# Table of significant word-OG associations # (prior to clustering, non-significant associations were removed) # # association_score word - OG OG_annotation # Cluster 1 ----------------------------------------------------------- 0.812172 vacuum - COG3933 Transcriptional antiterminator 0.808278 sausage - COG4869 Propanediol utilization protein 0.798619 starter - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.789747 starter - NOG08391 non supervised orthologous group 0.785647 vacuum - COG4869 Propanediol utilization protein 0.783999 starter - COG4909 Propanediol dehydratase, large subunit 0.783999 starter - COG4910 Propanediol dehydratase, small subunit 0.782693 sausage - COG4909 Propanediol dehydratase, large subunit 0.782693 sausage - COG4910 Propanediol dehydratase, small subunit 0.778675 bacteriocins - COG4905 Predicted membrane protein 0.774567 starter - COG4869 Propanediol utilization protein 0.773429 vegetable - COG4869 Propanediol utilization protein 0.754735 starter - COG4905 Predicted membrane protein 0.751404 bacteriocins - NOG08391 non supervised orthologous group 0.748810 sausage - COG3933 Transcriptional antiterminator 0.743894 lecithinase - COG4769 Predicted membrane protein 0.741232 spoilage - COG3933 Transcriptional antiterminator 0.740472 lecithinase - COG5341 Uncharacterized protein conserved in bacteria 0.740350 lecithinase - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.734639 sausage - NOG08391 non supervised orthologous group 0.730139 vacuum - COG4910 Propanediol dehydratase, small subunit 0.730139 vacuum - COG4909 Propanediol dehydratase, large subunit 0.729636 cheese - COG4194 Predicted membrane protein 0.726603 vegetable - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.726497 starter - COG4769 Predicted membrane protein 0.725313 bacteriocins - COG4910 Propanediol dehydratase, small subunit 0.725313 bacteriocins - COG4909 Propanediol dehydratase, large subunit 0.723889 enteritidis - COG4917 Ethanolamine utilization protein 0.723889 enteritidis - COG4816 Ethanolamine utilization protein 0.723889 enteritidis - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.723889 enteritidis - COG4810 Ethanolamine utilization protein 0.723044 enteritidis - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.722868 vacuum - NOG08391 non supervised orthologous group 0.722192 vegetable - COG4909 Propanediol dehydratase, large subunit 0.722192 vegetable - COG4910 Propanediol dehydratase, small subunit 0.722150 vacuum - COG4194 Predicted membrane protein 0.720872 starter - COG5341 Uncharacterized protein conserved in bacteria 0.719837 lecithinase - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.718706 bacteriocins - COG4832 Uncharacterized conserved protein 0.717487 bacteriocins - COG4194 Predicted membrane protein 0.717385 starter - COG3933 Transcriptional antiterminator 0.715636 monocytogene - COG4869 Propanediol utilization protein 0.715598 bacteriocins - COG5341 Uncharacterized protein conserved in bacteria 0.714275 spoilage - COG4194 Predicted membrane protein 0.713687 enteritidis - COG4869 Propanediol utilization protein 0.710021 cheese - COG4869 Propanediol utilization protein 0.708053 bacteriocins - COG4769 Predicted membrane protein 0.706186 spoilage - COG4869 Propanediol utilization protein 0.705676 vegetable - COG4917 Ethanolamine utilization protein 0.705676 vegetable - COG4810 Ethanolamine utilization protein 0.705676 vegetable - COG4816 Ethanolamine utilization protein 0.705676 vegetable - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.704793 bacteriocins - COG4869 Propanediol utilization protein 0.704097 bacteriocins - COG3933 Transcriptional antiterminator 0.703438 bacteriocin - COG4905 Predicted membrane protein 0.703413 monocytogene - COG3933 Transcriptional antiterminator 0.702468 lactobacillus - COG4194 Predicted membrane protein 0.701570 vegetable - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.700063 sausage - COG4769 Predicted membrane protein 0.697561 bacteriocins - COG3580 Uncharacterized protein conserved in bacteria 0.696646 sausage - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.696048 starter - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.695491 sausage - COG5341 Uncharacterized protein conserved in bacteria 0.693921 sausage - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.693920 sausage - COG4905 Predicted membrane protein 0.693894 vacuum - COG3426 Butyrate kinase 0.692620 spoilage - COG4769 Predicted membrane protein 0.691364 monocytogene - COG4910 Propanediol dehydratase, small subunit 0.691364 monocytogene - COG4909 Propanediol dehydratase, large subunit 0.691261 lecithinase - COG3581 Uncharacterized protein conserved in bacteria 0.685536 vegetable - COG3933 Transcriptional antiterminator 0.683912 lecithinase - COG3426 Butyrate kinase 0.682921 spoilage - COG3426 Butyrate kinase 0.682289 spoilage - COG5341 Uncharacterized protein conserved in bacteria 0.681854 lecithinase - COG3872 Predicted metal-dependent enzyme 0.680261 starter - COG4832 Uncharacterized conserved protein 0.679443 sausage - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.678184 vacuum - COG3192 Ethanolamine utilization protein 0.673026 gastroenteritis - COG4917 Ethanolamine utilization protein 0.673026 gastroenteritis - COG4810 Ethanolamine utilization protein 0.673026 gastroenteritis - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.673026 gastroenteritis - COG4816 Ethanolamine utilization protein 0.672159 spoilage - NOG08391 non supervised orthologous group 0.671601 starter - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.668530 spoilage - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.667931 bacteriocin - COG5341 Uncharacterized protein conserved in bacteria 0.667873 sausage - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.667873 sausage - COG4816 Ethanolamine utilization protein 0.667873 sausage - COG4917 Ethanolamine utilization protein 0.667873 sausage - COG4810 Ethanolamine utilization protein 0.667685 vacuum - COG4769 Predicted membrane protein 0.666502 monocytogene - COG4194 Predicted membrane protein 0.666345 vegetable - NOG08391 non supervised orthologous group 0.666327 bacteriocin - COG3580 Uncharacterized protein conserved in bacteria 0.665752 bacteriocins - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.665295 gastroenteritis - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.664266 vacuum - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.658932 bacteriocins - COG3581 Uncharacterized protein conserved in bacteria 0.658548 vacuum - COG5341 Uncharacterized protein conserved in bacteria 0.658542 bacteriocins - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.657748 starter - COG3580 Uncharacterized protein conserved in bacteria 0.657640 cheese - COG3933 Transcriptional antiterminator 0.657325 bacteriocin - COG4769 Predicted membrane protein 0.657234 cheese - NOG08391 non supervised orthologous group 0.655594 spoilage - COG3872 Predicted metal-dependent enzyme 0.654747 vacuum - COG4905 Predicted membrane protein 0.654743 cheese - COG4909 Propanediol dehydratase, large subunit 0.654743 cheese - COG4910 Propanediol dehydratase, small subunit 0.653763 bacteriocin - NOG08391 non supervised orthologous group 0.652875 vacuum - COG3584 Uncharacterized protein conserved in bacteria 0.650313 monocytogene - COG4905 Predicted membrane protein 0.649128 sausage - COG3580 Uncharacterized protein conserved in bacteria 0.649015 vacuum - COG3872 Predicted metal-dependent enzyme 0.648829 bacteriocin - COG4194 Predicted membrane protein 0.647382 vacuum - COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase 0.646168 starter - COG4194 Predicted membrane protein 0.644878 bacteriocin - COG3581 Uncharacterized protein conserved in bacteria 0.642023 spoilage - COG4905 Predicted membrane protein 0.641516 starter - COG4917 Ethanolamine utilization protein 0.641516 starter - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.641516 starter - COG4810 Ethanolamine utilization protein 0.641516 starter - COG4816 Ethanolamine utilization protein 0.640239 phospholipase - COG4769 Predicted membrane protein 0.640053 spoilage - COG3580 Uncharacterized protein conserved in bacteria 0.639790 vacuum - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.638615 starter - COG1930 ABC-type cobalt transport system, periplasmic component 0.638165 sausage - COG4194 Predicted membrane protein 0.637864 carcass - COG4869 Propanediol utilization protein 0.636102 gastroenteritis - COG4869 Propanediol utilization protein 0.634426 spoilage - COG3581 Uncharacterized protein conserved in bacteria 0.634168 spoilage - COG4910 Propanediol dehydratase, small subunit 0.634168 spoilage - COG4909 Propanediol dehydratase, large subunit 0.633783 lecithinase - NOG08391 non supervised orthologous group 0.633180 lecithinase - COG3580 Uncharacterized protein conserved in bacteria 0.632359 starter - COG3581 Uncharacterized protein conserved in bacteria 0.631886 vegetable - COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.630511 lecithinase - COG4905 Predicted membrane protein 0.629962 broiler - COG4769 Predicted membrane protein 0.628931 monocytogene - COG4832 Uncharacterized conserved protein 0.625273 gastroenteritis - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.624196 lecithinase - COG3933 Transcriptional antiterminator 0.623937 phospholipase - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.623572 phospholipase - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.623478 cheese - COG4905 Predicted membrane protein 0.622045 xylose - COG3584 Uncharacterized protein conserved in bacteria 0.621659 enteritidis - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.621301 sewage - COG4194 Predicted membrane protein 0.621166 vegetable - COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.621126 monocytogene - NOG08391 non supervised orthologous group 0.620860 sausage - COG4832 Uncharacterized conserved protein 0.619542 enteritidis - COG4909 Propanediol dehydratase, large subunit 0.619542 enteritidis - COG4910 Propanediol dehydratase, small subunit 0.619218 phospholipase - COG5341 Uncharacterized protein conserved in bacteria 0.618887 lactate - COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) 0.617380 sausage - COG4272 Predicted membrane protein 0.616982 broiler - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.615025 vegetable - COG3192 Ethanolamine utilization protein 0.613991 xylose - COG3426 Butyrate kinase 0.613868 coliforms - COG4194 Predicted membrane protein 0.613175 spoilage - COG3584 Uncharacterized protein conserved in bacteria 0.613058 enteritidis - COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.609173 bacteriocin - COG4832 Uncharacterized conserved protein 0.608618 cheese - COG4769 Predicted membrane protein 0.607854 phospholipase - NOG08391 non supervised orthologous group 0.607194 lactobacillus - COG4869 Propanediol utilization protein 0.606915 betaine - COG4194 Predicted membrane protein 0.605636 sewage - COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain 0.604555 vacuum - COG3580 Uncharacterized protein conserved in bacteria 0.603430 enteritidis - COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein 0.602209 cheese - COG5341 Uncharacterized protein conserved in bacteria 0.602105 carcass - COG4769 Predicted membrane protein 0.601314 enteritidis - COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase 0.600664 phospholipase - COG3426 Butyrate kinase 0.600551 poultry - COG4869 Propanediol utilization protein 0.599615 vegetable - COG4905 Predicted membrane protein 0.599334 cheese - COG3580 Uncharacterized protein conserved in bacteria 0.598238 peptone - NOG08391 non supervised orthologous group 0.597944 bacteriocin - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.597909 sludge - COG4302 Ethanolamine ammonia-lyase, small subunit 0.597909 sludge - COG4303 Ethanolamine ammonia-lyase, large subunit 0.597789 lactobacillus - COG4769 Predicted membrane protein 0.597585 vegetable - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.597284 lecithinase - COG4198 uncharacterized, maybe involved in chromosome particioning (prev. Uncharacterized conserved protein) 0.597268 phosphoprotein - COG4869 Propanediol utilization protein 0.596336 vacuum - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.596336 vacuum - COG4917 Ethanolamine utilization protein 0.596336 vacuum - COG4810 Ethanolamine utilization protein 0.596336 vacuum - COG4816 Ethanolamine utilization protein 0.595853 chicken - COG4816 Ethanolamine utilization protein 0.595853 chicken - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.595853 chicken - COG4917 Ethanolamine utilization protein 0.595853 chicken - COG4810 Ethanolamine utilization protein 0.595792 starter - COG3426 Butyrate kinase 0.595599 broiler - COG5341 Uncharacterized protein conserved in bacteria 0.595587 vegetable - COG4766 Ethanolamine utilization protein 0.595362 phospholipase - COG4198 uncharacterized, maybe involved in chromosome particioning (prev. Uncharacterized conserved protein) 0.595251 bacteriocin - COG3933 Transcriptional antiterminator 0.595126 cheese - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.593986 sewage - COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC 0.592384 chicken - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.592223 poultry - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.591915 propionate - NOG08391 non supervised orthologous group 0.591382 bacteriocin - COG4909 Propanediol dehydratase, large subunit 0.591382 bacteriocin - COG4910 Propanediol dehydratase, small subunit 0.591141 phosphoprotein - NOG08391 non supervised orthologous group 0.590140 sludge - NOG08391 non supervised orthologous group 0.590067 vacuum - COG4766 Ethanolamine utilization protein 0.589074 enteritidis - COG4303 Ethanolamine ammonia-lyase, large subunit 0.589074 enteritidis - COG4302 Ethanolamine ammonia-lyase, small subunit 0.589024 cheese - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.588083 enteritidis - COG2918 Gamma-glutamylcysteine synthetase 0.587893 peptone - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.587728 peptone - COG4869 Propanediol utilization protein 0.587696 sewage - COG2918 Gamma-glutamylcysteine synthetase 0.587655 carcass - COG4194 Predicted membrane protein 0.587456 lactobacillus - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.586453 propionate - COG4303 Ethanolamine ammonia-lyase, large subunit 0.586453 propionate - COG4302 Ethanolamine ammonia-lyase, small subunit 0.585002 starter - COG0310 ABC-type Co2+ transport system, permease component 0.584635 vegetable - COG4769 Predicted membrane protein 0.584581 vegetable - COG4194 Predicted membrane protein 0.584258 vegetable - COG4832 Uncharacterized conserved protein 0.583703 lactobacillus - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.583549 bacteriocins - COG4272 Predicted membrane protein 0.583520 phosphoprotein - COG4194 Predicted membrane protein 0.583513 enteritidis - COG4194 Predicted membrane protein 0.583092 bacteriocins - COG3426 Butyrate kinase 0.582354 spoilage - COG4812 Ethanolamine utilization cobalamin adenosyltransferase 0.582276 broiler - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.581082 propionate - COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol 0.581046 phospholipase - COG3933 Transcriptional antiterminator 0.580384 vegetable - COG1930 ABC-type cobalt transport system, periplasmic component 0.579531 spoilage - COG4939 Major membrane immunogen, membrane-anchored lipoprotein 0.579471 carcass - COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase 0.579318 lactobacillus - COG5341 Uncharacterized protein conserved in bacteria 0.578700 sewage - COG3933 Transcriptional antiterminator 0.577925 cheese - COG4832 Uncharacterized conserved protein 0.577207 poultry - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.577207 poultry - COG4816 Ethanolamine utilization protein 0.577207 poultry - COG4810 Ethanolamine utilization protein 0.577207 poultry - COG4917 Ethanolamine utilization protein 0.577129 peptone - COG3192 Ethanolamine utilization protein 0.576765 gastroenteritis - COG4769 Predicted membrane protein 0.575906 broiler - NOG08391 non supervised orthologous group 0.575802 poultry - NOG08391 non supervised orthologous group 0.574834 carcass - NOG08391 non supervised orthologous group 0.573832 carcass - COG5341 Uncharacterized protein conserved in bacteria 0.572266 phosphoprotein - COG3933 Transcriptional antiterminator 0.570615 peptone - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.570615 peptone - COG4810 Ethanolamine utilization protein 0.570615 peptone - COG4816 Ethanolamine utilization protein 0.570615 peptone - COG4917 Ethanolamine utilization protein 0.569719 propionate - COG4769 Predicted membrane protein 0.569355 lactobacillus - COG4810 Ethanolamine utilization protein 0.569355 lactobacillus - COG4917 Ethanolamine utilization protein 0.569355 lactobacillus - COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 0.569355 lactobacillus - COG4816 Ethanolamine utilization protein 0.568856 poultry - COG4769 Predicted membrane protein 0.568462 lecithinase - COG4869 Propanediol utilization protein Cluster 2 ----------------------------------------------------------- 0.808369 flagellin - COG1684 Flagellar biosynthesis pathway, component FliR 0.808369 flagellin - COG1987 Flagellar biosynthesis pathway, component FliQ 0.808369 flagellin - COG1868 Flagellar motor switch protein 0.808369 flagellin - COG1677 Flagellar hook-basal body protein 0.808369 flagellin - COG4786 Flagellar basal body rod protein 0.808369 flagellin - COG1815 Flagellar basal body protein 0.808369 flagellin - COG1843 Flagellar hook capping protein 0.806560 flagellin - COG1291 Flagellar motor component 0.806560 flagellin - COG1344 Flagellin and related hook-associated proteins 0.806560 flagellin - COG1360 Flagellar motor protein 0.800634 flagellin - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.800634 flagellin - COG1558 Flagellar basal body rod protein 0.792643 flagellin - COG1256 Flagellar hook-associated protein 0.791480 flagellum - COG1987 Flagellar biosynthesis pathway, component FliQ 0.791480 flagellum - COG1815 Flagellar basal body protein 0.791480 flagellum - COG4786 Flagellar basal body rod protein 0.791480 flagellum - COG1843 Flagellar hook capping protein 0.791480 flagellum - COG1868 Flagellar motor switch protein 0.791480 flagellum - COG1677 Flagellar hook-basal body protein 0.791480 flagellum - COG1684 Flagellar biosynthesis pathway, component FliR 0.789336 flagellum - COG1344 Flagellin and related hook-associated proteins 0.789336 flagellum - COG1291 Flagellar motor component 0.789336 flagellum - COG1360 Flagellar motor protein 0.788505 flagellum - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.788505 flagellum - COG1558 Flagellar basal body rod protein 0.766970 flagellum - COG1256 Flagellar hook-associated protein 0.751754 flagellin - COG1345 Flagellar capping protein 0.751754 flagellin - COG1516 Flagellin-specific chaperone FliS 0.733530 flagellin - COG1749 Flagellar hook protein FlgE 0.718323 flagellin - COG1377 Flagellar biosynthesis pathway, component FlhB 0.718323 flagellin - COG1298 Flagellar biosynthesis pathway, component FlhA 0.718323 flagellin - COG1338 Flagellar biosynthesis pathway, component FliP 0.718323 flagellin - COG1157 Flagellar biosynthesis/type III secretory pathway ATPase 0.711255 flagellin - COG1886 Flagellar motor switch/type III secretory pathway protein 0.703436 flagellum - COG1345 Flagellar capping protein 0.703436 flagellum - COG1516 Flagellin-specific chaperone FliS 0.697821 flagellin - COG1536 Flagellar motor switch protein 0.691695 flagellum - COG1749 Flagellar hook protein FlgE 0.682291 flagellum - COG1298 Flagellar biosynthesis pathway, component FlhA 0.682291 flagellum - COG1377 Flagellar biosynthesis pathway, component FlhB 0.682291 flagellum - COG1338 Flagellar biosynthesis pathway, component FliP 0.682291 flagellum - COG1157 Flagellar biosynthesis/type III secretory pathway ATPase 0.672903 flagellin - COG1419 Flagellar GTP-binding protein 0.667790 motility - COG1815 Flagellar basal body protein 0.667790 motility - COG1677 Flagellar hook-basal body protein 0.667790 motility - COG4786 Flagellar basal body rod protein 0.667790 motility - COG1868 Flagellar motor switch protein 0.667790 motility - COG1684 Flagellar biosynthesis pathway, component FliR 0.667790 motility - COG1987 Flagellar biosynthesis pathway, component FliQ 0.667790 motility - COG1843 Flagellar hook capping protein 0.663896 motility - COG1558 Flagellar basal body rod protein 0.663896 motility - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.651899 motility - COG1256 Flagellar hook-associated protein 0.651062 flagellum - COG1536 Flagellar motor switch protein 0.648977 flagellum - COG1886 Flagellar motor switch/type III secretory pathway protein 0.645663 flagellum - COG1706 Flagellar basal-body P-ring protein 0.641991 flagellum - COG1419 Flagellar GTP-binding protein 0.637074 flagellum - COG1261 Flagellar basal body P-ring biosynthesis protein 0.637074 flagellum - COG2063 Flagellar basal body L-ring protein 0.636647 motility - COG1749 Flagellar hook protein FlgE 0.634989 flagellum - COG0835 Chemotaxis signal transduction protein 0.629791 flagellin - COG0835 Chemotaxis signal transduction protein 0.629443 flagellum - COG0643 Chemotaxis protein histidine kinase and related kinases 0.627454 motility - COG1344 Flagellin and related hook-associated proteins 0.627454 motility - COG1360 Flagellar motor protein 0.627454 motility - COG1291 Flagellar motor component 0.623485 flagellin - COG0643 Chemotaxis protein histidine kinase and related kinases 0.618740 flagellum - COG1580 Flagellar basal body-associated protein 0.616952 flagellin - COG1706 Flagellar basal-body P-ring