-binding component Cluster 118 ----------------------------------------------------------- 0.643614 lipooligosaccharides - COG3514 Uncharacterized protein conserved in bacteria Cluster 119 ----------------------------------------------------------- 0.643437 rifampicin - COG4974 Site-specific recombinase XerD 0.640543 outbreak - COG4974 Site-specific recombinase XerD Cluster 120 ----------------------------------------------------------- 0.643312 faecalis - COG3764 Sortase (surface protein transpeptidase) Cluster 121 ----------------------------------------------------------- 0.642821 succinate - COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains 0.626572 succinate - NOG28953 non supervised orthologous group Cluster 122 ----------------------------------------------------------- 0.642597 oligosaccharide - COG3779 Uncharacterized protein conserved in bacteria Cluster 123 ----------------------------------------------------------- 0.641625 fragilis - COG4492 ACT domain-containing protein Cluster 124 ----------------------------------------------------------- 0.641564 serodiagnosis - COG1659 Uncharacterized protein, linocin/CFP29 homolog 0.626726 histocompatibility - COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes 0.616176 granuloma - NOG08314 non supervised orthologous group Cluster 125 ----------------------------------------------------------- 0.641528 hydroxylation - COG3655 Predicted transcriptional regulator 0.636074 arthrobacter - COG3655 Predicted transcriptional regulator Cluster 126 ----------------------------------------------------------- 0.640968 serotyping - COG4283 Uncharacterized conserved protein Cluster 127 ----------------------------------------------------------- 0.640735 enterobacter - COG0386 Glutathione peroxidase Cluster 128 ----------------------------------------------------------- 0.639569 disinfectant - COG5405 ATP-dependent protease HslVU (ClpYQ), peptidase subunit 0.639569 disinfectant - COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit Cluster 129 ----------------------------------------------------------- 0.639238 chromophore - COG2066 Glutaminase 0.636418 ornithine - COG1129 ABC-type sugar transport system, ATPase component Cluster 130 ----------------------------------------------------------- 0.639167 enterotoxin - COG1528 Ferritin-like protein 0.624849 enterocolitis - COG1528 Ferritin-like protein 0.624187 toxigenic - COG1528 Ferritin-like protein 0.621832 metronidazole - COG1528 Ferritin-like protein Cluster 131 ----------------------------------------------------------- 0.638943 replicon - COG3485 Protocatechuate 3,4-dioxygenase beta subunit Cluster 132 ----------------------------------------------------------- 0.638686 dephosphorylation - COG0501 Zn-dependent protease with chaperone function 0.634433 mutagenesis - COG0501 Zn-dependent protease with chaperone function Cluster 133 ----------------------------------------------------------- 0.638615 starter - COG1930 ABC-type cobalt transport system, periplasmic component Cluster 134 ----------------------------------------------------------- 0.638173 actinomyces - COG3861 Uncharacterized protein conserved in bacteria Cluster 135 ----------------------------------------------------------- 0.637332 sludge - COG1524 putative pyrophosphatase (Uncharacterized proteins of the AP superfamily) Cluster 136 ----------------------------------------------------------- 0.637070 counterimmunoelectrophoresis - COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes 0.630468 counterimmunoelectrophoresis - NOG09685 non supervised orthologous group 0.623007 counterimmunoelectrophoresis - NOG18016 non supervised orthologous group Cluster 137 ----------------------------------------------------------- 0.636571 taxonomy - COG4320 Uncharacterized protein conserved in bacteria 0.621341 taxonomy - NOG09952 non supervised orthologous group Cluster 138 ----------------------------------------------------------- 0.636477 glomerulonephritis - NOG09279 non supervised orthologous group 0.633606 pharyngitis - COG2984 ABC-type uncharacterized transport system, periplasmic component 0.625542 pneumococcus - COG1322 Uncharacterized protein conserved in bacteria 0.623064 glomerulonephritis - COG1101 ABC-type uncharacterized transport system, ATPase component 0.617653 tonsillitis - COG1101 ABC-type uncharacterized transport system, ATPase component 0.616887 pharyngitis - COG1101 ABC-type uncharacterized transport