protein 0.612868 flagellin - COG1261 Flagellar basal body P-ring biosynthesis protein 0.612868 flagellin - COG2063 Flagellar basal body L-ring protein 0.612191 filament - COG1815 Flagellar basal body protein 0.612191 filament - COG1684 Flagellar biosynthesis pathway, component FliR 0.612191 filament - COG1868 Flagellar motor switch protein 0.612191 filament - COG1987 Flagellar biosynthesis pathway, component FliQ 0.612191 filament - COG1843 Flagellar hook capping protein 0.612191 filament - COG4786 Flagellar basal body rod protein 0.612191 filament - COG1677 Flagellar hook-basal body protein 0.611857 filament - COG1749 Flagellar hook protein FlgE 0.604074 promoter - COG0840 Methyl-accepting chemotaxis protein 0.599466 filament - COG1291 Flagellar motor component 0.599466 filament - COG1360 Flagellar motor protein 0.599466 filament - COG1344 Flagellin and related hook-associated proteins 0.597190 filament - COG1558 Flagellar basal body rod protein 0.597190 filament - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.593145 proteobacteria - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.593145 proteobacteria - COG1558 Flagellar basal body rod protein 0.589464 proteobacteria - COG1256 Flagellar hook-associated protein 0.588992 methyltransferase - COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain 0.588628 motility - COG1516 Flagellin-specific chaperone FliS 0.588628 motility - COG1345 Flagellar capping protein 0.587930 operator - COG1684 Flagellar biosynthesis pathway, component FliR 0.587930 operator - COG4786 Flagellar basal body rod protein 0.587930 operator - COG1868 Flagellar motor switch protein 0.587930 operator - COG1815 Flagellar basal body protein 0.587930 operator - COG1677 Flagellar hook-basal body protein 0.587930 operator - COG1987 Flagellar biosynthesis pathway, component FliQ 0.587930 operator - COG1843 Flagellar hook capping protein 0.587469 flagellin - COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation 0.586092 operator - COG1344 Flagellin and related hook-associated proteins 0.586092 operator - COG1291 Flagellar motor component 0.586092 operator - COG1360 Flagellar motor protein 0.585002 flagellin - COG1580 Flagellar basal body-associated protein 0.582201 operator - COG1558 Flagellar basal body rod protein 0.582201 operator - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.580655 proteobacteria - COG1868 Flagellar motor switch protein 0.580655 proteobacteria - COG1677 Flagellar hook-basal body protein 0.580655 proteobacteria - COG1684 Flagellar biosynthesis pathway, component FliR 0.580655 proteobacteria - COG1843 Flagellar hook capping protein 0.580655 proteobacteria - COG1815 Flagellar basal body protein 0.580655 proteobacteria - COG4786 Flagellar basal body rod protein 0.580655 proteobacteria - COG1987 Flagellar biosynthesis pathway, component FliQ 0.576646 operator - COG1256 Flagellar hook-associated protein 0.575814 replicon - COG1256 Flagellar hook-associated protein 0.574531 filament - COG1256 Flagellar hook-associated protein 0.574502 regulon - COG1344 Flagellin and related hook-associated proteins 0.574502 regulon - COG1360 Flagellar motor protein 0.574502 regulon - COG1291 Flagellar motor component 0.572021 motility - COG0835 Chemotaxis signal transduction protein 0.570616 proton - COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation Cluster 3 ----------------------------------------------------------- 0.807206 difficile - NOG09246 non supervised orthologous group 0.767427 metronidazole - NOG19912 non supervised orthologous group 0.749042 difficile - NOG28580 non supervised orthologous group 0.737211 difficile - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.734765 difficile - NOG19912 non supervised orthologous group 0.732521 difficile - COG3877 Uncharacterized protein conserved in bacteria 0.719341 difficile - COG1655 Uncharacterized protein conserved in bacteria 0.718836 cytotoxin - NOG19912 non supervised orthologous group 0.718068 hamster - NOG14615 non supervised orthologous group 0.708965 difficile - COG1433 Uncharacterized conserved protein 0.704578 metronidazole - NOG09246 non supervised orthologous group 0.698020 difficile - COG3968 Uncharacterized protein related to glutamine synthetase 0.696191 antitoxin - NOG09246 non supervised orthologous group 0.695087 metronidazole - COG5015 Uncharacterized conserved protein 0.690932 difficile - COG1243 Histone acetyltransferase 0.682126 difficile - COG3862 Uncharacterized protein with conserved CXXC pairs 0.680182 difficile - COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.679867 antitoxin - COG1433 Uncharacterized conserved protein 0.676715 enterocolitis - NOG09246 non supervised orthologous group 0.674914 hamster - COG1655 Uncharacterized protein conserved in bacteria 0.660442 antitoxin - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.651699 enterocolitis - COG3877 Uncharacterized protein conserved in bacteria 0.649666 enterocolitis - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.648991 colitis - NOG19912 non supervised orthologous group 0.640913 enterocolitis - COG1151 6Fe-6S prismane cluster-containing protein 0.636919 metronidazole - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.636573 enteritis - NOG19912 non supervised orthologous group 0.636077 metronidazole - COG3877 Uncharacterized protein conserved in bacteria 0.635967 antitoxin - COG1243 Histone acetyltransferase 0.630420 enterocolitis - COG3968 Uncharacterized protein related to glutamine synthetase 0.624169 stomach - NOG19912 non supervised orthologous group 0.624080 metronidazole - COG1655 Uncharacterized protein conserved in bacteria 0.621315 antitoxin - NOG28580 non supervised orthologous group 0.620466 metronidazole - COG3968 Uncharacterized protein related to glutamine synthetase 0.619487 enterocolitis - COG3862 Uncharacterized protein with conserved CXXC pairs 0.616846 enterocolitis - NOG28580 non supervised orthologous group 0.612529 colitis - COG1655 Uncharacterized protein conserved in bacteria 0.610216 antitoxin - COG4624 Iron only hydrogenase large subunit, C-terminal domain 0.610175 metronidazole - NOG28580 non supervised orthologous group 0.607575 colitis - NOG09246 non supervised orthologous group 0.607172 spirochaete - NOG14615 non supervised orthologous group 0.599413 metronidazole - COG1243 Histone acetyltransferase 0.597244 metronidazole - COG1433 Uncharacterized conserved protein 0.595976 metronidazole - COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.594557 colitis - COG1151 6Fe-6S prismane cluster-containing protein 0.592986 metronidazole - COG3875 Uncharacterized conserved protein 0.586955 cytotoxin - COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.585231 diarrhoea - NOG19912 non supervised orthologous group 0.585059 cytotoxin - COG1655 Uncharacterized protein conserved in bacteria 0.583212 spirochaete - COG1655 Uncharacterized protein conserved in bacteria 0.581040 hamster - NOG26813 non supervised orthologous group 0.570563 piglet - NOG14615 non supervised orthologous group 0.569912 cytotoxin - NOG09246 non supervised orthologous group Cluster 4 ----------------------------------------------------------- 0.807042 transferrin - COG3219 Uncharacterized protein conserved in bacteria 0.778153 postvaccination - COG3219 Uncharacterized protein conserved in bacteria 0.778121 lipooligosaccharide - COG3219 Uncharacterized protein conserved in bacteria 0.770463 lipooligosaccharides - COG3219 Uncharacterized protein conserved in bacteria 0.742396 transferrin - COG3778 Uncharacterized protein conserved in bacteria 0.734457 vaccinees - COG3778 Uncharacterized protein conserved in bacteria 0.729867 transferrin - COG3767 Uncharacterized low-complexity protein 0.692605 vaccinees - COG3203 Outer membrane protein (porin) 0.692068 postvaccination - COG2965 Primosomal replication protein N 0.689694 meningitis - COG3219 Uncharacterized protein conserved in bacteria 0.686638 vaccinees - COG5007 Predicted transcriptional regulator, BolA superfamily 0.683441 transferrin - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.678423 vaccinees - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.674154 transferrin - COG5007 Predicted transcriptional regulator, BolA superfamily 0.673030 transferrin - COG2965 Primosomal replication protein N 0.672394 lipooligosaccharide - COG3767 Uncharacterized low-complexity protein 0.668871 transferrin - COG3203 Outer membrane protein (porin) 0.667361 multilocus - COG2965 Primosomal replication protein N 0.666090 lipooligosaccharides - COG3767 Uncharacterized low-complexity protein 0.663629 postvaccination - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.656626 transferrin - COG3171 Uncharacterized protein conserved in bacteria 0.656562 lipooligosaccharide - COG2965 Primosomal replication protein N 0.655564 multilocus - COG3219 Uncharacterized protein conserved in bacteria 0.653393 postvaccination - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.653045 vaccinees - COG2914 Uncharacterized protein conserved in bacteria 0.652966 transferrin - COG2995 Uncharacterized paraquat-inducible protein A 0.651916 postvaccination - COG2914 Uncharacterized protein conserved in bacteria 0.650539 postvaccination - COG3203 Outer membrane protein (porin) 0.649830 postvaccination - COG3767 Uncharacterized low-complexity protein 0.648713 transferrin - COG5339 putative exported or periplasmic protein (prev: Uncharacterized protein conserved in bacteria) 0.648353 vaccinees - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.646817 transferrin - COG2990 Uncharacterized protein conserved in bacteria 0.644263 transferrin - COG3471 Predicted periplasmic/secreted protein 0.638754 vaccinees - COG3063 Tfp pilus assembly protein PilF 0.638505 lipooligosaccharides - COG2965 Primosomal replication protein N 0.633605 fatality - COG3778 Uncharacterized protein conserved in bacteria 0.633301 vaccinees - COG2924 Fe-S cluster protector protein 0.633301 vaccinees - COG2976 Uncharacterized protein conserved in bacteria 0.633239 postvaccination - COG2995 Uncharacterized paraquat-inducible protein A 0.631219 meningitis - COG3767 Uncharacterized low-complexity protein 0.628168 lipooligosaccharides - COG3778 Uncharacterized protein conserved in bacteria 0.626669 transferrin - COG3008 Paraquat-inducible protein B 0.626669 transferrin - COG3317 Uncharacterized lipoprotein 0.625355 postvaccination - COG2956 Predicted N-acetylglucosaminyl transferase 0.625355 postvaccination - COG3113 Predicted NTP binding protein (contains STAS domain) 0.624114 fatality - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.623310 lipooligosaccharide - COG3778 Uncharacterized protein conserved in bacteria 0.623264 memory - COG1330 Exonuclease V gamma subunit 0.622147 vaccinees - COG2921 Uncharacterized conserved protein 0.622147 vaccinees - COG2901 Factor for inversion stimulation Fis, transcriptional activator 0.621588 vaccinees - COG3219 Uncharacterized protein conserved in bacteria 0.620179 meningitis - COG3778 Uncharacterized protein conserved in bacteria 0.619384 postvaccination - COG3778 Uncharacterized protein conserved in bacteria 0.616306 meningitis - COG5007 Predicted transcriptional regulator, BolA superfamily 0.616154 tetanus - COG3219 Uncharacterized protein conserved in bacteria 0.615988 chemoprophylaxis - COG3778 Uncharacterized protein conserved in bacteria 0.613942 transferrin - COG2914 Uncharacterized protein conserved in bacteria 0.611838 vaccinees - COG4535 Putative Mg2+ and Co2+ transporter CorC 0.610595 lipooligosaccharide - COG2990 Uncharacterized protein conserved in bacteria 0.609151 transferrin - COG3312 F0F1-type ATP synthase, subunit I 0.607810 postvaccination - COG5007 Predicted transcriptional regulator, BolA superfamily 0.607649 lipooligosaccharides - COG2990 Uncharacterized protein conserved in bacteria 0.606548 lipooligosaccharide - COG3203 Outer membrane protein (porin) 0.606492 transferrin - COG3063 Tfp pilus assembly protein PilF 0.604979 vaccinees - COG2995 Uncharacterized paraquat-inducible protein A 0.601630 lipooligosaccharides - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.601484 vaccinees - COG3171 Uncharacterized protein conserved in bacteria 0.600845 transferrin - COG2901 Factor for inversion stimulation Fis, transcriptional activator 0.600845 transferrin - COG2921 Uncharacterized conserved protein 0.599519 transferrin - COG4259 Uncharacterized protein conserved in bacteria 0.599519 transferrin - COG4380 Uncharacterized protein conserved in bacteria 0.599161 tetanus - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.597796 vaccinees - COG3312 F0F1-type ATP synthase, subunit I 0.595951 vaccinees - COG1965 Protein implicated in iron transport, frataxin homolog 0.595910 transferrin - COG2976 Uncharacterized protein conserved in bacteria 0.595910 transferrin - COG2924 Fe-S cluster protector protein 0.593327 postvaccination - COG2990 Uncharacterized protein conserved in bacteria 0.592102 vaccinees - COG2965 Primosomal replication protein N 0.590160 lipooligosaccharides - COG3203 Outer membrane protein (porin) 0.589549 postvaccination - COG2924 Fe-S cluster protector protein 0.589549 postvaccination - COG2976 Uncharacterized protein conserved in bacteria 0.589416 lipooligosaccharide - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.586349 postvaccination - COG5339 putative exported or periplasmic protein (prev: Uncharacterized protein conserved in bacteria) 0.586069 vaccinees - COG3017 Outer membrane lipoprotein involved in outer membrane biogenesis 0.586069 vaccinees - COG3117 Uncharacterized protein conserved in bacteria 0.585079 meningitis - COG3215 Tfp pilus assembly protein PilZ 0.584067 lipooligosaccharide - COG2995 Uncharacterized paraquat-inducible protein A 0.583810 lipooligosaccharide - COG5007 Predicted transcriptional regulator, BolA superfamily 0.580013 meningitis - COG2976 Uncharacterized protein conserved in bacteria 0.580013 meningitis - COG2924 Fe-S cluster protector protein 0.579297 chemoprophylaxis - COG2991 putative exported or periplasmic protein (previously: Uncharacterized protein conserved in bacteria) 0.578291 meningitis - COG3203 Outer membrane protein (porin) 0.578158 vaccinees - COG3036 Uncharacterized protein conserved in bacteria 0.575387 lipooligosaccharides - COG2995 Uncharacterized paraquat-inducible protein A 0.573374 vaccinees - COG2956 Predicted N-acetylglucosaminyl transferase 0.573374 vaccinees - COG3113 Predicted NTP binding protein (contains STAS domain) 0.571537 africa - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.571307 meningitis - COG2914 Uncharacterized protein conserved in bacteria 0.570808 fatality - COG3063 Tfp pilus assembly protein PilF Cluster 5 ----------------------------------------------------------- 0.802693 vegetation - COG4413 Urea transporter 0.758817 silicone - COG4413 Urea transporter 0.744128 amikacin - COG4413 Urea transporter 0.707047 cornea - COG4413 Urea transporter 0.693175 implant - COG4413 Urea transporter 0.687709 prosthesis - COG4413 Urea transporter 0.683271 coagulase - COG4413 Urea transporter 0.673030 fibrosis - COG4413 Urea transporter 0.655227 gentamicin - COG4413 Urea transporter 0.653778 dermatitis - COG4413 Urea transporter 0.653192 osteomyelitis - COG4413 Urea transporter 0.637652 vegetation - COG3477 Predicted periplasmic/secreted protein 0.636546 ointment - COG4413 Urea transporter 0.632761 cefoperazone - COG4413 Urea transporter 0.609980 device - COG4413 Urea transporter 0.599298 disinfection - COG4413 Urea transporter 0.597918 chlorhexidine - COG4413 Urea transporter 0.596511 cefazolin - COG4413 Urea transporter 0.594513 disinfectant - COG4413 Urea transporter 0.594004 prosthesis - COG3477 Predicted periplasmic/secreted protein 0.593156 healing - COG3477 Predicted periplasmic/secreted protein 0.588655 biofilms - COG4413 Urea transporter 0.578985 silicone - COG3477 Predicted periplasmic/secreted protein 0.577516 amikacin - COG3477 Predicted periplasmic/secreted protein 0.577283 vegetation - COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog 0.575079 coagulase - COG3477 Predicted periplasmic/secreted protein 0.573988 implantation - COG4413 Urea transporter 0.571290 bypass - COG3477 Predicted periplasmic/secreted protein 0.569516 enterobacter - COG4413 Urea transporter 0.568867 healing - COG4413 Urea transporter Cluster 6 ----------------------------------------------------------- 0.801993 silicone - COG4270 Predicted membrane protein 0.758432 device - COG4270 Predicted membrane protein 0.729488 implant - COG4270 Predicted membrane protein 0.720146 cornea - COG4270 Predicted membrane protein 0.718603 silicone - COG3296 Uncharacterized protein conserved in bacteria 0.717438 osteomyelitis - COG4732 Predicted membrane protein 0.715262 implant - COG4492 ACT domain-containing protein 0.703326 implant - COG4495 Uncharacterized protein conserved in bacteria 0.693614 catheter - COG3002 Uncharacterized protein conserved in bacteria 0.686688 vegetation - COG4270 Predicted membrane protein 0.681770 implant - COG4732 Predicted membrane protein 0.679570 chlorhexidine - COG4270 Predicted membrane protein 0.679190 silicone - NOG07926 non supervised orthologous group 0.678242 prosthesis - COG4270 Predicted membrane protein 0.671331 dermatitis - COG4270 Predicted membrane protein 0.669031 cornea - COG2314 Predicted membrane protein, and no convincing STRING links 0.665327 haemolyticus - COG4732 Predicted membrane protein 0.659804 catheter - COG4270 Predicted membrane protein 0.659307 prosthesis - COG3002 Uncharacterized protein conserved in bacteria 0.655460 cefazolin - COG4732 Predicted membrane protein 0.654286 prosthesis - COG4333 Uncharacterized protein conserved in bacteria 0.648123 silicone - COG4492 ACT domain-containing protein 0.645016 silicone - COG3002 Uncharacterized protein conserved in bacteria 0.643491 implant - COG3002 Uncharacterized protein conserved in bacteria 0.642246 catheter - COG3296 Uncharacterized protein conserved in bacteria 0.642231 catheter - COG4732 Predicted membrane protein 0.641809 osteomyelitis - COG4495 Uncharacterized protein conserved in bacteria 0.641673 silicone - COG4495 Uncharacterized protein conserved in bacteria 0.641397 cornea - COG3296 Uncharacterized protein conserved in bacteria 0.640928 implant - COG4333 Uncharacterized protein conserved in bacteria 0.640493 silicone - COG2314 Predicted membrane protein, and no convincing STRING links 0.639205 silicone - COG2602 Beta-lactamase class D 0.637836 dermatitis - COG4732 Predicted membrane protein 0.636532 implant - NOG07926 non supervised orthologous group 0.636524 implant - COG3949 Uncharacterized membrane protein 0.636080 implant - COG3296 Uncharacterized protein conserved in bacteria 0.633037 dermatitis - COG3002 Uncharacterized protein conserved in bacteria 0.632385 implantation - NOG07926 non supervised orthologous group 0.629548 device - COG2602 Beta-lactamase class D 0.628101 silicone - COG4333 Uncharacterized protein conserved in bacteria 0.627493 osteomyelitis - COG4270 Predicted membrane protein 0.625995 ointment - COG4270 Predicted membrane protein 0.623631 vegetation - COG3002 Uncharacterized protein conserved in bacteria 0.623387 dermatitis - NOG07935 non supervised orthologous group 0.623357 implantation - COG4270 Predicted membrane protein 0.618523 ointment - COG3949 Uncharacterized membrane protein 0.617620 silicone - COG4732 Predicted membrane protein 0.617512 device - COG2314 Predicted membrane protein, and no convincing STRING links 0.617164 implant - NOG08620 non supervised orthologous group 0.616679 device - COG3949 Uncharacterized membrane protein 0.615365 osteomyelitis - COG4333 Uncharacterized protein conserved in bacteria 0.615301 surgery - COG4732 Predicted membrane protein 0.613477 vegetation - COG4732 Predicted membrane protein 0.613028 coagulase - COG4732 Predicted membrane protein 0.611855 fibrosis - COG3296 Uncharacterized protein conserved in bacteria 0.611190 catheter - COG4495 Uncharacterized protein conserved in bacteria 0.610202 implantation - COG4333 Uncharacterized protein conserved in bacteria 0.609726 prosthesis - COG1510 Predicted transcriptional regulators 0.609626 chlorhexidine - COG3002 Uncharacterized protein conserved in bacteria 0.606313 device - COG4495 Uncharacterized protein conserved in bacteria 0.605950 haemolyticus - COG4270 Predicted membrane protein 0.604944 oxacillin - COG4732 Predicted membrane protein 0.604175 cornea - NOG07926 non supervised orthologous group 0.604133 implant - COG1510 Predicted transcriptional regulators 0.603792 cefazolin - COG4495 Uncharacterized protein conserved in bacteria 0.602973 acinetobacter - COG3949 Uncharacterized membrane protein 0.602404 implant - NOG07935 non supervised orthologous group 0.602383 chlorhexidine - COG4495 Uncharacterized protein conserved in bacteria 0.601953 prosthesis - NOG07926 non supervised orthologous group 0.600022 implantation - COG3002 Uncharacterized protein conserved in bacteria 0.599894 catheter - COG4333 Uncharacterized protein conserved in bacteria 0.599882 healing - COG3002 Uncharacterized protein conserved in bacteria 0.597633 implantation - COG4732 Predicted membrane protein 0.596410 implantation - COG4492 ACT domain-containing protein 0.595885 haemolyticus - COG3002 Uncharacterized protein conserved in bacteria 0.595575 dermatitis - COG2602 Beta-lactamase class D 0.594188 coagulase - COG4495 Uncharacterized protein conserved in bacteria 0.593925 oxacillin - COG3002 Uncharacterized protein conserved in bacteria 0.593887 oxacillin - COG4270 Predicted membrane protein 0.591259 silicone - NOG07935 non supervised orthologous group 0.591029 chlorhexidine - COG3949 Uncharacterized membrane protein 0.591018 oxacillin - NOG07935 non supervised orthologous group 0.590774 implantation - COG4495 Uncharacterized protein conserved in bacteria 0.588170 cefazolin - COG3949 Uncharacterized membrane protein 0.587877 device - COG3296 Uncharacterized protein conserved in bacteria 0.587872 bypass - COG4270 Predicted membrane protein 0.587242 prosthesis - NOG07935 non supervised orthologous group 0.586822 prosthesis - COG4495 Uncharacterized protein conserved in bacteria 0.585635 cornea - COG2602 Beta-lactamase class D 0.585611 silicone - COG1510 Predicted transcriptional regulators 0.584582 surgery - COG4492 ACT domain-containing protein 0.584482 catheter - COG3949 Uncharacterized membrane protein 0.583599 prosthesis - COG4732 Predicted membrane protein 0.583504 dermatitis - COG4333 Uncharacterized protein conserved in bacteria 0.583248 osteomyelitis - COG3002 Uncharacterized protein conserved in bacteria 0.582434 enterobacter - COG3949 Uncharacterized membrane protein 0.581482 bypass - COG3002 Uncharacterized protein conserved in bacteria 0.581034 chlorhexidine - COG3296 Uncharacterized protein conserved in bacteria 0.580781 biofilm - COG4270 Predicted membrane protein 0.580046 device - COG3638 ABC-type phosphate/phosphonate transport system, ATPase component 0.579970 device - NOG07935 non supervised orthologous group 0.579242 osteomyelitis - NOG07935 non supervised orthologous group 0.579016 dermatitis - COG3296 Uncharacterized protein conserved in bacteria 0.578976 silicone - COG3949 Uncharacterized membrane protein 0.578861 implantation - COG3949 Uncharacterized membrane protein 0.578438 vegetation - COG1510 Predicted transcriptional regulators 0.577208 prosthesis - COG3296 Uncharacterized protein conserved in bacteria 0.577015 chlorhexidine - NOG07935 non supervised orthologous group 0.575702 vegetation - COG4495 Uncharacterized protein conserved in bacteria 0.575176 haemolyticus - COG4495 Uncharacterized protein conserved in bacteria 0.574422 osteomyelitis - NOG08620 non supervised orthologous group 0.573656 healing - COG4732 Predicted membrane protein 0.573400 device - COG4619 ABC-type uncharacterized transport system, ATPase component 0.571766 implant - COG3944 Capsular polysaccharide biosynthesis protein 0.571739 implant - COG2445 Uncharacterized conserved protein 0.571056 chlorhexidine - COG4732 Predicted membrane protein 0.570443 coagulase - COG4270 Predicted membrane protein 0.570258 healing - COG4270 Predicted membrane protein 0.570111 fibrinogen - COG4732 Predicted membrane protein 0.569049 surgery - COG4495 Uncharacterized protein conserved in bacteria Cluster 7 ----------------------------------------------------------- 0.798838 monocytogene - NOG08857 non supervised orthologous group 0.742872 phosphoprotein - COG4748 Uncharacterized conserved protein 0.727019 sausage - NOG08857 non supervised orthologous group 0.713063 vegetable - COG4748 Uncharacterized conserved protein 0.707201 starter - NOG26407 non supervised orthologous group 0.688981 starter - COG4748 Uncharacterized conserved protein 0.688565 vegetable - COG3592 Uncharacterized conserved protein 0.682655 cheese - NOG08857 non supervised orthologous group 0.678769 sausage - NOG26407 non supervised orthologous group 0.677338 cheese - COG4748 Uncharacterized conserved protein 0.672003 monocytogene - COG4912 Predicted DNA alkylation repair enzyme 0.668987 bacteriocins - NOG26407 non supervised orthologous group 0.666443 betaine - COG4748 Uncharacterized conserved protein 0.664461 starter - COG3592 Uncharacterized conserved protein 0.659901 phosphoprotein - COG4091 Predicted homoserine dehydrogenase 0.659681 sausage - NOG26249 non supervised orthologous group 0.659193 sausage - COG3592 Uncharacterized conserved protein 0.655415 vegetable - COG4091 Predicted homoserine dehydrogenase 0.654639 bacteriocins - COG4748 Uncharacterized conserved protein 0.654427 enteritidis - NOG08857 non supervised orthologous group 0.652316 bacteriocins - COG4912 Predicted DNA alkylation repair enzyme 0.649306 sausage - COG4834 Uncharacterized protein conserved in bacteria 0.644407 sausage - COG4748 Uncharacterized conserved protein 0.642992 vacuum - COG4748 Uncharacterized conserved protein 0.642771 vegetable - COG3732 Phosphotransferase system sorbitol-specific component IIBC 0.642525 monocytogene - COG4834 Uncharacterized protein conserved in bacteria 0.642263 vegetable - COG3730 Phosphotransferase system sorbitol-specific component IIC 0.639121 bacteriocins - COG4767 Glycopeptide antibiotics resistance protein 0.630344 cheese - COG4912 Predicted DNA alkylation repair enzyme 0.630252 vegetable - COG3731 Phosphotransferase system sorbitol-specific component IIA 0.623965 starter - COG4834 Uncharacterized protein conserved in bacteria 0.618063 vacuum - COG4091 Predicted homoserine dehydrogenase 0.617525 bacteriocins - NOG08857 non supervised orthologous group 0.617331 bacteriocins - COG2848 Uncharacterized conserved protein 0.614571 monocytogene - NOG26249 non supervised orthologous group 0.603714 starter - COG4091 Predicted homoserine dehydrogenase 0.598301 spoilage - COG4748 Uncharacterized conserved protein 0.595974 starter - COG5361 Uncharacterized conserved protein 0.589318 starter - NOG08857 non supervised orthologous group 0.588219 vegetable - NOG08857 non supervised orthologous group 0.587807 cheese - NOG26249 non supervised orthologous group 0.586902 cheese - NOG26407 non supervised orthologous group 0.586625 starter - NOG26249 non supervised orthologous group 0.581305 spoilage - NOG08857 non supervised orthologous group 0.578261 bacteriocin - COG4912 Predicted DNA alkylation repair enzyme 0.575563 cheese - COG4091 Predicted homoserine dehydrogenase 0.574469 lactate - COG2848 Uncharacterized conserved protein 0.573003 bacteriocin - COG4767 Glycopeptide antibiotics resistance protein 0.572664 peptone - COG4748 Uncharacterized conserved protein 0.569950 bacteriocins - COG5361 Uncharacterized conserved protein Cluster 8 ----------------------------------------------------------- 0.798477 chlorophyll - NOG14127 non supervised orthologous group 0.798477 chlorophyll - NOG09697 non supervised orthologous group 0.793777 cyanobacteria - NOG12317 non supervised orthologous group 0.793301 cyanobacteria - COG4995 Uncharacterized protein conserved in bacteria 0.788735 photosystem - COG4995 Uncharacterized protein conserved in bacteria 0.788313 photosynthesis - COG4995 Uncharacterized protein conserved in bacteria 0.785247 chlorophyll - NOG10341 non supervised orthologous group 0.779015 photosystem - NOG10341 non supervised orthologous group 0.778547 cyanobacteria - NOG10341 non supervised orthologous group 0.774722 flavodoxin - COG3330 Uncharacterized protein conserved in bacteria 0.772113 photosystem - NOG09697 non supervised orthologous group 0.772113 photosystem - NOG14127 non supervised orthologous group 0.767081 cyanobacteria - NOG09697 non supervised orthologous group 0.767081 cyanobacteria - NOG14127 non supervised orthologous group 0.765686 photosynthesis - NOG10341 non supervised orthologous group 0.758190 flavodoxin - COG2052 Uncharacterized protein conserved in bacteria 0.757079 chlorophyll - COG3330 Uncharacterized protein conserved in bacteria 0.755475 chlorophyll - NOG10533 non supervised orthologous group 0.755475 chlorophyll - NOG13226 non supervised orthologous group 0.751391 photosynthesis - NOG14127 non supervised orthologous group 0.751391 photosynthesis - NOG09697 non supervised orthologous group 0.741613 photosystem - NOG10533 non supervised orthologous group 0.741613 photosystem - NOG13226 non supervised orthologous group 0.726849 flavodoxin - COG4242 Cyanophycinase and related exopeptidases 0.725593 photosynthesis - NOG10533 non supervised orthologous group 0.725593 photosynthesis - NOG13226 non supervised orthologous group 0.696452 flavodoxin - NOG09697 non supervised orthologous group 0.696452 flavodoxin - NOG14127 non supervised orthologous group 0.695584 variabilis - COG5322 Predicted dehydrogenase 0.689196 variabilis - COG4995 Uncharacterized protein conserved in bacteria 0.678351 variabilis - NOG14127 non supervised orthologous group 0.678351 variabilis - NOG09697 non supervised orthologous group 0.673368 chloroplast - COG5401 Spore germination protein 0.669988 flavodoxin - NOG10341 non supervised orthologous group 0.667910 variabilis - NOG09669 non supervised orthologous group 0.667910 variabilis - COG4370 Uncharacterized protein conserved in bacteria 0.666212 variabilis - COG3330 Uncharacterized protein conserved in bacteria 0.659479 flavodoxin - COG5322 Predicted dehydrogenase 0.652305 thuringiensis - COG5401 Spore germination protein 0.651335 variabilis - COG4250 Predicted sensor protein/domain 0.650296 ferredoxins - COG2052 Uncharacterized protein conserved in bacteria 0.648056 variabilis - COG4242 Cyanophycinase and related exopeptidases 0.644233 flavodoxin - COG1453 Predicted oxidoreductases of the aldo/keto reductase family 0.643936 variabilis - NOG12317 non supervised orthologous group 0.643514 variabilis - NOG10341 non supervised orthologous group 0.640093 flavodoxin - NOG10533 non supervised orthologous group 0.640093 flavodoxin - NOG13226 non supervised orthologous group 0.639771 chloroplast - COG3330 Uncharacterized protein conserved in bacteria 0.634190 ferredoxin - COG2052 Uncharacterized protein conserved in bacteria 0.632709 flavodoxin - COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component 0.631976 chloroplast - NOG12317 non supervised orthologous group 0.630273 flavodoxin - COG4995 Uncharacterized protein conserved in bacteria 0.629424 ferredoxin - COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component 0.622416 ferredoxins - COG3937 Uncharacterized conserved protein 0.621260 biochemistry - COG2052 Uncharacterized protein conserved in bacteria 0.619732 ferredoxin - COG4242 Cyanophycinase and related exopeptidases 0.617568 chloroplast - COG2052 Uncharacterized protein conserved in bacteria 0.615746 spinach - COG3330 Uncharacterized protein conserved in bacteria 0.613775 glutamine - COG2052 Uncharacterized protein conserved in bacteria 0.610817 spinach - COG2052 Uncharacterized protein conserved in bacteria 0.607121 eubacteria - COG2385 Sporulation protein and related proteins 0.606042 glutamine - COG5401 Spore germination protein 0.602926 herbicide - COG5401 Spore germination protein 0.602277 ribulose - NOG12317 non supervised orthologous group 0.598618 ferredoxins - COG2385 Sporulation protein and related proteins 0.597577 flavodoxin - COG2385 Sporulation protein and related proteins 0.594021 eubacteria - COG3937 Uncharacterized conserved protein 0.590335 ferredoxins - COG3330 Uncharacterized protein conserved in bacteria 0.590329 ferredoxins - COG4242 Cyanophycinase and related exopeptidases 0.590258 ferredoxin - COG3330 Uncharacterized protein conserved in bacteria 0.588688 ribulose - COG3330 Uncharacterized protein conserved in bacteria 0.586325 herbicide - COG3330 Uncharacterized protein conserved in bacteria 0.585188 stabilization - COG2052 Uncharacterized protein conserved in bacteria 0.584165 acceptor - COG2052 Uncharacterized protein conserved in bacteria 0.583876 stabilization - COG5401 Spore germination protein 0.580768 barley - COG2385 Sporulation protein and related proteins 0.578762 glutamine - COG3330 Uncharacterized protein conserved in bacteria 0.578054 sulphur - COG2052 Uncharacterized protein conserved in bacteria 0.576423 biochemistry - COG5401 Spore germination protein 0.575443 ferredoxin - COG3937 Uncharacterized conserved protein 0.574860 ferredoxin - COG2389 Uncharacterized metal-binding protein 0.571876 ribulose - COG4995 Uncharacterized protein conserved in bacteria 0.571003 vinelandii - COG2052 Uncharacterized protein conserved in bacteria 0.569862 spinach - COG4242 Cyanophycinase and related exopeptidases 0.569154 ferredoxin - COG2385 Sporulation protein and related proteins 0.569059 barley - COG5401 Spore germination protein Cluster 9 ----------------------------------------------------------- 0.791836 lipooligosaccharide - COG3524 Capsule polysaccharide export protein 0.784464 lipooligosaccharide - COG3562 Capsule polysaccharide export protein 0.784464 lipooligosaccharide - COG3563 Capsule polysaccharide export protein 0.778143 lipooligosaccharide - COG2830 Uncharacterized protein conserved in bacteria 0.770996 lipooligosaccharides - COG3563 Capsule polysaccharide export protein 0.770996 lipooligosaccharides - COG3562 Capsule polysaccharide export protein 0.770055 lipooligosaccharides - COG3524 Capsule polysaccharide export protein 0.750062 postvaccination - COG3562 Capsule polysaccharide export protein 0.750062 postvaccination - COG3563 Capsule polysaccharide export protein 0.749473 postvaccination - COG2830 Uncharacterized protein conserved in bacteria 0.747886 postvaccination - COG3524 Capsule polysaccharide export protein 0.743431 multilocus - COG3779 Uncharacterized protein conserved in bacteria 0.742994 transferrin - COG2830 Uncharacterized protein conserved in bacteria 0.742421 lipooligosaccharides - COG2830 Uncharacterized protein conserved in bacteria 0.702567 multilocus - COG2852 Uncharacterized protein conserved in bacteria 0.684455 transferrin - COG3524 Capsule polysaccharide export protein 0.682913 multilocus - COG3563 Capsule polysaccharide export protein 0.682913 multilocus - COG3562 Capsule polysaccharide export protein 0.681863 multilocus - COG3524 Capsule polysaccharide export protein 0.680552 multilocus - COG2830 Uncharacterized protein conserved in bacteria 0.679436 transferrin - COG3563 Capsule polysaccharide export protein 0.679436 transferrin - COG3562 Capsule polysaccharide export protein 0.629219 meningitis - NOG14186 non supervised orthologous group 0.626075 lipooligosaccharides - COG3779 Uncharacterized protein conserved in bacteria 0.605198 household - COG2184 Protein involved in cell division 0.603481 tetanus - COG2830 Uncharacterized protein conserved in bacteria 0.597733 multilocus - COG4456 Virulence-associated protein and related proteins 0.597367 postvaccination - COG3421 Uncharacterized protein conserved in bacteria 0.591292 lipooligosaccharide - COG4737 Uncharacterized protein conserved in bacteria 0.586008 lipooligosaccharides - COG4737 Uncharacterized protein conserved in bacteria 0.580652 multilocus - NOG14186 non supervised orthologous group 0.576278 lipooligosaccharide - COG3779 Uncharacterized protein conserved in bacteria 0.574961 lipooligosaccharide - COG3421 Uncharacterized protein conserved in bacteria 0.569104 lipooligosaccharides - COG2852 Uncharacterized protein conserved in bacteria Cluster 10 ----------------------------------------------------------- 0.791393 xylanases - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.749683 xylanases - COG3860 Uncharacterized protein conserved in bacteria 0.748205 xylanase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.725479 xylanases - NOG12385 Putative oxidoreductase 0.723556 xylanases - NOG08018 non supervised orthologous group 0.701108 xylanase - NOG12385 Putative oxidoreductase 0.700743 xylanases - COG3940 Predicted beta-xylosidase 0.699381 xylanases - COG3861 Uncharacterized protein conserved in bacteria 0.682201 xylanase - COG3860 Uncharacterized protein conserved in bacteria 0.676457 germination - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.674197 subtilisin - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.667153 cellulase - NOG12385 Putative oxidoreductase 0.665857 subtilisin - NOG12385 Putative oxidoreductase 0.665505 xylanase - NOG08018 non supervised orthologous group 0.648585 xylanase - COG3940 Predicted beta-xylosidase 0.644944 xylanases - NOG09568 non supervised orthologous group 0.641117 germination - COG3940 Predicted beta-xylosidase 0.638847 germination - COG4187 Arginine degradation protein (predicted deacylase) 0.636902 xylanase - COG3861 Uncharacterized protein conserved in bacteria 0.632677 glucanase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.630061 cellulase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) 0.627014 germination - NOG08018 non supervised orthologous group 0.617653 xylanases - COG4247 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) 0.614847 xylanases - COG4294 UV damage repair endonuclease 0.608087 xylanases - NOG08287 non supervised orthologous group 0.603602 xylanases - COG3410 Uncharacterized conserved protein 0.599029 glucanase - COG4187 Arginine degradation protein (predicted deacylase) 0.598925 xylanases - NOG08290 non supervised orthologous group 0.592143 xylanase - COG4187 Arginine degradation protein (predicted deacylase) 0.588832 xylanase - COG4294 UV damage repair endonuclease 0.588105 xylanases - NOG14400 non supervised orthologous group 0.581233 thuringiensis - COG4187 Arginine degradation protein (predicted deacylase) 0.581095 xylanases - COG4187 Arginine degradation protein (predicted deacylase) 0.581092 germination - NOG12385 Putative oxidoreductase 0.578307 xylanase - NOG09568 non supervised orthologous group 0.577512 glucanase - NOG12385 Putative oxidoreductase 0.576404 endoglucanase - NOG12385 Putative oxidoreductase 0.575485 germination - COG3860 Uncharacterized protein conserved in bacteria 0.569428 xylanase - NOG08290 non supervised orthologous group 0.569353 malate - NOG08290 non supervised orthologous group Cluster 11 ----------------------------------------------------------- 0.784130 serotyping - COG3513 Uncharacterized protein conserved in bacteria 0.700978 serotyping - COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism 0.671199 serotyping - COG3512 Uncharacterized protein conserved in bacteria 0.627462 serotypes - COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism 0.610374 serotype - COG3513 Uncharacterized protein conserved in bacteria 0.591902 serotypes - COG3513 Uncharacterized protein conserved in bacteria 0.571098 serotype - COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Cluster 12 ----------------------------------------------------------- 0.780255 actinomyces - NOG06584 non supervised orthologous group 0.734848 bacteroides - NOG06584 non supervised orthologous group 0.712766 bacteroides - NOG14535 non supervised orthologous group 0.711788 peptostreptococcus - NOG06584 non supervised orthologous group 0.707167 anaerobe - NOG06584 non supervised orthologous group 0.705908 peptostreptococcus - NOG14535 non supervised orthologous group 0.679403 anaerobe - NOG14535 non supervised orthologous group 0.665685 fragilis - NOG06584 non supervised orthologous group 0.655424 actinomyces - COG3973 Superfamily I DNA and RNA helicases Cluster 13 ----------------------------------------------------------- 0.774752 stenotrophomonas - COG3746 Phosphate-selective porin 0.748624 maltophilia - COG3746 Phosphate-selective porin 0.727782 stenotrophomonas - COG3667 Uncharacterized protein involved in copper resistance 0.709809 enterobacter - COG4757 Predicted alpha/beta hydrolase 0.686891 stenotrophomonas - NOG08477 non supervised orthologous group 0.682895 stenotrophomonas - COG4287 PhoPQ-activated pathogenicity-related protein 0.675378 maltophilia - NOG08477 non supervised orthologous group 0.674233 maltophilia - COG4757 Predicted alpha/beta hydrolase 0.667151 stenotrophomonas - COG4229 Predicted enolase-phosphatase 0.665163 maltophilia - COG3667 Uncharacterized protein involved in copper resistance 0.660582 piperacillin - COG4757 Predicted alpha/beta hydrolase 0.660112 stenotrophomonas - COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain 0.653705 bacteriuria - COG4757 Predicted alpha/beta hydrolase 0.652375 exotoxin - COG4757 Predicted alpha/beta hydrolase 0.646927 stenotrophomonas - COG2941 Ubiquinone biosynthesis protein COQ7 0.644691 stenotrophomonas - COG3659 Carbohydrate-selective porin 0.641093 exopolysaccharide - COG3746 Phosphate-selective porin 0.631582 ceftazidime - COG4757 Predicted alpha/beta hydrolase 0.628161 maltophilia - COG3659 Carbohydrate-selective porin 0.627949 stenotrophomonas - COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases 0.627903 bacteriuria - COG0427 Acetyl-CoA hydrolase 0.624710 biofilms - COG4757 Predicted alpha/beta hydrolase 0.623158 proteus - COG4757 Predicted alpha/beta hydrolase 0.620640 stenotrophomonas - NOG08482 non supervised orthologous group 0.619865 pyelonephritis - COG4757 Predicted alpha/beta hydrolase 0.619091 maltophilia - COG4229 Predicted enolase-phosphatase 0.616073 acinetobacter - COG4757 Predicted alpha/beta hydrolase 0.614080 stenotrophomonas - NOG08527 non supervised orthologous group 0.611558 exotoxin - COG0427 Acetyl-CoA hydrolase 0.605258 acinetobacter - COG3667 Uncharacterized protein involved in copper resistance 0.604516 imipenem - COG4757 Predicted alpha/beta hydrolase 0.601942 maltophilia - COG2941 Ubiquinone biosynthesis protein COQ7 0.597920 maltophilia - NOG05493 non supervised orthologous group 0.595829 imipenem - NOG05493 non supervised orthologous group 0.578306 fibrosis - NOG28851 non supervised orthologous group 0.575562 neutropenia - COG4757 Predicted alpha/beta hydrolase 0.575025 cefoperazone - COG4757 Predicted alpha/beta hydrolase Cluster 14 ----------------------------------------------------------- 0.770556 proteasome - COG3462 Predicted membrane protein 0.762373 proteasome - COG3430 Uncharacterized protein conserved in archaea 0.762373 proteasome - COG3389 Uncharacterized protein conserved in archaea 0.750683 proteasome - COG3388 Uncharacterized protein conserved in archaea 0.704188 phospholipid - COG1910 Periplasmic molybdate-binding protein/domain 0.640056 phospholipid - COG1416 Uncharacterized conserved protein 0.596093 phospholipid - COG3462 Predicted membrane protein 0.582391 phospholipid - NOG09935 non supervised orthologous group 0.576059 megaterium - COG3377 Uncharacterized conserved protein Cluster 15 ----------------------------------------------------------- 0.765745 opsonization - COG3942 Surface antigen 0.723709 fibronectin - COG3942 Surface antigen 0.711766 physician - COG3942 Surface antigen 