system, ATPase component Cluster 139 ----------------------------------------------------------- 0.636394 germination - COG3773 Cell wall hydrolyses involved in spore germination 0.633457 endospore - COG3773 Cell wall hydrolyses involved in spore germination 0.621441 glucanase - COG3858 Predicted glycosyl hydrolase 0.619741 thuringiensis - COG3773 Cell wall hydrolyses involved in spore germination Cluster 140 ----------------------------------------------------------- 0.635455 polyketide - COG4247 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) Cluster 141 ----------------------------------------------------------- 0.633848 glutamine - COG3339 Uncharacterized conserved protein 0.620449 hydrogenase - COG1669 Predicted nucleotidyltransferases 0.616042 nitrogen - COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains 0.616042 nitrogen - COG1348 Nitrogenase subunit NifH (ATPase) Cluster 142 ----------------------------------------------------------- 0.632833 rattus - COG2152 Predicted glycosylase Cluster 143 ----------------------------------------------------------- 0.631750 polymerases - COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) 0.614078 crystallization - COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Cluster 144 ----------------------------------------------------------- 0.631561 enterococci - COG2606 Uncharacterized conserved protein Cluster 145 ----------------------------------------------------------- 0.631276 vinelandii - COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis 0.624583 vinelandii - COG0850 Septum formation inhibitor 0.613792 arthrobacter - COG1610 Uncharacterized conserved protein Cluster 146 ----------------------------------------------------------- 0.630932 betaine - COG1215 Glycosyltransferases, probably involved in cell wall biogenesis Cluster 147 ----------------------------------------------------------- 0.630557 lactation - COG3001 Fructosamine-3-kinase Cluster 148 ----------------------------------------------------------- 0.629595 dichroism - COG2105 Uncharacterized conserved protein 0.615706 hyperthermophiles - COG1203 Predicted helicases Cluster 149 ----------------------------------------------------------- 0.628995 assimilation - COG4674 Uncharacterized ABC-type transport system, ATPase component Cluster 150 ----------------------------------------------------------- 0.628638 toxigenic - COG2035 Predicted membrane protein 0.619059 enterotoxin - COG2035 Predicted membrane protein Cluster 151 ----------------------------------------------------------- 0.628419 sausage - COG0615 Cytidylyltransferase Cluster 152 ----------------------------------------------------------- 0.628168 tylosin - COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component Cluster 153 ----------------------------------------------------------- 0.627898 adhesin - COG0732 Restriction endonuclease S subunits 0.617011 adherence - COG0732 Restriction endonuclease S subunits Cluster 154 ----------------------------------------------------------- 0.627346 repression - COG0679 Predicted permeases Cluster 155 ----------------------------------------------------------- 0.626398 plastid - COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family Cluster 156 ----------------------------------------------------------- 0.626325 exopolysaccharide - COG3156 Type II secretory pathway, component PulK 0.620044 exopolysaccharide - COG3011 Uncharacterized protein conserved in bacteria Cluster 157 ----------------------------------------------------------- 0.626088 acinetobacter - COG3182 Uncharacterized iron-regulated membrane protein Cluster 158 ----------------------------------------------------------- 0.625009 opsonin - COG1566 Multidrug resistance efflux pump Cluster 159 ----------------------------------------------------------- 0.624783 brucellosis - COG3553 Uncharacterized protein conserved in bacteria Cluster 160 ----------------------------------------------------------- 0.623992 benzylpenicillin - COG3817 Predicted membrane protein 0.623992 benzylpenicillin - COG3819 Predicted membrane protein 0.621753 actinomyces - NOG15289 non supervised orthologous group 0.615894 benzylpenicillin - COG4929 Uncharacterized membrane-anchored protein Cluster 161 ----------------------------------------------------------- 0.623651 denitrificans - COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis Cluster 162 ----------------------------------------------------------- 0.623264 