0.689384 institution - COG3942 Surface antigen 0.688291 empyema - COG3442 Predicted glutamine amidotransferase 0.666634 drainage - COG3442 Predicted glutamine amidotransferase 0.659323 empyema - COG3942 Surface antigen 0.654822 outpatient - COG3942 Surface antigen 0.654155 aspiration - COG3442 Predicted glutamine amidotransferase 0.645249 empyema - COG4720 Predicted membrane protein 0.637538 opsonization - COG4709 Predicted membrane protein 0.637388 drainage - COG3942 Surface antigen 0.637365 opsonization - NOG07968 non supervised orthologous group 0.637163 episode - COG3942 Surface antigen 0.636636 phagocytosis - COG4709 Predicted membrane protein 0.630511 debridement - COG4720 Predicted membrane protein 0.625535 debridement - COG3442 Predicted glutamine amidotransferase 0.622127 management - COG3942 Surface antigen 0.622123 drainage - COG4720 Predicted membrane protein 0.620626 abscess - COG3442 Predicted glutamine amidotransferase 0.617500 recurrence - COG3942 Surface antigen 0.617151 peritonitis - COG3942 Surface antigen 0.615779 effusion - COG3942 Surface antigen 0.612279 debridement - COG3942 Surface antigen 0.608624 fibronectin - NOG04835 non supervised orthologous group 0.603131 peritonitis - COG4720 Predicted membrane protein 0.601246 fibronectin - COG4709 Predicted membrane protein 0.591741 surveillance - COG3942 Surface antigen 0.582808 fibronectin - COG3442 Predicted glutamine amidotransferase 0.580143 hospitalization - COG3942 Surface antigen 0.579575 fibronectin - NOG07968 non supervised orthologous group 0.579375 emergency - COG3942 Surface antigen 0.575656 peritonitis - COG3442 Predicted glutamine amidotransferase 0.572788 phagocytosis - COG4716 Myosin-crossreactive antigen 0.569933 morbidity - COG3942 Surface antigen Cluster 16 ----------------------------------------------------------- 0.765387 glucanase - COG3507 Beta-xylosidase 0.751389 xylanases - COG3507 Beta-xylosidase 0.730662 xylanase - COG3507 Beta-xylosidase 0.701390 cellulase - COG3507 Beta-xylosidase 0.692393 amylase - COG3507 Beta-xylosidase 0.685545 subtilisin - COG3507 Beta-xylosidase 0.662833 methyltransferases - COG3507 Beta-xylosidase 0.662263 endoglucanase - COG3507 Beta-xylosidase 0.656849 xylanases - COG3866 Pectate lyase 0.653522 xylanases - NOG04140 non supervised orthologous group 0.646670 endoglucanase - COG2730 Endoglucanase 0.644322 xylanases - NOG04066 non supervised orthologous group 0.640868 germination - COG3507 Beta-xylosidase 0.633433 xylanase - COG3866 Pectate lyase 0.621441 glucanase - COG3858 Predicted glycosyl hydrolase 0.618049 glucanase - COG2730 Endoglucanase 0.614924 barley - COG2730 Endoglucanase 0.612788 xylanase - NOG04140 non supervised orthologous group 0.611949 glucanase - COG3661 Alpha-glucuronidase 0.611219 glucanase - COG3866 Pectate lyase 0.603519 xylanase - NOG04066 non supervised orthologous group 0.601758 xylanases - COG2730 Endoglucanase 0.599592 cellulase - NOG04140 non supervised orthologous group 0.591231 endoglucanase - COG1874 Beta-galactosidase 0.587747 erwinia - COG3661 Alpha-glucuronidase 0.586270 methyltransferase - COG3507 Beta-xylosidase 0.584398 cellulase - NOG04066 non supervised orthologous group 0.582779 erwinia - COG3858 Predicted glycosyl hydrolase 0.581027 cellulase - COG3866 Pectate lyase 0.575121 endoglucanase - COG3866 Pectate lyase 0.574831 thermophile - COG3858 Predicted glycosyl hydrolase 0.574812 endoglucanase - COG4555 ABC-type Na+ transport system, ATPase component 0.574417 cellulase - COG2730 Endoglucanase 0.574017 endoglucanase - NOG04140 non supervised orthologous group 0.573090 endoglucanase - NOG04066 non supervised orthologous group 0.571286 endoglucanase - COG3661 Alpha-glucuronidase 0.570742 starch - COG3507 Beta-xylosidase 0.570603 prolyl - COG3507 Beta-xylosidase Cluster 17 ----------------------------------------------------------- 0.764199 pseudotuberculosis - COG4924 Uncharacterized protein conserved in bacteria 0.729377 pseudotuberculosis - COG4913 Uncharacterized protein conserved in bacteria 0.633337 biovars - COG5373 Predicted membrane protein 0.631038 biovars - COG4963 Flp pilus assembly protein, ATPase CpaE 0.608304 rattus - COG4924 Uncharacterized protein conserved in bacteria 0.604303 biovars - COG4924 Uncharacterized protein conserved in bacteria 0.603198 rattus - COG3823 Glutamine cyclotransferase 0.596222 pseudotuberculosis - COG3823 Glutamine cyclotransferase 0.587289 rattus - COG4913 Uncharacterized protein conserved in bacteria 0.576669 pseudotuberculosis - COG3485 Protocatechuate 3,4-dioxygenase beta subunit 0.569914 biovars - COG4960 Flp pilus assembly protein, protease CpaA Cluster 18 ----------------------------------------------------------- 0.755607 artery - COG4284 UDP-glucose pyrophosphorylase 0.741989 bypass - COG4284 UDP-glucose pyrophosphorylase 0.726633 aneurysm - COG4284 UDP-glucose pyrophosphorylase 0.723057 artery - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.705191 aneurysm - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.699289 fibrinogen - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.688006 implantation - COG4284 UDP-glucose pyrophosphorylase 0.639072 aneurysm - COG2271 Sugar phosphate permease 0.630901 diabetes - COG1114 Branched-chain amino acid permeases 0.625221 artery - COG2271 Sugar phosphate permease 0.623414 surgery - COG1114 Branched-chain amino acid permeases 0.612415 fibrinogen - COG2271 Sugar phosphate permease 0.603447 bypass - NOG04823 putative hemaglutinin (prev. non supervised orthologous group) 0.598461 prosthesis - COG4284 UDP-glucose pyrophosphorylase 0.582497 artery - COG1114 Branched-chain amino acid permeases Cluster 19 ----------------------------------------------------------- 0.755410 viridans - COG3942 Surface antigen 0.737275 sanguis - COG3942 Surface antigen 0.708826 tonsillitis - COG3942 Surface antigen 0.673916 glomerulonephritis - COG3942 Surface antigen 0.665830 hypotension - COG3942 Surface antigen 0.649764 cefaclor - COG3942 Surface antigen 0.642042 prophylaxis - COG3942 Surface antigen 0.641146 cellulitis - COG3942 Surface antigen 0.627634 viridans - NOG07968 non supervised orthologous group 0.614817 coagulation - COG3942 Surface antigen 0.613172 cellulitis - COG4720 Predicted membrane protein 0.600936 pneumococcus - COG3942 Surface antigen 0.595586 otitis - COG3942 Surface antigen 0.579972 catarrhalis - COG3942 Surface antigen 0.579206 adherence - COG3942 Surface antigen 0.575151 carriage - COG3942 Surface antigen 0.568408 viridans - COG4709 Predicted membrane protein Cluster 20 ----------------------------------------------------------- 0.754351 catarrhalis - COG4300 Predicted permease, cadmium resistance protein 0.726584 purpura - COG4300 Predicted permease, cadmium resistance protein 0.716396 sanguis - COG4300 Predicted permease, cadmium resistance protein 0.707719 branhamella - COG4300 Predicted permease, cadmium resistance protein 0.707713 pneumococcus - COG4300 Predicted permease, cadmium resistance protein 0.700061 carriage - COG4300 Predicted permease, cadmium resistance protein 0.688057 cefaclor - COG4300 Predicted permease, cadmium resistance protein 0.680711 moraxella - COG4300 Predicted permease, cadmium resistance protein 0.676158 cellulitis - COG4300 Predicted permease, cadmium resistance protein 0.672629 purpura - COG2932 Predicted transcriptional regulator 0.670904 viridans - COG4300 Predicted permease, cadmium resistance protein 0.670164 pneumococcus - COG2932 Predicted transcriptional regulator 0.669491 otitis - COG4300 Predicted permease, cadmium resistance protein 0.665839 nasopharynx - COG4300 Predicted permease, cadmium resistance protein 0.662540 coagulation - COG4300 Predicted permease, cadmium resistance protein 0.660857 opsonin - COG2932 Predicted transcriptional regulator 0.642706 carriage - COG2855 Predicted membrane protein 0.641808 branhamella - COG2932 Predicted transcriptional regulator 0.640609 hypotension - COG4300 Predicted permease, cadmium resistance protein 0.637140 catarrhalis - COG2932 Predicted transcriptional regulator 0.634307 polysaccharide - COG2932 Predicted transcriptional regulator 0.630810 septicaemia - COG2855 Predicted membrane protein 0.630775 sinusitis - COG4300 Predicted permease, cadmium resistance protein 0.630296 opsonin - COG2855 Predicted membrane protein 0.621009 counterimmunoelectrophoresis - COG2932 Predicted transcriptional regulator 0.616780 cefotaxime - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.616406 bacteraemia - COG4300 Predicted permease, cadmium resistance protein 0.614512 nasopharynx - COG2932 Predicted transcriptional regulator 0.613373 septicaemia - COG4108 Peptide chain release factor RF-3 0.608071 tonsillitis - COG4300 Predicted permease, cadmium resistance protein 0.604843 sepsis - COG2855 Predicted membrane protein 0.604164 septicaemia - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.602287 prophylaxis - COG4300 Predicted permease, cadmium resistance protein 0.601013 branhamella - COG4108 Peptide chain release factor RF-3 0.600928 polysaccharide - COG4300 Predicted permease, cadmium resistance protein 0.599424 septicaemia - COG2606 Uncharacterized conserved protein 0.597931 carriage - COG2932 Predicted transcriptional regulator 0.596984 throat - COG4300 Predicted permease, cadmium resistance protein 0.595866 bacteraemia - COG2855 Predicted membrane protein 0.594314 sepsis - COG4300 Predicted permease, cadmium resistance protein 0.594129 school - COG4300 Predicted permease, cadmium resistance protein 0.593691 ceftriaxone - COG4108 Peptide chain release factor RF-3 0.591466 sulfamethoxazole - COG4108 Peptide chain release factor RF-3 0.591163 opsonin - COG4300 Predicted permease, cadmium resistance protein 0.590219 ceftriaxone - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.589304 cellulitis - COG2932 Predicted transcriptional regulator 0.587746 viridans - COG4108 Peptide chain release factor RF-3 0.578278 septicaemia - COG2932 Predicted transcriptional regulator 0.578236 hinton - COG4300 Predicted permease, cadmium resistance protein 0.578180 moraxella - COG2932 Predicted transcriptional regulator 0.577527 cefaclor - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.576577 opsonin - COG4108 Peptide chain release factor RF-3 0.574599 capsule - COG4300 Predicted permease, cadmium resistance protein 0.571772 counterimmunoelectrophoresis - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.571480 endophthalmitis - COG4108 Peptide chain release factor RF-3 0.571091 endophthalmitis - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.570514 cefotaxime - COG2855 Predicted membrane protein 0.570196 branhamella - COG2855 Predicted membrane protein 0.568660 sepsis - COG2932 Predicted transcriptional regulator 0.568514 infant - COG2932 Predicted transcriptional regulator Cluster 21 ----------------------------------------------------------- 0.754245 nodule - COG3701 Type IV secretory pathway, TrbF components 0.742810 nodule - COG5394 Uncharacterized protein conserved in bacteria Cluster 22 ----------------------------------------------------------- 0.752138 stomach - COG2604 Uncharacterized protein conserved in bacteria 0.698985 cytotoxin - COG2604 Uncharacterized protein conserved in bacteria 0.652438 stomach - COG2121 Uncharacterized protein conserved in bacteria 0.637590 stomach - COG2143 Thioredoxin-related protein 0.625975 diarrhea - COG1969 Ni,Fe-hydrogenase I cytochrome b subunit 0.625155 metronidazole - COG2604 Uncharacterized protein conserved in bacteria 0.621149 diarrhea - COG0298 Hydrogenase maturation factor 0.619152 diarrhea - COG0374 Ni,Fe-hydrogenase I large subunit 0.615315 diarrhoea - COG0309 Hydrogenase maturation factor 0.612730 colitis - COG0298 Hydrogenase maturation factor 0.611381 diarrhoea - COG0374 Ni,Fe-hydrogenase I large subunit 0.608859 diarrhoea - COG0298 Hydrogenase maturation factor 0.608201 colitis - COG0309 Hydrogenase maturation factor 0.603066 colitis - COG0680 Ni,Fe-hydrogenase maturation factor 0.601261 enteritis - COG0309 Hydrogenase maturation factor 0.599506 diarrhea - COG0680 Ni,Fe-hydrogenase maturation factor 0.598104 colitis - COG0374 Ni,Fe-hydrogenase I large subunit 0.597399 diarrhoea - COG1969 Ni,Fe-hydrogenase I cytochrome b subunit 0.595560 diarrhea - COG0309 Hydrogenase maturation factor 0.595145 colitis - COG0409 Hydrogenase maturation factor 0.595145 colitis - COG0068 Hydrogenase maturation factor 0.593763 diarrhea - COG0068 Hydrogenase maturation factor 0.593763 diarrhea - COG0409 Hydrogenase maturation factor 0.593746 cytotoxin - COG0309 Hydrogenase maturation factor 0.589433 diarrhoea - COG0680 Ni,Fe-hydrogenase maturation factor 0.588858 stomach - COG1969 Ni,Fe-hydrogenase I cytochrome b subunit 0.585974 enteritis - COG0298 Hydrogenase maturation factor 0.583031 diarrhoea - COG0068 Hydrogenase maturation factor 0.583031 diarrhoea - COG0409 Hydrogenase maturation factor 0.579992 enteritis - COG0374 Ni,Fe-hydrogenase I large subunit 0.579131 diarrhoea - COG1740 Ni,Fe-hydrogenase I small subunit 0.578198 cytotoxin - COG0680 Ni,Fe-hydrogenase maturation factor 0.577080 urease - COG1699 Uncharacterized protein conserved in bacteria 0.575686 cytotoxin - COG0374 Ni,Fe-hydrogenase I large subunit 0.573407 cytotoxin - COG1699 Uncharacterized protein conserved in bacteria 0.571836 diarrhea - COG1740 Ni,Fe-hydrogenase I small subunit 0.570188 cytotoxin - COG0068 Hydrogenase maturation factor 0.570188 cytotoxin - COG0409 Hydrogenase maturation factor 0.569654 cytotoxin - COG0298 Hydrogenase maturation factor Cluster 23 ----------------------------------------------------------- 0.750394 macrolides - NOG04835 non supervised orthologous group 0.691298 macrolide - NOG04835 non supervised orthologous group 0.656895 macrolides - COG2348 Uncharacterized protein involved in methicillin resistance 0.645351 macrolides - COG4485 Predicted membrane protein 0.611852 macrolide - COG2348 Uncharacterized protein involved in methicillin resistance 0.583626 azithromycin - NOG04835 non supervised orthologous group Cluster 24 ----------------------------------------------------------- 0.747610 glucosidase - COG2421 Predicted acetamidase/formamidase 0.705613 holliday - COG2421 Predicted acetamidase/formamidase 0.659496 aminotransferase - COG2421 Predicted acetamidase/formamidase 0.643454 cellobiose - COG2421 Predicted acetamidase/formamidase 0.626180 polymerases - COG2421 Predicted acetamidase/formamidase 0.626064 thermophilus - COG2421 Predicted acetamidase/formamidase 0.606490 thermostability - COG2421 Predicted acetamidase/formamidase 0.598773 archaeon - COG2421 Predicted acetamidase/formamidase 0.580968 nitrophenyl - COG2421 Predicted acetamidase/formamidase 0.573227 thermus - COG2421 Predicted acetamidase/formamidase 0.572977 maltose - COG2421 Predicted acetamidase/formamidase 0.569633 cellobiose - COG3595 Uncharacterized conserved protein Cluster 25 ----------------------------------------------------------- 0.746693 alginate - COG4757 Predicted alpha/beta hydrolase 0.671982 biodegradation - COG4757 Predicted alpha/beta hydrolase 0.658372 toluene - COG4757 Predicted alpha/beta hydrolase 0.646619 alcaligenes - COG4757 Predicted alpha/beta hydrolase 0.625352 dioxygenase - COG4757 Predicted alpha/beta hydrolase 0.618374 biodegradation - COG3332 Uncharacterized conserved protein 0.614717 dioxygenase - COG3332 Uncharacterized conserved protein 0.610755 toluene - COG3332 Uncharacterized conserved protein 0.608085 alginate - COG3332 Uncharacterized conserved protein 0.594634 periplasm - COG0427 Acetyl-CoA hydrolase 0.589962 fluorescens - COG4757 Predicted alpha/beta hydrolase 0.587818 biodegradation - COG3659 Carbohydrate-selective porin 0.580427 alginate - COG3667 Uncharacterized protein involved in copper resistance 0.580038 alginate - NOG08482 non supervised orthologous group 0.574689 catechol - COG4757 Predicted alpha/beta hydrolase 0.571143 homoserine - COG0427 Acetyl-CoA hydrolase 0.569181 alginate - COG3659 Carbohydrate-selective porin 0.568219 toluene - NOG08482 non supervised orthologous group Cluster 26 ----------------------------------------------------------- 0.744047 hinton - COG1636 Uncharacterized protein conserved in bacteria 0.738020 purpura - COG1636 Uncharacterized protein conserved in bacteria 0.718315 colonisation - COG1636 Uncharacterized protein conserved in bacteria 0.717764 mueller - COG1636 Uncharacterized protein conserved in bacteria 0.701511 carriage - COG1636 Uncharacterized protein conserved in bacteria 0.688147 bacteraemia - COG1636 Uncharacterized protein conserved in bacteria 0.669094 prophylaxis - COG1636 Uncharacterized protein conserved in bacteria 0.636448 coagulation - COG1636 Uncharacterized protein conserved in bacteria 0.619461 cellulitis - COG1636 Uncharacterized protein conserved in bacteria 0.589542 adherence - COG1636 Uncharacterized protein conserved in bacteria 0.580665 opsonin - COG1636 Uncharacterized protein conserved in bacteria 0.578838 purpura - COG0738 Fucose permease 0.573833 sepsis - COG1636 Uncharacterized protein conserved in bacteria 0.573298 mucosa - COG1636 Uncharacterized protein conserved in bacteria 0.569720 cefaclor - COG1636 Uncharacterized protein conserved in bacteria Cluster 27 ----------------------------------------------------------- 0.737912 pseudotuberculosis - COG4331 Predicted membrane protein 0.730738 rattus - COG4331 Predicted membrane protein 0.723828 rattus - NOG08582 non supervised orthologous group 0.692379 rattus - NOG09834 non supervised orthologous group 0.687545 biovars - COG3892 Uncharacterized protein conserved in bacteria 0.676978 biovars - COG4331 Predicted membrane protein 0.676453 biovars - COG3683 ABC-type uncharacterized transport system, periplasmic component 0.657839 rodent - NOG08582 non supervised orthologous group 0.641323 pseudotuberculosis - NOG08582 non supervised orthologous group 0.639245 rattus - NOG06493 non supervised orthologous group 0.595942 biovars - NOG08582 non supervised orthologous group 0.590672 pseudotuberculosis - NOG06493 non supervised orthologous group 0.590049 biovars - NOG09458 non supervised orthologous group 0.584421 biovars - COG3963 Phospholipid N-methyltransferase 0.570339 biovars - COG4099 Predicted peptidase Cluster 28 ----------------------------------------------------------- 0.737697 symbiont - COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) 0.727340 planta - COG5394 Uncharacterized protein conserved in bacteria 0.716925 symbiont - COG4227 Antirestriction protein 0.694614 symbiont - COG3701 Type IV secretory pathway, TrbF components 0.688363 planta - COG5267 Uncharacterized protein conserved in bacteria 0.688363 planta - COG4102 Uncharacterized protein conserved in bacteria 0.686479 rhizobium - COG5394 Uncharacterized protein conserved in bacteria 0.683359 symbiont - COG5394 Uncharacterized protein conserved in bacteria 0.677292 symbiont - COG1509 Lysine 2,3-aminomutase 0.675906 nitrogenase - COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain 0.670959 rhizobium - COG4553 Poly-beta-hydroxyalkanoate depolymerase (probably not required for symbiosis, but it has been proposed to be essential for the non-symbiotic state of Rhizobia (LARA L. MADISON AND GJALT W. HUISMAN, 1999) -> might thus be essential for re-infection... Moreover, a might turn off the PHA system for symbiosis, since it depolymerises the carbon storage molecule PHA 0.665448 rhizobium - COG3701 Type IV secretory pathway, TrbF components 0.655374 rhizobium - COG3838 Type IV secretory pathway, VirB2 components (pilins) 0.649336 planta - COG3828 Uncharacterized protein conserved in bacteria 0.636380 glucans - COG1509 Lysine 2,3-aminomutase 0.622058 rhizobium - COG4102 Uncharacterized protein conserved in bacteria 0.622058 rhizobium - COG5267 Uncharacterized protein conserved in bacteria 0.614303 planta - COG4553 Poly-beta-hydroxyalkanoate depolymerase (probably not required for symbiosis, but it has been proposed to be essential for the non-symbiotic state of Rhizobia (LARA L. MADISON AND GJALT W. HUISMAN, 1999) -> might thus be essential for re-infection... Moreover, a might turn off the PHA system for symbiosis, since it depolymerises the carbon storage molecule PHA 0.612443 glucuronidase - COG4227 Antirestriction protein 0.611145 seedling - COG3828 Uncharacterized protein conserved in bacteria 0.604779 glucans - COG1794 Aspartate racemase 0.602066 alfalfa - COG4227 Antirestriction protein 0.600321 seedling - COG5394 Uncharacterized protein conserved in bacteria 0.597937 rhizobium - COG4227 Antirestriction protein 0.593097 nitrogen - COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain 0.583938 glucans - COG5394 Uncharacterized protein conserved in bacteria 0.576014 rhizobium - COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain 0.570215 glucans - COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Cluster 29 ----------------------------------------------------------- 0.737570 haemin - COG4393 Predicted membrane protein 0.670265 haemin - COG4331 Predicted membrane protein 0.655972 haemin - COG3350 Uncharacterized conserved protein 0.635986 haemin - NOG08582 non supervised orthologous group 0.634426 capsular - COG4393 Predicted membrane protein 0.627101 capsular - COG3683 ABC-type uncharacterized transport system, periplasmic component 0.606755 capsule - COG4393 Predicted membrane protein 0.603790 haemin - NOG09834 non supervised orthologous group 0.596630 capsular - COG4331 Predicted membrane protein 0.592693 haemin - COG3683 ABC-type uncharacterized transport system, periplasmic component 0.590532 capsular - COG4099 Predicted peptidase 0.585008 haemin - COG4099 Predicted peptidase 0.574279 haemin - NOG06493 non supervised orthologous group 0.569757 capsular - NOG08582 non supervised orthologous group Cluster 30 ----------------------------------------------------------- 0.735936 catechol - COG4323 Predicted membrane protein 0.672689 catechol - COG3258 Cytochrome c 0.654682 toluene - COG4323 Predicted membrane protein 0.653326 catechol - NOG16120 non supervised orthologous group 0.646401 catechol - NOG29369 non supervised orthologous group 0.646373 catechol - COG4324 Predicted aminopeptidase 0.643099 catechol - COG4254 Uncharacterized protein conserved in bacteria 0.629074 catechol - COG3650 Predicted membrane protein 0.628848 catechol - NOG09828 non supervised orthologous group 0.628848 catechol - NOG18807 non supervised orthologous group 0.607446 toluene - COG4324 Predicted aminopeptidase 0.602275 dioxygenase - COG4323 Predicted membrane protein 0.601159 catechol - COG5018 Inhibitor of the KinA pathway to sporulation, predicted exonuclease 0.593584 catechol - NOG09857 non supervised orthologous group 0.593198 dioxygenase - COG3258 Cytochrome c 0.585071 catechol - COG3644 Uncharacterized protein conserved in bacteria 0.582498 toluene - NOG16120 non supervised orthologous group 0.570499 dioxygenase - COG3917 2-hydroxychromene-2-carboxylate isomerase 0.569413 dioxygenase - NOG09274 non supervised orthologous group 0.568631 toluene - COG3258 Cytochrome c 0.568452 catechol - COG3825 Uncharacterized protein conserved in bacteria Cluster 31 ----------------------------------------------------------- 0.733275 haemolyticus - COG4721 Predicted membrane protein 0.718885 catheter - COG4721 Predicted membrane protein 0.670326 cefazolin - COG4721 Predicted membrane protein 0.647033 surgery - COG2035 Predicted membrane protein 0.640177 oxacillin - COG4721 Predicted membrane protein 0.635937 vancomycin - COG4721 Predicted membrane protein 0.622017 coagulase - COG4721 Predicted membrane protein 0.609514 exotoxin - COG2035 Predicted membrane protein 0.608531 teicoplanin - COG4721 Predicted membrane protein 0.607214 endocarditis - COG4721 Predicted membrane protein 0.605567 cefazolin - COG2035 Predicted membrane protein 0.604149 vancomycin - COG2035 Predicted membrane protein 0.599590 haemolyticus - COG2035 Predicted membrane protein 0.588094 lactation - COG4721 Predicted membrane protein 0.579307 vancomycin - COG3764 Sortase (surface protein transpeptidase) 0.573799 teicoplanin - COG2035 Predicted membrane protein 0.572784 catheter - COG2035 Predicted membrane protein Cluster 32 ----------------------------------------------------------- 0.732770 gangrene - NOG18091 probably polysaccharid/capsule biosynthesis (prev. non supervised orthologous group) 0.717017 gangrene - NOG09246 non supervised orthologous group 0.688539 gangrene - COG1243 Histone acetyltransferase 0.676275 gangrene - COG3862 Uncharacterized protein with conserved CXXC pairs 0.670852 gangrene - NOG28580 non supervised orthologous group 0.665104 gangrene - COG3968 Uncharacterized protein related to glutamine synthetase 0.652179 anaerobe - COG3875 Uncharacterized conserved protein 0.649165 anaerobe - COG3877 Uncharacterized protein conserved in bacteria 0.646269 fragilis - NOG09246 non supervised orthologous group 0.644979 anaerobe - COG3862 Uncharacterized protein with conserved CXXC pairs 0.640873 bacteroides - COG3877 Uncharacterized protein conserved in bacteria 0.632199 anaerobe - NOG28580 non supervised orthologous group 0.630762 fragilis - COG1243 Histone acetyltransferase 0.627175 peptostreptococcus - COG3877 Uncharacterized protein conserved in bacteria 0.626235 bacteroides - NOG28580 non supervised orthologous group 0.618156 bacteroides - COG3862 Uncharacterized protein with conserved CXXC pairs 0.615897 bacteroides - NOG09246 non supervised orthologous group 0.610595 anaerobe - COG2768 Uncharacterized Fe-S center protein 0.608609 anaerobe - COG1243 Histone acetyltransferase 0.606628 fragilis - COG3862 Uncharacterized protein with conserved CXXC pairs 0.604040 fragilis - NOG28580 non supervised orthologous group 0.602534 anaerobe - COG2316 Predicted hydrolase (HD superfamily) 0.600187 peptostreptococcus - COG3862 Uncharacterized protein with conserved CXXC pairs 0.599621 peptostreptococcus - NOG28580 non supervised orthologous group 0.575515 peptostreptococcus - COG3968 Uncharacterized protein related to glutamine synthetase Cluster 33 ----------------------------------------------------------- 0.732521 germination - COG3584 Uncharacterized protein conserved in bacteria 0.689480 germination - COG3426 Butyrate kinase 0.660571 germination - COG1811 Uncharacterized membrane protein, possible Na+ channel or pump 0.647179 germination - COG3872 Predicted metal-dependent enzyme 0.639343 denitrificans - COG4194 Predicted membrane protein 0.625225 cellobiose - COG3584 Uncharacterized protein conserved in bacteria 0.624935 cellobiose - COG3426 Butyrate kinase 0.622443 germination - COG1480 Predicted membrane-associated HD superfamily hydrolase 0.620288 starch - COG3584 Uncharacterized protein conserved in bacteria 0.610688 sorbitol - COG1811 Uncharacterized membrane protein, possible Na+ channel or pump 0.596650 germination - COG1550 Uncharacterized protein conserved in bacteria 0.595282 barley - COG3584 Uncharacterized protein conserved in bacteria 0.575795 barley - COG1480 Predicted membrane-associated HD superfamily hydrolase 0.574733 thermophile - COG3584 Uncharacterized protein conserved in bacteria 0.574163 cellobiose - COG3872 Predicted metal-dependent enzyme 0.572800 denitrificans - COG3933 Transcriptional antiterminator 0.572088 starch - COG3426 Butyrate kinase 0.569930 starch - COG3872 Predicted metal-dependent enzyme 0.569316 barley - COG3426 Butyrate kinase Cluster 34 ----------------------------------------------------------- 0.731631 haemin - COG3657 Uncharacterized protein conserved in bacteria 0.701573 capsular - COG3657 Uncharacterized protein conserved in bacteria 0.676039 capsular - COG3636 Predicted transcriptional regulator 0.672891 haemin - COG3636 Predicted transcriptional regulator 0.595691 haemin - COG4924 Uncharacterized protein conserved in bacteria 0.580061 capsular - COG4960 Flp pilus assembly protein, protease CpaA 0.575281 capsule - COG3636 Predicted transcriptional regulator 0.573889 haemin - COG4913 Uncharacterized protein conserved in bacteria 0.569797 capsule - COG3657 Uncharacterized protein conserved in bacteria Cluster 35 ----------------------------------------------------------- 0.726623 intoxication - COG4413 Urea transporter Cluster 36 ----------------------------------------------------------- 0.725096 antitoxin - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.684143 toxigenic - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.618205 intestine - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.598902 diarrhoea - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.584941 enteritis - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.574860 piglet - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily Cluster 37 ----------------------------------------------------------- 0.723254 thymine - COG1904 Glucuronate isomerase 0.668618 glucanase - COG1904 Glucuronate isomerase 0.653303 polyda - COG1904 Glucuronate isomerase 0.651300 stearothermophilus - COG1904 Glucuronate isomerase 0.649820 minicells - COG1904 Glucuronate isomerase 0.646893 endoglucanase - COG1904 Glucuronate isomerase 0.640597 minicells - COG2311 Predicted membrane protein 0.631123 seedling - COG3766 Predicted membrane protein 0.630279 periplasm - COG1904 Glucuronate isomerase 0.626659 glucanase - COG2311 Predicted membrane protein 0.608915 terminator - COG2311 Predicted membrane protein 0.601190 kilobase - COG1904 Glucuronate isomerase 0.598242 stearothermophilus - COG2311 Predicted membrane protein 0.597749 amylase - COG1904 Glucuronate isomerase 0.596960 xylanase - COG1904 Glucuronate isomerase 0.594720 permease - COG1904 Glucuronate isomerase 0.593694 guanine - COG1904 Glucuronate isomerase 0.593385 cellulase - COG1904 Glucuronate isomerase 0.588051 tetramer - COG1904 Glucuronate isomerase 0.587411 glucanase - COG3546 Mn-containing catalase 0.587089 erwinia - COG3546 Mn-containing catalase 0.583283 erwinia - COG2311 Predicted membrane protein 0.581675 glucanase - COG4260 Putative virion core protein (lumpy skin disease virus) 0.579726 barley - COG1904 Glucuronate isomerase 0.577844 melting - COG1904 Glucuronate isomerase 0.575213 thermophile - COG1904 Glucuronate isomerase 0.570538 germination - COG3546 Mn-containing catalase Cluster 38 ----------------------------------------------------------- 0.722498 glycosyltransferase - COG2364 Predicted membrane protein 0.665098 glycosyltransferase - NOG07232 non supervised orthologous group Cluster 39 ----------------------------------------------------------- 0.715739 poisoning - COG1922 Teichoic acid biosynthesis proteins 0.673849 poisoning - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.667233 poisoning - COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 0.653543 poisoning - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.645167 poisoning - COG2738 Predicted Zn-dependent protease 0.631610 enterocolitis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.594494 poisoning - COG3870 Uncharacterized protein conserved in bacteria 0.592138 poisoning - COG1774 Uncharacterized homolog of PSP1 Cluster 40 ----------------------------------------------------------- 0.715482 rhamnose - COG4443 Uncharacterized protein conserved in bacteria 0.673010 rhamnose - COG4687 Uncharacterized protein conserved in bacteria 0.663254 rhamnose - COG3579 Aminopeptidase C 0.652661 rhamnose - COG4708 Predicted membrane protein 0.642243 rhamnose - NOG09371 non supervised orthologous group 0.621379 rhamnose - COG3538 uncharacterized, freuqently in operons with sugar/polysaccharide-related proteins [rhamnose could be promising, in cell wall of some Gram- and Gram+ bacteria] (prev. Uncharacterized conserved protein) 0.586403 rhamnose - COG3883 Uncharacterized protein conserved in bacteria 0.585297 rhamnose - COG2315 Uncharacterized protein conserved in bacteria 0.582765 rhamnose - COG3859 Predicted membrane protein Cluster 41 ----------------------------------------------------------- 0.714146 gerbil - COG4393 Predicted membrane protein 0.697838 gerbil - COG4331 Predicted membrane protein 0.696621 gerbil - COG4268 McrBC 5-methylcytosine restriction system component 0.687429 gerbil - COG3350 Uncharacterized conserved protein 0.667650 gerbil - NOG08582 non supervised orthologous group 0.635520 gerbil - COG4099 Predicted peptidase 0.623274 gerbil - COG3345 Alpha-galactosidase 0.622237 gerbil - COG3867 Arabinogalactan endo-1,4-beta-galactosidase 0.611013 gerbil - NOG09834 non supervised orthologous group 0.595514 gerbil - COG1401 GTPase subunit of restriction endonuclease 0.588874 gerbil - COG5276 Uncharacterized conserved protein 0.587793 gerbil - NOG06493 non supervised orthologous group Cluster 42 ----------------------------------------------------------- 0.713492 actinomyces - NOG27896 non supervised orthologous group 0.702260 actinomyces - COG3864 Uncharacterized protein conserved in bacteria 0.678665 actinomyces - NOG10337 non supervised orthologous group 0.638173 actinomyces - COG3861 Uncharacterized protein conserved in bacteria 0.637884 actinomyces - NOG09952 non supervised orthologous group 0.630020 actinomyces - NOG08919 non supervised orthologous group 0.608222 tylosin - COG4295 Uncharacterized protein conserved in bacteria 0.604276 actinomyces - NOG09703 non supervised orthologous group 0.603205 actinomyces - COG4295 Uncharacterized protein conserved in bacteria 0.601372 actinomyces - COG4320 Uncharacterized protein conserved in bacteria 0.592282 actinomyces - NOG11829 non supervised orthologous group 0.576441 actinomyces - NOG19949 non supervised orthologous group Cluster 43 ----------------------------------------------------------- 0.713437 multilocus - COG4797 Predicted regulatory domain of a methyltransferase 0.674737 lipooligosaccharide - COG4797 Predicted regulatory domain of a methyltransferase 0.660058 lipooligosaccharide - COG3453 Uncharacterized protein conserved in bacteria 0.656600 lipooligosaccharides - COG4797 Predicted regulatory domain of a methyltransferase 0.652799 toxoid - COG4942 Membrane-bound metallopeptidase 0.652750 postvaccination - COG3453 Uncharacterized protein conserved in bacteria 0.648384 postvaccination - COG4797 Predicted regulatory domain of a methyltransferase 0.643614 lipooligosaccharides - COG3514 Uncharacterized protein conserved in bacteria 0.640956 transferrin - COG4797 Predicted regulatory domain of a methyltransferase 0.639007 vaccinees - COG2913 Small protein A (tmRNA-binding) 0.627999 postvaccination - COG2840 Uncharacterized protein conserved in bacteria 0.626235 lipooligosaccharides - COG3453 Uncharacterized protein conserved in bacteria 0.621040 vaccinees - COG2840 Uncharacterized protein conserved in bacteria 0.618093 vaccinees - COG1952 Preprotein translocase subunit SecB 0.616046 meningitis - COG4797 Predicted regulatory domain of a methyltransferase 0.601485 lipooligosaccharide - COG3468 Type V secretory pathway, adhesin AidA 0.598689 vaccinees - COG2917 Intracellular septation protein A 0.593966 lipooligosaccharides - COG3468 Type V secretory pathway, adhesin AidA 0.592919 postvaccination - COG3468 Type V secretory pathway, adhesin AidA 0.592649 postvaccination - COG2833 Uncharacterized protein conserved in bacteria 0.590591 lipooligosaccharide - COG3514 Uncharacterized protein conserved in bacteria 0.587538 lipooligosaccharide - COG2833 Uncharacterized protein conserved in bacteria 0.587232 vaccinees - COG3514 Uncharacterized protein conserved in bacteria 0.582960 vaccinees - COG2961 Protein involved in catabolism of external DNA 0.582412 meningitis - COG1952 Preprotein translocase subunit SecB 0.578783 lipooligosaccharide - COG2845 Uncharacterized protein conserved in bacteria 0.578718 meningitis - COG2913 Small protein A (tmRNA-binding) 0.576291 vaccinees - COG2927 DNA polymerase III, chi subunit 0.571584 vaccinees - COG0729 Outer membrane protein 0.571056 tetanus - COG4942 Membrane-bound metallopeptidase Cluster 44 ----------------------------------------------------------- 0.713295 vancomycin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.679835 imipenem - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.618675 enterobacter - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.617539 proteus - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.615635 oxacillin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.609036 piperacillin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.573066 exotoxin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 45 ----------------------------------------------------------- 0.711399 multilocus - COG3567 Uncharacterized protein conserved in bacteria 0.711399 multilocus - COG3566 Uncharacterized protein conserved in bacteria 0.629128 memory - COG3567 Uncharacterized protein conserved in bacteria 0.629128 memory - COG3566 Uncharacterized protein conserved in bacteria Cluster 46 ----------------------------------------------------------- 0.709514 multilocus - COG3759 Predicted membrane protein Cluster 47 ----------------------------------------------------------- 0.705840 lecithinase - COG3878 Uncharacterized protein conserved in bacteria 0.699507 lecithinase - COG2738 Predicted Zn-dependent protease 0.695397 lecithinase - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.662403 lecithinase - COG1774 Uncharacterized homolog of PSP1 0.657575 carcass - COG1922 Teichoic acid biosynthesis proteins 0.656586 cereus - COG2340 Uncharacterized protein with SCP/PR1 domains 0.651415 sausage - COG3878 Uncharacterized protein conserved in bacteria 0.650120 cereus - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.649443 lecithinase - COG3870 Uncharacterized protein conserved in bacteria 0.634048 lecithinase - COG2340 Uncharacterized protein with SCP/PR1 domains 0.628419 sausage - COG0615 Cytidylyltransferase 0.625145 cereus - COG3870 Uncharacterized protein conserved in bacteria 0.620724 cereus - COG2738 Predicted Zn-dependent protease 0.610579 starter - COG3878 Uncharacterized protein conserved in bacteria 0.610262 spoilage - COG2738 Predicted Zn-dependent protease 0.609172 sausage - COG3855 Uncharacterized protein conserved in bacteria 0.607602 cereus - COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 0.590121 cereus - COG4496 Uncharacterized protein conserved in bacteria 0.587588 spoilage - COG2088 Uncharacterized protein, involved in the regulation of septum location 0.583642 lecithinase - COG3855 Uncharacterized protein conserved in bacteria 0.583592 spoilage - COG1922 Teichoic acid biosynthesis proteins 0.582590 spoilage - COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 0.578250 lecithinase - COG4956 Integral membrane protein (PIN domain superfamily) 0.575877 spoilage - COG1774 Uncharacterized homolog of PSP1 0.573980 poultry - COG3878 Uncharacterized protein conserved in bacteria 0.572530 cereus - COG1774 Uncharacterized homolog of PSP1 0.572078 lecithinase - COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 0.570448 spoilage - COG4496 Uncharacterized protein conserved in bacteria Cluster 48 ----------------------------------------------------------- 0.705357 megaterium - COG2720 Uncharacterized vancomycin resistance protein Cluster 49 ----------------------------------------------------------- 0.705294 gangrene - COG3404 Methenyl tetrahydrofolate cyclohydrolase Cluster 50 ----------------------------------------------------------- 0.705188 management - COG1636 Uncharacterized protein conserved in bacteria 0.700766 recurrence - COG1636 Uncharacterized protein conserved in bacteria 0.670790 institution - COG1636 Uncharacterized protein conserved in bacteria 0.667576 childhood - COG1636 Uncharacterized protein conserved in bacteria 0.642156 emergency - COG1636 Uncharacterized protein conserved in bacteria 0.637138 susceptibility - COG1636 Uncharacterized protein conserved in bacteria 0.625937 admission - COG1636 Uncharacterized protein conserved in bacteria 0.625532 peritonitis - COG1636 Uncharacterized protein conserved in bacteria 0.607734 epidemiology - COG1636 Uncharacterized protein conserved in bacteria 0.602284 morbidity - COG1636 Uncharacterized protein conserved in bacteria 0.600411 syndrome - COG1636 Uncharacterized protein conserved in bacteria 0.600107 complication - COG1636 Uncharacterized protein conserved in bacteria 0.599877 surveillance - COG1636 Uncharacterized protein conserved in bacteria 0.595534 outcome - COG1636 Uncharacterized protein conserved in bacteria 0.594608 episode - COG1636 Uncharacterized protein conserved in bacteria 0.583193 hospital - COG1636 Uncharacterized protein conserved in bacteria 0.579962 hospitalization - COG1636 Uncharacterized protein conserved in bacteria 0.579106 drainage - COG1636 Uncharacterized protein conserved in bacteria 0.571519 arthritis - COG1636 Uncharacterized protein conserved in bacteria Cluster 51 ----------------------------------------------------------- 0.704855 maltophilia - COG4290 Guanyl-specific ribonuclease Sa 0.663037 maltophilia - NOG05512 non supervised orthologous group 0.623070 vancomycin - NOG14203 non supervised orthologous group 0.618732 bacteriuria - NOG14203 non supervised orthologous group 0.615922 stenotrophomonas - NOG05512 non supervised orthologous group 0.615907 neutropenia - NOG14203 non supervised orthologous group 0.613027 stenotrophomonas - COG4290 Guanyl-specific ribonuclease Sa 0.594113 maltophilia - COG4805 Uncharacterized protein conserved in bacteria 0.580642 teicoplanin - NOG14203 non supervised orthologous group 0.573341 cefazolin - NOG14203 non supervised orthologous group 0.569681 ointment - NOG14203 non supervised orthologous group Cluster 52 ----------------------------------------------------------- 0.701118 haemin - COG4929 Uncharacterized membrane-anchored protein 0.650386 trimethoprim - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase 0.634237 haemin - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.611937 sulfamethoxazole - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase 0.572534 haemin - COG3822 ABC-type sugar transport system, auxiliary component Cluster 53 ----------------------------------------------------------- 0.700558 healing - NOG06005 non supervised orthologous group 0.682259 silicone - NOG06005 non supervised orthologous group 0.678158 silicone - NOG14978 non supervised orthologous group 0.663579 healing - COG3886 Predicted HKD family nuclease 0.662391 implant - NOG14978 non supervised orthologous group 0.633486 prosthesis - NOG14978 non supervised orthologous group 0.596089 device - NOG06005 non supervised orthologous group 0.591700 implantation - NOG14978 non supervised orthologous group 0.585362 cornea - NOG06005 non supervised orthologous group Cluster 54 ----------------------------------------------------------- 0.700105 archaea - COG1865 Uncharacterized conserved protein 0.698335 thermostability - COG1865 Uncharacterized conserved protein 0.688128 archaeon - COG1361 S-layer domain 0.675950 diffraction - COG1865 Uncharacterized conserved protein 0.672242 archaea - COG1361 S-layer domain 0.669554 crystallization - COG1865 Uncharacterized conserved protein 0.655357 archaebacterium - COG3374 Predicted membrane protein 0.654629 archaeon - COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 0.652815 archaeon - COG2512 Uncharacterized membrane-associated protein/domain 0.645769 archaebacterium - COG3370 Uncharacterized protein conserved in archaea 0.643815 archaebacteria - COG3413 Predicted DNA binding protein 0.642536 archaeon - COG2237 Predicted membrane protein 0.637698 ferredoxin - COG1449 Alpha-amylase/alpha-mannosidase 0.634165 archaeon - COG1865 Uncharacterized conserved protein 0.627871 archaea - COG2237 Predicted membrane protein 0.626349 archaebacterium - COG3413 Predicted DNA binding protein 0.626341 archaeon - COG2412 Uncharacterized conserved protein 0.624537 archaebacteria - COG1865 Uncharacterized conserved protein 0.622327 archaebacteria - COG3370 Uncharacterized protein conserved in archaea 0.621726 acidocaldarius - COG3374 Predicted membrane protein 0.619817 archaebacterium - COG3432 Predicted transcriptional regulator 0.619745 archaeon - COG1681 Archaeal flagellins 0.619745 archaeon - COG2874 Predicted ATPases involved in biogenesis of archaeal flagella 0.619745 archaeon - COG1955 Archaeal flagella assembly protein J 0.618446 archaebacteria - COG3374 Predicted membrane protein 0.616560 acidocaldarius - COG3370 Uncharacterized protein conserved in archaea 0.615108 archaea - COG2412 Uncharacterized conserved protein 0.615051 archaea - COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 0.613745 archaea - COG2512 Uncharacterized membrane-associated protein/domain 0.612727 archaeon - COG1709 Predicted transcriptional regulator 0.612669 archaeon - COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) 0.609908 archaea - COG1102 Cytidylate kinase 0.609165 acidocaldarius - COG4847 Uncharacterized protein conserved in archaea 0.608056 archaea - COG1955 Archaeal flagella assembly protein J 0.608056 archaea - COG1681 Archaeal flagellins 0.608056 archaea - COG2874 Predicted ATPases involved in biogenesis of archaeal flagella 0.606661 archaea - COG1709 Predicted transcriptional regulator 0.606609 crystal - COG1865 Uncharacterized conserved protein 0.606304 archaeon - COG1449 Alpha-amylase/alpha-mannosidase 0.603057 archaeon - COG1602 Uncharacterized conserved protein 0.602223 archaebacteria - COG3432 Predicted transcriptional regulator 0.600120 archaeon - COG3372 Uncharacterized conserved protein 0.599674 archaea - COG1602 Uncharacterized conserved protein 0.598206 archaebacterium - COG1361 S-layer domain 0.596507 archaea - COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) 0.595678 archaebacteria - COG1340 Uncharacterized archaeal coiled-coil protein 0.595482 ferredoxins - COG1449 Alpha-amylase/alpha-mannosidase 0.595249 acidocaldarius - COG3413 Predicted DNA binding protein 0.594967 archaebacterium - COG1340 Uncharacterized archaeal coiled-coil protein 0.594314 archaeon - COG2123 RNase PH-related exoribonuclease 0.594314 archaeon - COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) 0.593984 archaebacterium - COG4986 ABC-type anion transport system, duplicated permease component 0.592369 archaeon - COG1474 Cdc6-related protein, AAA superfamily ATPase 0.587802 archaebacterium - COG4847 Uncharacterized protein conserved in archaea 0.584864 archaebacterium - COG1602 Uncharacterized conserved protein 0.584000 archaea - COG3372 Uncharacterized conserved protein 0.582741 archaebacterium - COG2237 Predicted membrane protein 0.582482 archaebacteria - COG4986 ABC-type anion transport system, duplicated permease component 0.579734 archaebacterium - COG1865 Uncharacterized conserved protein 0.579537 archaebacteria - COG4847 Uncharacterized protein conserved in archaea 0.578587 acidocaldarius - COG1865 Uncharacterized conserved protein 0.577381 archaeon - COG1340 Uncharacterized archaeal coiled-coil protein 0.576561 archaea - COG1449 Alpha-amylase/alpha-mannosidase 0.573276 archaebacterium - COG1709 Predicted transcriptional regulator 0.572893 acidocaldarius - NOG08298 non supervised orthologous group 0.572782 subunit - COG1899 Deoxyhypusine synthase 0.572273 ferredoxin - COG3431 Predicted membrane protein 0.572096 archaea - COG1340 Uncharacterized archaeal coiled-coil protein 0.571277 archaebacteria - COG1102 Cytidylate kinase 0.570059 thermophile - COG1865 Uncharacterized conserved protein 0.569272 archaebacterium - COG4754 Uncharacterized conserved protein 0.569124 acidocaldarius - COG4986 ABC-type anion transport system, duplicated permease component 0.568513 archaebacteria - COG1602 Uncharacterized conserved protein Cluster 55 ----------------------------------------------------------- 0.698883 lactam - COG2851 H+/citrate symporter 0.657612 lactamase - COG2851 H+/citrate symporter Cluster 56 ----------------------------------------------------------- 0.698103 implantation - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.693581 prosthesis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.689592 implant - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.686141 silicone - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.636345 chlorhexidine - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.613358 piperacillin - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.601399 vegetation - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.594674 ointment - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.585091 fibrosis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.582853 catheter - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.580992 imipenem - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 0.580490 heifer - COG1922 Teichoic acid biosynthesis proteins 0.571731 mastitis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Cluster 57 ----------------------------------------------------------- 0.697234 enterocolitis - COG4492 ACT domain-containing protein 0.646133 poisoning - COG4492 ACT domain-containing protein 0.608843 enterotoxin - COG4492 ACT domain-containing protein 0.591573 enterotoxin - COG1866 Phosphoenolpyruvate carboxykinase (ATP) Cluster 58 ----------------------------------------------------------- 0.696111 lincomycin - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components 0.649952 tylosin - COG1176 ABC-type spermidine/putrescine transport system, permease component I 0.647517 lincomycin - COG1264 Phosphotransferase system IIB components 0.639436 tylosin - COG1177 ABC-type spermidine/putrescine transport system, permease component II 0.628794 lincomycin - COG2190 Phosphotransferase system IIA components 0.623323 tylosin - COG1264 Phosphotransferase system IIB components 0.620411 tylosin - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components 0.619030 tylosin - COG0687 Spermidine/putrescine-binding periplasmic protein 0.614474 peptostreptococcus - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components 0.608555 lincomycin - COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific 0.574314 actinomyces - COG1264 Phosphotransferase system IIB components Cluster 59 ----------------------------------------------------------- 0.694926 glutamine - COG0464 ATPases of the AAA+ class 0.685561 subunit - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.680873 carbon - COG0464 ATPases of the AAA+ class 0.668795 acceptor - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.633317 crystallization - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.628714 dehydrogenase - COG0464 ATPases of the AAA+ class 0.614089 crystal - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.611695 coenzyme - COG0464 ATPases of the AAA+ class 0.604353 acceptor - COG0464 ATPases of the AAA+ class 0.586530 diffraction - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.586454 nitrogen - COG0464 ATPases of the AAA+ class 0.583577 sulphur - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.580831 glutamine - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.578200 crystallization - COG0689 RNase PH 0.578128 carbon - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 0.570769 dehydrogenase - COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cluster 60 ----------------------------------------------------------- 0.693662 succinate - COG1280 Putative threonine efflux protein 0.649501 coenzyme - COG1280 Putative threonine efflux protein 0.636418 ornithine - COG1129 ABC-type sugar transport system, ATPase component 0.624607 valine - COG2066 Glutaminase 0.597068 glutamine - COG2066 Glutaminase 0.595154 stoichiometry - COG2066 Glutaminase 0.587904 carboxylase - COG2066 Glutaminase 0.579301 repression - COG2066 Glutaminase 0.576781 homoserine - COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component 0.575250 thuringiensis - COG2066 Glutaminase 0.574514 homoserine - COG0559 Branched-chain amino acid ABC-type transport system, permease components 0.574514 homoserine - COG4177 ABC-type branched-chain amino acid transport system, permease component 0.574514 homoserine - COG0410 ABC-type branched-chain amino acid transport systems, ATPase component 0.569530 glutamate - COG2066 Glutaminase 0.568598 isomerase - COG1129 ABC-type sugar transport system, ATPase component Cluster 61 ----------------------------------------------------------- 0.693395 sewage - COG1749 Flagellar hook protein FlgE 0.658064 vegetable - COG1749 Flagellar hook protein FlgE 0.653167 sewage - COG1987 Flagellar biosynthesis pathway, component FliQ 0.653167 sewage - COG1684 Flagellar biosynthesis pathway, component FliR 0.653167 sewage - COG1677 Flagellar hook-basal body protein 0.653167 sewage - COG1868 Flagellar motor switch protein 0.653167 sewage - COG4786 Flagellar basal body rod protein 0.653167 sewage - COG1815 Flagellar basal body protein 0.653167 sewage - COG1843 Flagellar hook capping protein 0.646570 sewage - COG1558 Flagellar basal body rod protein 0.646570 sewage - COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 0.640902 sewage - COG1291 Flagellar motor component 0.640902 sewage - COG1344 Flagellin and related hook-associated proteins 0.640902 sewage - COG1360 Flagellar motor protein 0.625562 sewage - COG1516 Flagellin-specific chaperone FliS 0.625562 sewage - COG1345 Flagellar capping protein 0.618472 sewage - COG1256 Flagellar hook-associated protein 0.580537 vegetable - COG1291 Flagellar motor component 0.580537 vegetable - COG1360 Flagellar motor protein 0.580537 vegetable - COG1344 Flagellin and related hook-associated proteins 0.573854 sewage - COG1419 Flagellar GTP-binding protein 0.571962 vegetable - COG1815 Flagellar basal body protein 0.569559 carcass - COG1749 Flagellar hook protein FlgE Cluster 62 ----------------------------------------------------------- 0.690726 cytomegalovirus - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 0.684034 seropositivity - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 0.667871 serology - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 0.619011 seroprevalence - COG1664 Integral membrane protein CcmA involved in cell shape determination 0.613906 seropositivity - COG1664 Integral membrane protein CcmA involved in cell shape determination 0.594223 seropositivity - COG1579 Zn-ribbon protein, possibly nucleic acid-binding Cluster 63 ----------------------------------------------------------- 0.689823 lactamases - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.640737 lactamase - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.606231 lactam - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.587583 penicillin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 64 ----------------------------------------------------------- 0.689447 abortion - NOG08391 non supervised orthologous group 0.655282 abortion - COG4869 Propanediol utilization protein 0.654097 abortion - COG4769 Predicted membrane protein 0.625984 serovar - COG2918 Gamma-glutamylcysteine synthetase 0.621736 abortion - COG5341 Uncharacterized protein conserved in bacteria 0.621472 cytosol - COG4272 Predicted membrane protein 0.619708 serovar - COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC 0.612642 abortion - COG3933 Transcriptional antiterminator 0.605800 abortion - COG4194 Predicted membrane protein 0.603230 cytosol - COG4194 Predicted membrane protein 0.602641 serovars - COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC 0.600340 serovars - COG4194 Predicted membrane protein 0.599431 serovars - COG2918 Gamma-glutamylcysteine synthetase 0.598282 abortion - COG3580 Uncharacterized protein conserved in bacteria 0.597092 abortion - COG4905 Predicted membrane protein 0.594541 serovar - COG4869 Propanediol utilization protein 0.590293 abortion - COG4909 Propanediol dehydratase, large subunit 0.590293 abortion - COG4910 Propanediol dehydratase, small subunit 0.586399 serovars - COG4869 Propanediol utilization protein 0.582020 serovar - COG4194 Predicted membrane protein 0.580285 abortion - COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC 0.579852 serovars - NOG08391 non supervised orthologous group 0.579838 cytosol - COG3933 Transcriptional antiterminator Cluster 65 ----------------------------------------------------------- 0.687501 purpura - COG3512 Uncharacterized protein conserved in bacteria 0.679990 counterimmunoelectrophoresis - COG3475 LPS biosynthesis protein 0.677781 polysaccharide - COG3512 Uncharacterized protein conserved in bacteria 0.663079 purpura - COG3475 LPS biosynthesis protein 0.637002 pneumococcus - COG3475 LPS biosynthesis protein 0.609618 polysaccharide - COG3475 LPS biosynthesis protein 0.609277 school - COG3512 Uncharacterized protein conserved in bacteria 0.608254 pneumococcus - COG3512 Uncharacterized protein conserved in bacteria 0.604466 capsule - COG3512 Uncharacterized protein conserved in bacteria 0.596736 cefaclor - COG3475 LPS biosynthesis protein Cluster 66 ----------------------------------------------------------- 0.686826 serotyping - COG2855 Predicted membrane protein 0.630498 serotyping - COG2932 Predicted transcriptional regulator 0.591783 serotype - COG2855 Predicted membrane protein 0.578232 serotypes - COG2855 Predicted membrane protein Cluster 67 ----------------------------------------------------------- 0.685775 clindamycin - COG2035 Predicted membrane protein 0.643312 faecalis - COG3764 Sortase (surface protein transpeptidase) 0.622727 clindamycin - COG1621 Beta-fructosidases (levanase/invertase) 0.604867 enterococci - COG3764 Sortase (surface protein transpeptidase) 0.592957 enterococcus - COG3764 Sortase (surface protein transpeptidase) Cluster 68 ----------------------------------------------------------- 0.685462 planta - COG5255 Uncharacterized protein conserved in bacteria 0.666734 tobacco - NOG07139 non supervised orthologous group 0.649299 tobacco - COG5343 Uncharacterized protein conserved in bacteria 0.631920 planta - COG5343 Uncharacterized protein conserved in bacteria 0.623655 planta - NOG07139 non supervised orthologous group 0.622604 tomato - COG3533 Uncharacterized protein conserved in bacteria 0.621199 planta - COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain 0.621198 planta - COG3569 Topoisomerase IB 0.617508 tobacco - NOG04033 non supervised orthologous group 0.617228 tobacco - COG5255 Uncharacterized protein conserved in bacteria 0.615464 tobacco - COG5278 Predicted periplasmic ligand-binding sensor domain 0.610673 tobacco - COG4922 Uncharacterized protein conserved in bacteria 0.609982 tobacco - COG4692 Predicted neuraminidase (sialidase) 0.606541 glucuronidase - COG0562 UDP-galactopyranose mutase 0.602320 glucuronidase - COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif 0.598245 planta - COG3534 Alpha-L-arabinofuranosidase 0.592644 tobacco - COG3569 Topoisomerase IB 0.592173 tomato - NOG07139 non supervised orthologous group 0.589960 planta - COG3533 Uncharacterized protein conserved in bacteria 0.588181 potato - COG3533 Uncharacterized protein conserved in bacteria 0.586456 glucuronidase - COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) 0.586299 tobacco - COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) 0.581278 tobacco - COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif Cluster 69 ----------------------------------------------------------- 0.683019 tobacco - COG4711 Predicted membrane protein 0.626398 plastid - COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family 0.610449 transcript - COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family 0.606565 tobacco - COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family 0.601674 planta - COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family 0.598638 tobacco - COG3755 Uncharacterized protein conserved in bacteria 0.587399 tobacco - COG3932 Uncharacterized ABC-type transport system, permease components 0.586370 tobacco - COG2214 DnaJ-class molecular chaperone 0.581244 glucuronidase - COG3685 Uncharacterized protein conserved in bacteria 0.575898 transcript - COG3932 Uncharacterized ABC-type transport system, permease components 0.573826 plastid - COG3932 Uncharacterized ABC-type transport system, permease components Cluster 70 ----------------------------------------------------------- 0.682889 transl - COG1278 Cold shock proteins 0.666526 transl - COG1841 Ribosomal protein L30/L7E 0.618197 transl - COG4974 Site-specific recombinase XerD Cluster 71 ----------------------------------------------------------- 0.682042 avirulence - COG4099 Predicted peptidase 0.625902 avirulence - NOG05832 non supervised orthologous group Cluster 72 ----------------------------------------------------------- 0.681377 subunit - COG0530 Ca2+/Na+ antiporter 0.645887 atpase - COG0530 Ca2+/Na+ antiporter 0.610674 thymine - COG3144 Flagellar hook-length control protein 0.607238 stoichiometry - COG0530 Ca2+/Na+ antiporter 0.585709 archaea - COG0530 Ca2+/Na+ antiporter 0.583986 acidocaldarius - COG1986 Uncharacterized conserved protein 0.582246 succinate - COG2718 Uncharacterized conserved protein 0.582246 succinate - COG2766 Putative Ser protein kinase 0.571659 insect - COG3144 Flagellar hook-length control protein Cluster 73 ----------------------------------------------------------- 0.680499 difficile - COG1978 Uncharacterized protein conserved in bacteria 0.676666 difficile - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.654976 hamster - COG1306 Uncharacterized conserved protein 0.638569 hamster - COG1406 Predicted inhibitor of MCP methylation, homolog of CheC 0.628044 hamster - COG1315 Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain 0.596957 hamster - COG1582 Uncharacterized protein, possibly involved in motility 0.596296 antitoxin - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.596152 spirochaete - COG1306 Uncharacterized conserved protein 0.590940 antitoxin - NOG08016 non supervised orthologous group 0.580503 colitis - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cluster 74 ----------------------------------------------------------- 0.678489 lipopolysaccharides - COG4105 DNA uptake lipoprotein 0.646021 lipopolysaccharide - COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase 0.646021 lipopolysaccharide - COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase 0.646021 lipopolysaccharide - COG1519 3-deoxy-D-manno-octulosonic-acid transferase 0.644819 lipopolysaccharide - COG1663 Tetraacyldisaccharide-1-P 4-kinase 0.629351 lipopolysaccharides - COG1452 Organic solvent tolerance protein OstA 0.625804 lipopolysaccharides - COG1629 Outer membrane receptor proteins, mostly Fe transport 0.618366 lipopolysaccharides - COG1663 Tetraacyldisaccharide-1-P 4-kinase 0.617446 lipopolysaccharides - COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase 0.617446 lipopolysaccharides - COG1519 3-deoxy-D-manno-octulosonic-acid transferase 0.617446 lipopolysaccharides - COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase 0.617282 lipopolysaccharide - COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains 0.616824 lipopolysaccharides - COG2908 Uncharacterized protein conserved in bacteria 0.589468 lipopolysaccharides - COG2067 Long-chain fatty acid transport protein Cluster 75 ----------------------------------------------------------- 0.677457 gonococcus - COG3219 Uncharacterized protein conserved in bacteria 0.654410 capsule - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.637481 nasopharynx - COG3219 Uncharacterized protein conserved in bacteria 0.635141 gonorrhoeae - COG3219 Uncharacterized protein conserved in bacteria 0.633477 capsule - COG3778 Uncharacterized protein conserved in bacteria 0.630829 gonococcus - COG3767 Uncharacterized low-complexity protein 0.620755 capsular - COG3778 Uncharacterized protein conserved in bacteria 0.603473 counterimmunoelectrophoresis - COG3219 Uncharacterized protein conserved in bacteria 0.582054 septicaemia - COG3219 Uncharacterized protein conserved in bacteria 0.579660 gonorrhoeae - COG3215 Tfp pilus assembly protein PilZ 0.573108 capsular - COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 0.571717 gonorrhoeae - COG3767 Uncharacterized low-complexity protein Cluster 76 ----------------------------------------------------------- 0.677259 peptostreptococcus - COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes 0.631384 bacteroides - COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes Cluster 77 ----------------------------------------------------------- 0.677091 seedling - COG3910 Predicted ATPase 0.662652 seedling - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 0.610448 seedling - COG3665 Uncharacterized conserved protein 0.607159 rhizobium - COG3910 Predicted ATPase 0.592611 homoserine - COG1593 TRAP-type C4-dicarboxylate transport system, large permease component 0.589968 planta - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 0.589912 seedling - COG1593 TRAP-type C4-dicarboxylate transport system, large permease component 0.585456 azotobacter - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 0.584282 proteobacteria - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 0.576739 homoserine - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 0.575434 rhizobium - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 0.572448 periplasm - COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component Cluster 78 ----------------------------------------------------------- 0.676559 fibrinogen - COG3942 Surface antigen 0.665984 osteomyelitis - COG3942 Surface antigen 0.637093 diabetes - COG3442 Predicted glutamine amidotransferase 0.631489 endocarditis - COG3942 Surface antigen 0.599699 diabetes - COG4720 Predicted membrane protein 