memory - COG1330 Exonuclease V gamma subunit Cluster 163 ----------------------------------------------------------- 0.623070 vancomycin - NOG14203 non supervised orthologous group 0.618732 bacteriuria - NOG14203 non supervised orthologous group 0.615907 neutropenia - NOG14203 non supervised orthologous group Cluster 164 ----------------------------------------------------------- 0.623067 germination - COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Cluster 165 ----------------------------------------------------------- 0.621406 amoxicillin - COG1636 Uncharacterized protein conserved in bacteria Cluster 166 ----------------------------------------------------------- 0.621146 biodegradation - COG2720 Uncharacterized vancomycin resistance protein Cluster 167 ----------------------------------------------------------- 0.621143 artery - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA Cluster 168 ----------------------------------------------------------- 0.621079 betaine - COG0702 Predicted nucleoside-diphosphate-sugar epimerases Cluster 169 ----------------------------------------------------------- 0.620852 animal - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase Cluster 170 ----------------------------------------------------------- 0.620716 cholesterol - NOG17873 non supervised orthologous group Cluster 171 ----------------------------------------------------------- 0.619869 cytosol - COG3459 Cellobiose phosphorylase Cluster 172 ----------------------------------------------------------- 0.619674 bacteriocin - COG4331 Predicted membrane protein Cluster 173 ----------------------------------------------------------- 0.619193 cereus - COG2382 Enterochelin esterase and related enzymes 0.613120 peptone - COG2807 Cyanate permease Cluster 174 ----------------------------------------------------------- 0.618887 lactate - COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Cluster 175 ----------------------------------------------------------- 0.618651 opsonin - NOG07935 non supervised orthologous group Cluster 176 ----------------------------------------------------------- 0.618374 biodegradation - COG3332 Uncharacterized conserved protein 0.614717 dioxygenase - COG3332 Uncharacterized conserved protein Cluster 177 ----------------------------------------------------------- 0.618210 oxacillin - COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Cluster 178 ----------------------------------------------------------- 0.617888 enterocolitis - COG3451 Type IV secretory pathway, VirB4 components 0.615835 colitis - COG3451 Type IV secretory pathway, VirB4 components Cluster 179 ----------------------------------------------------------- 0.617361 opsonin - COG2021 Homoserine acetyltransferase Cluster 180 ----------------------------------------------------------- 0.617124 malate - COG1910 Periplasmic molybdate-binding protein/domain 0.613480 megaterium - COG1873 Uncharacterized conserved protein Cluster 181 ----------------------------------------------------------- 0.616236 repair - COG1341 Predicted GTPase or GTP-binding protein 0.612872 repair - COG1818 Predicted RNA-binding protein, contains THUMP domain Cluster 182 ----------------------------------------------------------- 0.615461 fluorescens - COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4 Cluster 183 ----------------------------------------------------------- 0.614944 protoplast - COG2514 Predicted ring-cleavage extradiol dioxygenase Cluster 184 ----------------------------------------------------------- 0.614931 sorbitol - COG3727 DNA G:T-mismatch repair endonuclease Cluster 185 ----------------------------------------------------------- 0.614882 dichroism - COG2509 Uncharacterized FAD-dependent dehydrogenases Cluster 186 ----------------------------------------------------------- 0.613847 stenotrophomonas - COG3661 Alpha-glucuronidase Cluster 187 ----------------------------------------------------------- 0.613670 chromophore - COG2045 Phosphosulfolactate phosphohydrolase and related enzymes Cluster 188 ----------------------------------------------------------- 0.613401 enteritidis - COG3238 Uncharacterized protein conserved in bacteria Cluster 189 ----------------------------------------------------------- 0.612839 haemin - COG2978 Putative p-aminobenzoyl-glutamate transporter Cluster 190 ----------------------------------------------------------- 0.612727 empyema - COG2932 Predicted transcriptional regulator