0.596252 dermatitis - COG3942 Surface antigen Cluster 79 ----------------------------------------------------------- 0.674879 biovars - COG3459 Cellobiose phosphorylase 0.619869 cytosol - COG3459 Cellobiose phosphorylase 0.596795 cytosol - COG1803 Methylglyoxal synthase Cluster 80 ----------------------------------------------------------- 0.674477 counterimmunoelectrophoresis - COG4797 Predicted regulatory domain of a methyltransferase 0.671772 gonococcus - COG4797 Predicted regulatory domain of a methyltransferase 0.643406 purpura - COG4797 Predicted regulatory domain of a methyltransferase 0.632971 capsular - COG3514 Uncharacterized protein conserved in bacteria 0.624693 gonococcus - COG5266 ABC-type Co2+ transport system, periplasmic component 0.620431 gonorrhoeae - COG4797 Predicted regulatory domain of a methyltransferase 0.618469 nasopharynx - COG4797 Predicted regulatory domain of a methyltransferase 0.609904 gonococcus - COG4314 Predicted lipoprotein involved in nitrous oxide reduction 0.603082 gonococcus - COG3420 Nitrous oxidase accessory protein 0.592674 gonococcus - COG3901 Regulator of nitric oxide reductase transcription 0.589806 branhamella - COG4797 Predicted regulatory domain of a methyltransferase 0.586116 purpura - COG4391 Uncharacterized protein conserved in bacteria 0.577352 polysaccharide - COG4797 Predicted regulatory domain of a methyltransferase 0.576077 counterimmunoelectrophoresis - COG5266 ABC-type Co2+ transport system, periplasmic component 0.569925 counterimmunoelectrophoresis - COG4942 Membrane-bound metallopeptidase Cluster 81 ----------------------------------------------------------- 0.673853 institution - COG4732 Predicted membrane protein 0.622113 debridement - COG4732 Predicted membrane protein 0.618792 ciprofloxacin - COG3002 Uncharacterized protein conserved in bacteria 0.615975 drainage - COG4732 Predicted membrane protein 0.613689 peritonitis - COG4732 Predicted membrane protein 0.582483 syndrome - COG4619 ABC-type uncharacterized transport system, ATPase component 0.581991 empyema - COG4732 Predicted membrane protein 0.574208 peritonitis - NOG08620 non supervised orthologous group 0.573526 ciprofloxacin - COG4732 Predicted membrane protein 0.573088 fibronectin - COG4732 Predicted membrane protein Cluster 82 ----------------------------------------------------------- 0.673300 multilocus - COG3658 Cytochrome b 0.606575 multilocus - COG3926 Putative secretion activating protein 0.593548 multilocus - COG3310 Uncharacterized protein conserved in bacteria Cluster 83 ----------------------------------------------------------- 0.672942 exopolysaccharide - COG5394 Uncharacterized protein conserved in bacteria 0.662449 exopolysaccharide - COG4798 Predicted methyltransferase 0.651510 exopolysaccharide - COG5267 Uncharacterized protein conserved in bacteria 0.651510 exopolysaccharide - COG4102 Uncharacterized protein conserved in bacteria 0.635627 exopolysaccharide - NOG08575 non supervised orthologous group 0.611548 exopolysaccharide - COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain 0.598614 exopolysaccharide - COG4553 Poly-beta-hydroxyalkanoate depolymerase (probably not required for symbiosis, but it has been proposed to be essential for the non-symbiotic state of Rhizobia (LARA L. MADISON AND GJALT W. HUISMAN, 1999) -> might thus be essential for re-infection... Moreover, a might turn off the PHA system for symbiosis, since it depolymerises the carbon storage molecule PHA 0.593218 maltophilia - NOG08575 non supervised orthologous group Cluster 84 ----------------------------------------------------------- 0.672436 purpura - COG3692 Uncharacterized protein conserved in bacteria 0.613709 purpura - COG2830 Uncharacterized protein conserved in bacteria 0.598971 counterimmunoelectrophoresis - COG2830 Uncharacterized protein conserved in bacteria 0.596753 purpura - COG3562 Capsule polysaccharide export protein 0.596753 purpura - COG3563 Capsule polysaccharide export protein 0.589884 polysaccharide - COG3779 Uncharacterized protein conserved in bacteria 0.573865 mucosa - COG3587 Restriction endonuclease 0.573504 purpura - COG3524 Capsule polysaccharide export protein 0.570855 polysaccharide - NOG26251 non supervised orthologous group Cluster 85 ----------------------------------------------------------- 0.672117 coccus - COG2610 H+/gluconate symporter and related permeases 0.582013 coccus - COG1380 Putative effector of murein hydrolase LrgA 0.574059 coccus - COG1346 Putative effector of murein hydrolase Cluster 86 ----------------------------------------------------------- 0.671243 mammal - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.631290 enterocolitica - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.611201 pseudotuberculosis - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.593365 brucellosis - COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components 0.590989 rattus - COG4929 Uncharacterized membrane-anchored protein Cluster 87 ----------------------------------------------------------- 0.670926 rattus - COG1704 Uncharacterized conserved protein Cluster 88 ----------------------------------------------------------- 0.670737 xylanases - COG2364 Predicted membrane protein 0.669490 dehydratase - COG3973 Superfamily I DNA and RNA helicases 0.666594 arthrobacter - COG3973 Superfamily I DNA and RNA helicases 0.666472 xylanase - COG2364 Predicted membrane protein 0.663995 formate - COG4978 Transcriptional regulator, effector-binding domain/component 0.662631 stearothermophilus - COG2720 Uncharacterized vancomycin resistance protein 0.659944 xylanase - COG3973 Superfamily I DNA and RNA helicases 0.654190 coenzyme - COG4978 Transcriptional regulator, effector-binding domain/component 0.638536 starch - COG2364 Predicted membrane protein 0.638375 xylanases - COG3973 Superfamily I DNA and RNA helicases 0.626794 glutamine - COG4978 Transcriptional regulator, effector-binding domain/component 0.626150 starch - COG3973 Superfamily I DNA and RNA helicases 0.621146 biodegradation - COG2720 Uncharacterized vancomycin resistance protein 0.620047 stoichiometry - COG4978 Transcriptional regulator, effector-binding domain/component 0.610047 glucanase - COG2364 Predicted membrane protein 0.607397 nitrophenyl - COG3973 Superfamily I DNA and RNA helicases 0.602900 decarboxylase - COG3973 Superfamily I DNA and RNA helicases 0.601040 amylase - COG3973 Superfamily I DNA and RNA helicases 0.598716 eubacteria - COG2720 Uncharacterized vancomycin resistance protein 0.596350 cellulase - COG3973 Superfamily I DNA and RNA helicases 0.594417 endoglucanase - COG3973 Superfamily I DNA and RNA helicases 0.592640 ornithine - COG3973 Superfamily I DNA and RNA helicases 0.592505 semialdehyde - COG2720 Uncharacterized vancomycin resistance protein 0.591070 pyridoxal - COG4978 Transcriptional regulator, effector-binding domain/component 0.589951 glucanase - COG3973 Superfamily I DNA and RNA helicases 0.589479 semialdehyde - COG4978 Transcriptional regulator, effector-binding domain/component 0.587260 glutamate - COG4978 Transcriptional regulator, effector-binding domain/component 0.587192 catabolite - COG2720 Uncharacterized vancomycin resistance protein 0.585506 dehydratase - COG2720 Uncharacterized vancomycin resistance protein 0.583928 amylase - COG2364 Predicted membrane protein 0.583658 toluene - COG2720 Uncharacterized vancomycin resistance protein 0.581110 thiamine - COG4978 Transcriptional regulator, effector-binding domain/component 0.580392 nitrophenyl - COG2364 Predicted membrane protein 0.576543 coenzyme - COG2720 Uncharacterized vancomycin resistance protein 0.574619 cellulase - COG2364 Predicted membrane protein 0.574593 thermophile - COG4978 Transcriptional regulator, effector-binding domain/component 0.572635 arthrobacter - COG2364 Predicted membrane protein Cluster 89 ----------------------------------------------------------- 0.669676 stomach - COG1749 Flagellar hook protein FlgE 0.639594 stomach - COG1706 Flagellar basal-body P-ring protein 0.626724 stomach - COG1261 Flagellar basal body P-ring biosynthesis protein 0.626724 stomach - COG2063 Flagellar basal body L-ring protein 0.604248 cytotoxin - COG1580 Flagellar basal body-associated protein 0.595134 cytotoxin - COG1749 Flagellar hook protein FlgE 0.594815 intestine - COG1291 Flagellar motor component 0.594815 intestine - COG1344 Flagellin and related hook-associated proteins 0.594815 intestine - COG1360 Flagellar motor protein 0.587680 stomach - COG1291 Flagellar motor component 0.587680 stomach - COG1360 Flagellar motor protein 0.587680 stomach - COG1344 Flagellin and related hook-associated proteins 0.584949 intestine - COG1749 Flagellar hook protein FlgE 0.576334 cytotoxin - COG1261 Flagellar basal body P-ring biosynthesis protein 0.576334 cytotoxin - COG2063 Flagellar basal body L-ring protein 0.576259 stomach - COG1345 Flagellar capping protein 0.576259 stomach - COG1516 Flagellin-specific chaperone FliS 0.575258 cytotoxin - COG1706 Flagellar basal-body P-ring protein 0.571665 cytotoxin - COG1360 Flagellar motor protein 0.571665 cytotoxin - COG1291 Flagellar motor component 0.571665 cytotoxin - COG1344 Flagellin and related hook-associated proteins 0.569799 intestine - COG1516 Flagellin-specific chaperone FliS 0.569799 intestine - COG1345 Flagellar capping protein Cluster 90 ----------------------------------------------------------- 0.667965 fragilis - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.608594 bacteroides - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.571870 coccus - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 91 ----------------------------------------------------------- 0.667103 multilocus - COG3513 Uncharacterized protein conserved in bacteria 0.625925 fatality - COG3512 Uncharacterized protein conserved in bacteria 0.608078 chemoprophylaxis - COG3512 Uncharacterized protein conserved in bacteria 0.588649 fatality - COG3475 LPS biosynthesis protein 0.582854 fatality - COG3633 symporter of unknown function (prev. Na+/serine symporter, or dicarboxylate symporter) 0.577643 meningitis - COG3513 Uncharacterized protein conserved in bacteria 0.574889 household - COG3512 Uncharacterized protein conserved in bacteria Cluster 92 ----------------------------------------------------------- 0.666893 thermophile - COG1728 Uncharacterized protein conserved in bacteria 0.664958 stearothermophilus - COG1728 Uncharacterized protein conserved in bacteria 0.653369 thuringiensis - COG1728 Uncharacterized protein conserved in bacteria 0.651693 thermophile - COG1582 Uncharacterized protein, possibly involved in motility 0.651674 thermophile - NOG14705 non supervised orthologous group 0.644677 germination - COG2359 Sporulation protein (previously annot. as uncharacterized) 0.639940 glucanase - COG1728 Uncharacterized protein conserved in bacteria 0.638614 stearothermophilus - NOG14705 non supervised orthologous group 0.636394 germination - COG3773 Cell wall hydrolyses involved in spore germination 0.630757 thymine - COG1582 Uncharacterized protein, possibly involved in motility 0.623629 thuringiensis - NOG14705 non supervised orthologous group 0.619741 thuringiensis - COG3773 Cell wall hydrolyses involved in spore germination 0.619496 thermophile - COG4200 Uncharacterized protein conserved in bacteria 0.618144 glucanase - NOG14705 non supervised orthologous group 0.615637 catalysis - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.615330 xylanase - COG2359 Sporulation protein (previously annot. as uncharacterized) 0.614208 stearothermophilus - COG1582 Uncharacterized protein, possibly involved in motility 0.612128 germination - COG1728 Uncharacterized protein conserved in bacteria 0.609038 barley - COG2359 Sporulation protein (previously annot. as uncharacterized) 0.605117 glucanase - COG2359 Sporulation protein (previously annot. as uncharacterized) 0.600675 thermophile - COG3874 Uncharacterized conserved protein 0.597851 xylanase - COG1728 Uncharacterized protein conserved in bacteria 0.596369 barley - COG1728 Uncharacterized protein conserved in bacteria 0.595381 guanine - NOG09692 non supervised orthologous group 0.590489 glucanase - COG4200 Uncharacterized protein conserved in bacteria 0.589879 catalysis - NOG09692 non supervised orthologous group 0.587097 barley - COG3773 Cell wall hydrolyses involved in spore germination 0.586122 germination - NOG14705 non supervised orthologous group 0.585588 malate - NOG09692 non supervised orthologous group 0.584953 holoenzyme - COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 0.583229 thermophile - NOG09692 non supervised orthologous group 0.575649 xylanases - COG2359 Sporulation protein (previously annot. as uncharacterized) 0.575032 thymine - COG1728 Uncharacterized protein conserved in bacteria 0.573230 germination - COG3874 Uncharacterized conserved protein 0.572373 glucanase - COG3773 Cell wall hydrolyses involved in spore germination 0.571895 thuringiensis - COG1582 Uncharacterized protein, possibly involved in motility 0.571863 thermostability - COG1582 Uncharacterized protein, possibly involved in motility 0.569537 glucans - NOG09692 non supervised orthologous group Cluster 93 ----------------------------------------------------------- 0.664271 opsonization - COG4300 Predicted permease, cadmium resistance protein 0.645275 empyema - COG4300 Predicted permease, cadmium resistance protein 0.612727 empyema - COG2932 Predicted transcriptional regulator 0.604662 institution - COG4300 Predicted permease, cadmium resistance protein 0.589598 childhood - COG4300 Predicted permease, cadmium resistance protein 0.584422 opsonization - COG2855 Predicted membrane protein 0.570529 hospitalization - COG4300 Predicted permease, cadmium resistance protein Cluster 94 ----------------------------------------------------------- 0.662754 leukocytes - COG4413 Urea transporter 0.654441 abscess - COG4413 Urea transporter 0.649511 ciprofloxacin - COG4413 Urea transporter 0.630278 suspicion - COG4413 Urea transporter 0.621087 ofloxacin - COG4413 Urea transporter 0.610465 leukocytes - COG3477 Predicted periplasmic/secreted protein 0.607132 drainage - COG4413 Urea transporter 0.595785 fibronectin - COG4413 Urea transporter 0.590094 debridement - COG4413 Urea transporter 0.583780 ciprofloxacin - COG3477 Predicted periplasmic/secreted protein Cluster 95 ----------------------------------------------------------- 0.662557 bacteriocins - COG1434 Uncharacterized conserved protein 0.643297 starter - COG3104 Dipeptide/tripeptide permease 0.630523 coliforms - COG1434 Uncharacterized conserved protein 0.626512 lecithinase - COG1434 Uncharacterized conserved protein 0.625879 spoilage - COG1434 Uncharacterized conserved protein 0.620207 sausage - COG3104 Dipeptide/tripeptide permease 0.616856 starter - COG1434 Uncharacterized conserved protein 0.597331 cheese - COG3104 Dipeptide/tripeptide permease 0.594727 fermentation - COG0514 Superfamily II DNA helicase 0.591357 bacteriocin - COG1434 Uncharacterized conserved protein 0.589186 haemolysis - COG3104 Dipeptide/tripeptide permease 0.582445 peptone - COG3104 Dipeptide/tripeptide permease 0.582040 broiler - COG1434 Uncharacterized conserved protein 0.581489 spoilage - COG3104 Dipeptide/tripeptide permease 0.580719 cheese - COG1434 Uncharacterized conserved protein 0.569529 haemolysis - COG1434 Uncharacterized conserved protein Cluster 96 ----------------------------------------------------------- 0.662066 stenotrophomonas - COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 0.634315 acinetobacter - COG4726 Tfp pilus assembly protein PilX 0.627208 acinetobacter - COG4966 Tfp pilus assembly protein PilW 0.602297 acinetobacter - COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 0.591574 acinetobacter - COG3241 Azurin 0.574806 acinetobacter - COG3215 Tfp pilus assembly protein PilZ Cluster 97 ----------------------------------------------------------- 0.661117 serology - NOG08579 non supervised orthologous group 0.577018 seroprevalence - NOG08579 non supervised orthologous group 0.575795 seropositivity - NOG08579 non supervised orthologous group Cluster 98 ----------------------------------------------------------- 0.660809 gangrene - NOG13102 non supervised orthologous group 0.644855 bacteroides - NOG13102 non supervised orthologous group 0.609040 bacteroides - NOG16465 non supervised orthologous group Cluster 99 ----------------------------------------------------------- 0.660460 haemolysin - NOG26252 non supervised orthologous group 0.611713 haemolysis - NOG26252 non supervised orthologous group Cluster 100 ----------------------------------------------------------- 0.658647 serogroup - COG1652 Uncharacterized protein containing LysM domain 0.640528 serogroups - COG1652 Uncharacterized protein containing LysM domain 0.628031 heptose - COG1652 Uncharacterized protein containing LysM domain 0.617057 serogroup - COG3658 Cytochrome b 0.605499 serogroups - COG3658 Cytochrome b 0.599856 serogroup - COG3926 Putative secretion activating protein 0.581685 heptose - COG3658 Cytochrome b Cluster 101 ----------------------------------------------------------- 0.658309 glycosyltransferase - NOG06523 Endo-1,4-beta xylanase (Xylanase D) Cluster 102 ----------------------------------------------------------- 0.657689 antitoxin - NOG14203 non supervised orthologous group 0.585043 toxigenic - NOG14203 non supervised orthologous group Cluster 103 ----------------------------------------------------------- 0.657399 toluene - COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains 0.620544 toluene - COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis. 0.596470 biodegradation - COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis. 0.590805 catechol - COG4728 Uncharacterized protein conserved in bacteria 0.588710 catechol - COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains 0.580289 biodegradation - COG4728 Uncharacterized protein conserved in bacteria 0.574224 alginate - COG4728 Uncharacterized protein conserved in bacteria 0.570264 catechol - COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis. Cluster 104 ----------------------------------------------------------- 0.656584 infection - COG0782 Transcription elongation factor 0.642283 pathogen - COG0782 Transcription elongation factor 0.611273 infection - COG0208 Ribonucleotide reductase, beta subunit Cluster 105 ----------------------------------------------------------- 0.656072 bacteroides - NOG14203 non supervised orthologous group 0.631157 fragilis - NOG14203 non supervised orthologous group 0.619978 peptostreptococcus - NOG14203 non supervised orthologous group 0.617490 clindamycin - NOG14203 non supervised orthologous group 0.588879 actinomyces - COG3472 Uncharacterized conserved protein 0.573266 actinomyces - NOG13320 non supervised orthologous group Cluster 106 ----------------------------------------------------------- 0.654856 emergency - COG0749 DNA polymerase I - 3-5 exonuclease and polymerase domains 0.641416 country - COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) 0.629228 country - COG1862 Preprotein translocase subunit YajC 0.623741 health - COG1862 Preprotein translocase subunit YajC 0.614531 prevention - COG1862 Preprotein translocase subunit YajC 0.612696 person - COG1862 Preprotein translocase subunit YajC 0.608376 emergency - COG1570 Exonuclease VII, large subunit 0.603078 emergency - COG1722 Exonuclease VII small subunit 0.598648 epidemiology - COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) 0.597953 individual - COG1862 Preprotein translocase subunit YajC 0.579165 incidence - COG1862 Preprotein translocase subunit YajC 0.577186 subject - COG1862 Preprotein translocase subunit YajC 0.573565 prevention - COG1570 Exonuclease VII, large subunit 0.572664 person - COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) Cluster 107 ----------------------------------------------------------- 0.654647 chlorhexidine - COG1514 2-5 RNA ligase 0.651162 enterobacter - COG1514 2-5 RNA ligase 0.642740 device - COG1514 2-5 RNA ligase 0.618893 bacteriuria - COG1514 2-5 RNA ligase 0.618558 ointment - COG1514 2-5 RNA ligase 0.602750 catheter - COG1785 Alkaline phosphatase 0.584092 cefazolin - COG1514 2-5 RNA ligase 0.570835 heifer - COG1514 2-5 RNA ligase Cluster 108 ----------------------------------------------------------- 0.654406 germination - COG1001 Adenine deaminase 0.608157 thermophilus - COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain 0.602966 flagellin - COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain 0.575938 filament - COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain 0.571235 formate - COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Cluster 109 ----------------------------------------------------------- 0.653925 sanguis - COG4475 Uncharacterized protein conserved in bacteria 0.570434 coagulation - COG1288 Predicted membrane protein Cluster 110 ----------------------------------------------------------- 0.653629 fixation - COG4095 Uncharacterized conserved protein 0.621839 fixation - COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains 0.621839 fixation - COG1348 Nitrogenase subunit NifH (ATPase) Cluster 111 ----------------------------------------------------------- 0.653367 monocytogene - NOG20091 non supervised orthologous group 0.622229 starter - COG4932 Predicted outer membrane protein 0.622035 phospholipase - COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain 0.621031 bacteriocin - COG3962 Acetolactate synthase 0.617549 bacteriocin - COG3718 Uncharacterized enzyme involved in inositol metabolism 0.602377 phosphoprotein - COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain 0.599921 starter - COG2746 Aminoglycoside N3-acetyltransferase 0.590774 vacuum - COG3718 Uncharacterized enzyme involved in inositol metabolism 0.589057 vacuum - COG3962 Acetolactate synthase 0.587564 vegetable - COG3325 Chitinase 0.585988 bacteriocins - COG4932 Predicted outer membrane protein 0.579051 xylose - COG3718 Uncharacterized enzyme involved in inositol metabolism Cluster 112 ----------------------------------------------------------- 0.651428 coccus - COG2348 Uncharacterized protein involved in methicillin resistance 0.587471 enterococci - COG4716 Myosin-crossreactive antigen Cluster 113 ----------------------------------------------------------- 0.650928 toxigenic - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.639972 antitoxin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.625376 enterotoxin - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 114 ----------------------------------------------------------- 0.650240 tetramer - COG1051 ADP-ribose pyrophosphatase 0.638081 catalysis - COG1051 ADP-ribose pyrophosphatase 0.616126 represser - COG2771 DNA-binding HTH domain-containing proteins 0.591059 promoter - COG1051 ADP-ribose pyrophosphatase Cluster 115 ----------------------------------------------------------- 0.649856 diarrhea - COG3681 Uncharacterized conserved protein 0.639095 colitis - NOG04347 non supervised orthologous group 0.637330 diarrhea - NOG04347 non supervised orthologous group 0.629379 enterotoxin - COG3314 Uncharacterized protein conserved in bacteria 0.626910 diarrhoea - NOG04347 non supervised orthologous group 0.620721 colitis - COG3681 Uncharacterized conserved protein 0.612223 diarrhoea - COG3681 Uncharacterized conserved protein 0.603075 colitis - COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB 0.587415 enteritis - COG3681 Uncharacterized conserved protein 0.583227 diarrhea - COG3033 Tryptophanase 0.582884 enteritis - NOG04347 non supervised orthologous group 0.579266 diarrhea - COG3314 Uncharacterized protein conserved in bacteria 0.569657 diarrhoea - COG3033 Tryptophanase Cluster 116 ----------------------------------------------------------- 0.649747 abortion - NOG08857 non supervised orthologous group 0.641821 serovars - NOG08857 non supervised orthologous group 0.632472 serovars - COG4748 Uncharacterized conserved protein 0.623063 serovar - NOG08857 non supervised orthologous group 0.604403 abortion - COG4748 Uncharacterized conserved protein 0.600106 serovar - COG4748 Uncharacterized conserved protein 0.578963 serovars - COG4912 Predicted DNA alkylation repair enzyme 0.568674 brucellosis - NOG08857 non supervised orthologous group Cluster 117 ----------------------------------------------------------- 0.648708 phospholipase - COG0232 dGTP triphosphohydrolase Cluster 118 ----------------------------------------------------------- 0.648538 maltophilia - COG4913 Uncharacterized protein conserved in bacteria 0.603640 exopolysaccharide - COG5373 Predicted membrane protein 0.602629 ceftazidime - COG4913 Uncharacterized protein conserved in bacteria 0.596848 cefoperazone - COG4913 Uncharacterized protein conserved in bacteria 0.589777 ceftazidime - COG4924 Uncharacterized protein conserved in bacteria 0.576818 cefoperazone - COG4924 Uncharacterized protein conserved in bacteria Cluster 119 ----------------------------------------------------------- 0.648205 macrolide - COG2503 Predicted secreted acid phosphatase 0.590928 macrolides - COG2503 Predicted secreted acid phosphatase 0.584243 aminoglycoside - COG4264 Siderophore synthetase component 0.577994 macrolide - COG4594 ABC-type Fe3+-citrate transport system, periplasmic component Cluster 120 ----------------------------------------------------------- 0.647386 conjunctivitis - COG1925 Phosphotransferase system, HPr-related proteins 0.587990 conjunctivitis - COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Cluster 121 ----------------------------------------------------------- 0.646732 nitrogenase - COG3411 Ferredoxin 0.635837 starvation - COG1512 Beta-propeller domains of methanol dehydrogenase type 0.610855 ferredoxin - COG3411 Ferredoxin 0.609868 sorbitol - COG1512 Beta-propeller domains of methanol dehydrogenase type 0.600653 nitrogen - COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit 0.599107 holoenzyme - COG1512 Beta-propeller domains of methanol dehydrogenase type 0.592593 nitrogen - COG3411 Ferredoxin 0.581098 glutamine - COG3411 Ferredoxin Cluster 122 ----------------------------------------------------------- 0.646496 anaerobe - COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen 0.584241 actinomyces - NOG06509 non supervised orthologous group Cluster 123 ----------------------------------------------------------- 0.646416 microflora - NOG06584 non supervised orthologous group 0.636013 biotransformation - COG3973 Superfamily I DNA and RNA helicases 0.632449 fermentation - COG3973 Superfamily I DNA and RNA helicases 0.623396 microflora - NOG14535 non supervised orthologous group 0.614959 epsilon - COG3973 Superfamily I DNA and RNA helicases 0.597091 epsilon - COG2720 Uncharacterized vancomycin resistance protein 0.579237 propionate - NOG06584 non supervised orthologous group 0.578897 epsilon - NOG14535 non supervised orthologous group 0.572692 epsilon - NOG06584 non supervised orthologous group Cluster 124 ----------------------------------------------------------- 0.645855 aminoglycoside - COG4413 Urea transporter Cluster 125 ----------------------------------------------------------- 0.645642 citrate - COG1226 Kef-type K+ transport systems, predicted NAD-binding component Cluster 126 ----------------------------------------------------------- 0.644304 isolate - COG1636 Uncharacterized protein conserved in bacteria 0.603780 lactamase - COG1636 Uncharacterized protein conserved in bacteria Cluster 127 ----------------------------------------------------------- 0.643729 poisoning - COG1434 Uncharacterized conserved protein Cluster 128 ----------------------------------------------------------- 0.643437 rifampicin - COG4974 Site-specific recombinase XerD 0.590061 rifampicin - COG1278 Cold shock proteins Cluster 129 ----------------------------------------------------------- 0.642821 succinate - COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains 0.636370 starvation - COG4147 Predicted symporter 0.626859 glutamine - COG2059 Chromate transport protein ChrA 0.626572 succinate - NOG28953 non supervised orthologous group 0.617777 succinate - COG2059 Chromate transport protein ChrA 0.609567 carbon - COG2059 Chromate transport protein ChrA 0.608505 alcaligenes - COG2059 Chromate transport protein ChrA 0.606884 ammonia - COG2059 Chromate transport protein ChrA 0.603506 semialdehyde - COG2059 Chromate transport protein ChrA 0.600428 valine - COG4147 Predicted symporter 0.597710 catalysis - COG1033 Predicted exporters of the RND superfamily 0.594995 isomerase - COG4147 Predicted symporter 0.594024 biodegradation - COG4147 Predicted symporter 0.589967 azotobacter - COG2059 Chromate transport protein ChrA 0.574927 fumarate - COG2059 Chromate transport protein ChrA 0.574300 succinate - COG4666 TRAP-type uncharacterized transport system, fused permease components Cluster 130 ----------------------------------------------------------- 0.641820 sanguis - COG3981 Predicted acetyltransferase 0.629087 sanguis - COG2035 Predicted membrane protein 0.622644 tonsillitis - COG2035 Predicted membrane protein 0.609668 endophthalmitis - COG4721 Predicted membrane protein 0.602971 colonization - COG1621 Beta-fructosidases (levanase/invertase) 0.593352 viridans - COG2035 Predicted membrane protein Cluster 131 ----------------------------------------------------------- 0.641564 serodiagnosis - COG1659 Uncharacterized protein, linocin/CFP29 homolog Cluster 132 ----------------------------------------------------------- 0.641528 hydroxylation - COG3655 Predicted transcriptional regulator 0.636074 arthrobacter - COG3655 Predicted transcriptional regulator 0.599637 prolyl - COG3655 Predicted transcriptional regulator 0.596008 thermophilus - COG3655 Predicted transcriptional regulator 0.587164 amylase - COG3655 Predicted transcriptional regulator 0.586838 valine - COG3655 Predicted transcriptional regulator 0.576732 methyltransferases - COG1983 Putative stress-responsive transcriptional regulator 0.569283 regulon - COG1440 Phosphotransferase system cellobiose-specific component IIB Cluster 133 ----------------------------------------------------------- 0.641193 capsid - COG4194 Predicted membrane protein Cluster 134 ----------------------------------------------------------- 0.640968 serotyping - COG4283 Uncharacterized conserved protein 0.594019 serotyping - NOG09371 non supervised orthologous group 0.582996 serotyping - COG4443 Uncharacterized protein conserved in bacteria Cluster 135 ----------------------------------------------------------- 0.640735 enterobacter - COG0386 Glutathione peroxidase Cluster 136 ----------------------------------------------------------- 0.640543 outbreak - COG4974 Site-specific recombinase XerD 0.601255 injection - COG1278 Cold shock proteins 0.577421 outbreak - COG1278 Cold shock proteins Cluster 137 ----------------------------------------------------------- 0.639569 disinfectant - COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit 0.639569 disinfectant - COG5405 ATP-dependent protease HslVU (ClpYQ), peptidase subunit 0.602051 disinfection - COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit 0.602051 disinfection - COG5405 ATP-dependent protease HslVU (ClpYQ), peptidase subunit Cluster 138 ----------------------------------------------------------- 0.639238 chromophore - COG2066 Glutaminase Cluster 139 ----------------------------------------------------------- 0.639167 enterotoxin - COG1528 Ferritin-like protein 0.624849 enterocolitis - COG1528 Ferritin-like protein 0.624187 toxigenic - COG1528 Ferritin-like protein 0.621832 metronidazole - COG1528 Ferritin-like protein 0.569765 stomach - COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family) 0.569318 enteritis - COG1528 Ferritin-like protein Cluster 140 ----------------------------------------------------------- 0.638943 replicon - COG3485 Protocatechuate 3,4-dioxygenase beta subunit 0.628995 assimilation - COG4674 Uncharacterized ABC-type transport system, ATPase component 0.596091 replicon - COG4913 Uncharacterized protein conserved in bacteria 0.593458 planta - COG5373 Predicted membrane protein 0.586975 homoserine - COG4674 Uncharacterized ABC-type transport system, ATPase component 0.582082 replicon - COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Cluster 141 ----------------------------------------------------------- 0.638781 regulon - COG1897 Homoserine trans-succinylase Cluster 142 ----------------------------------------------------------- 0.638686 dephosphorylation - COG0501 Zn-dependent protease with chaperone function 0.634433 mutagenesis - COG0501 Zn-dependent protease with chaperone function 0.608497 mutant - COG0501 Zn-dependent protease with chaperone function 0.588307 assembly - COG1226 Kef-type K+ transport systems, predicted NAD-binding component 0.576972 dephosphorylation - COG0330 Membrane protease subunits, stomatin/prohibitin homologs Cluster 143 ----------------------------------------------------------- 0.637332 sludge - COG1524 putative pyrophosphatase (Uncharacterized proteins of the AP superfamily) 0.598600 peptone - COG1524 putative pyrophosphatase (Uncharacterized proteins of the AP superfamily) 0.582299 xylose - COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases Cluster 144 ----------------------------------------------------------- 0.637070 counterimmunoelectrophoresis - COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes 0.630468 counterimmunoelectrophoresis - NOG09685 non supervised orthologous group Cluster 145 ----------------------------------------------------------- 0.636959 intoxication - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport 0.588850 intoxication - COG4929 Uncharacterized membrane-anchored protein Cluster 146 ----------------------------------------------------------- 0.636571 taxonomy - COG4320 Uncharacterized protein conserved in bacteria 0.635455 polyketide - COG4247 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) 0.621341 taxonomy - NOG09952 non supervised orthologous group 0.588309 chromophore - COG3861 Uncharacterized protein conserved in bacteria 0.584667 polyketide - NOG09952 non supervised orthologous group Cluster 147 ----------------------------------------------------------- 0.636477 glomerulonephritis - NOG09279 non supervised orthologous group 0.623007 counterimmunoelectrophoresis - NOG18016 non supervised orthologous group Cluster 148 ----------------------------------------------------------- 0.633848 glutamine - COG3339 Uncharacterized conserved protein 0.620449 hydrogenase - COG1669 Predicted nucleotidyltransferases 0.611519 periplasm - COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain 0.607000 holoenzyme - COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain 0.599554 chloroplast - COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain 0.589436 cytochrome - COG3339 Uncharacterized conserved protein 0.586628 sulphur - COG3339 Uncharacterized conserved protein 0.580148 vinelandii - COG3339 Uncharacterized conserved protein 0.573447 dichroism - COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain 0.573086 regulon - COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain 0.571922 flagellum - COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain 0.569942 ferredoxins - COG3339 Uncharacterized conserved protein Cluster 149 ----------------------------------------------------------- 0.633606 pharyngitis - COG2984 ABC-type uncharacterized transport system, periplasmic component 0.623064 glomerulonephritis - COG1101 ABC-type uncharacterized transport system, ATPase component 0.617653 tonsillitis - COG1101 ABC-type uncharacterized transport system, ATPase component 0.616887 pharyngitis - COG1101 ABC-type uncharacterized transport system, ATPase component 0.591444 viridans - COG1101 ABC-type uncharacterized transport system, ATPase component Cluster 150 ----------------------------------------------------------- 0.633254 polyketide - COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 0.616512 polyketide - COG4110 Uncharacterized protein involved in stress response 0.607531 polyketide - COG5276 Uncharacterized conserved protein 0.597351 polyketide - NOG06493 non supervised orthologous group 0.576920 polyketide - NOG08582 non supervised orthologous group Cluster 151 ----------------------------------------------------------- 0.633242 megaterium - COG2311 Predicted membrane protein 0.619515 megaterium - COG1904 Glucuronate isomerase 0.599609 megaterium - COG3546 Mn-containing catalase Cluster 152 ----------------------------------------------------------- 0.632833 rattus - COG2152 Predicted glycosylase Cluster 153 ----------------------------------------------------------- 0.631750 polymerases - COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) 0.614078 crystallization - COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 0.611352 stabilization - COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes 0.598975 sulphur - COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 0.598013 thermus - COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) 0.593730 guanine - COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) 0.592816 acceptor - COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 0.584484 biochemistry - COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 0.581926 dehydrogenase - COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 0.577280 regulon - COG1004 Predicted UDP-glucose 6-dehydrogenase 0.574773 thermostability - COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Cluster 154 ----------------------------------------------------------- 0.631276 vinelandii - COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis 0.623651 denitrificans - COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis 0.586371 azotobacter - COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis 0.570529 herbicide - COG4401 Chorismate mutase Cluster 155 ----------------------------------------------------------- 0.630932 betaine - COG1215 Glycosyltransferases, probably involved in cell wall biogenesis Cluster 156 ----------------------------------------------------------- 0.630557 lactation - COG3001 Fructosamine-3-kinase Cluster 157 ----------------------------------------------------------- 0.629595 dichroism - COG2105 Uncharacterized conserved protein 0.608165 glutamate - COG2105 Uncharacterized conserved protein 0.595185 oxidoreductase - COG2105 Uncharacterized conserved protein 0.592556 catalysis - COG2105 Uncharacterized conserved protein 0.579136 coenzyme - COG1541 Coenzyme F390 synthetase Cluster 158 ----------------------------------------------------------- 0.629525 implant - COG1566 Multidrug resistance efflux pump 0.627687 osteomyelitis - COG1566 Multidrug resistance efflux pump 0.608093 prosthesis - COG1566 Multidrug resistance efflux pump 0.598357 disinfectant - COG1671 Uncharacterized protein conserved in bacteria 0.574215 silicone - COG1566 Multidrug resistance efflux pump 0.572346 dermatitis - COG1566 Multidrug resistance efflux pump 0.569557 vegetation - COG1566 Multidrug resistance efflux pump Cluster 159 ----------------------------------------------------------- 0.628638 toxigenic - COG2035 Predicted membrane protein 0.619059 enterotoxin - COG2035 Predicted membrane protein Cluster 160 ----------------------------------------------------------- 0.627898 adhesin - COG0732 Restriction endonuclease S subunits 0.617011 adherence - COG0732 Restriction endonuclease S subunits 0.585965 hinton - COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Cluster 161 ----------------------------------------------------------- 0.627346 repression - COG0679 Predicted permeases 0.584508 constant - COG0679 Predicted permeases Cluster 162 ----------------------------------------------------------- 0.626914 tetanus - COG2932 Predicted transcriptional regulator 0.601360 fatality - COG2932 Predicted transcriptional regulator 0.594630 meningitis - COG2932 Predicted transcriptional regulator 0.589138 toxoid - COG2932 Predicted transcriptional regulator 0.582701 toxoid - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.578786 chemoprophylaxis - COG2932 Predicted transcriptional regulator 0.571377 fatality - COG2855 Predicted membrane protein 0.571019 tetanus - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.570100 fatality - COG4300 Predicted permease, cadmium resistance protein Cluster 163 ----------------------------------------------------------- 0.626726 histocompatibility - COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes 0.579790 suspicion - COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes 0.578398 ofloxacin - COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes 0.570038 monocyte - COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes 0.569269 regimen - COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Cluster 164 ----------------------------------------------------------- 0.626398 penicillin - COG3022 Uncharacterized protein conserved in bacteria 0.611151 benzylpenicillin - COG3022 Uncharacterized protein conserved in bacteria 0.573581 benzylpenicillin - COG3475 LPS biosynthesis protein Cluster 165 ----------------------------------------------------------- 0.626325 exopolysaccharide - COG3156 Type II secretory pathway, component PulK 0.620044 exopolysaccharide - COG3011 Uncharacterized protein conserved in bacteria 0.576479 vegetation - COG3011 Uncharacterized protein conserved in bacteria Cluster 166 ----------------------------------------------------------- 0.626281 prevention - COG2271 Sugar phosphate permease 0.603944 monocyte - COG2271 Sugar phosphate permease 0.597691 epidemic - COG2271 Sugar phosphate permease 0.582404 leukocytes - COG2271 Sugar phosphate permease 0.571075 hospitalization - COG4284 UDP-glucose pyrophosphorylase 0.569405 hospitalization - COG1114 Branched-chain amino acid permeases Cluster 167 ----------------------------------------------------------- 0.626260 exopolysaccharide - COG3652 Predicted outer membrane protein 0.624919 exopolysaccharide - COG4313 Protein involved in meta-pathway of phenol degradation 0.587210 biofilm - COG4323 Predicted membrane protein Cluster 168 ----------------------------------------------------------- 0.626088 acinetobacter - COG3182 Uncharacterized iron-regulated membrane protein 0.604993 acinetobacter - COG1469 Uncharacterized conserved protein 0.571602 acinetobacter - COG2851 H+/citrate symporter Cluster 169 ----------------------------------------------------------- 0.625542 pneumococcus - COG1322 Uncharacterized protein conserved in bacteria 0.572956 pharyngitis - COG1322 Uncharacterized protein conserved in bacteria 0.572395 pneumococcus - COG0625 Glutathione S-transferase Cluster 170 ----------------------------------------------------------- 0.625009 opsonin - COG1566 Multidrug resistance efflux pump Cluster 171 ----------------------------------------------------------- 0.624783 brucellosis - COG3553 Uncharacterized protein conserved in bacteria Cluster 172 ----------------------------------------------------------- 0.624583 vinelandii - COG0850 Septum formation inhibitor 0.623067 germination - COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases 0.579660 cellobiose - COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases 0.575632 barley - COG2894 Septum formation inhibitor-activating ATPase 0.573874 germination - COG2894 Septum formation inhibitor-activating ATPase 0.568539 potato - COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Cluster 173 ----------------------------------------------------------- 0.623992 benzylpenicillin - COG3819 Predicted membrane protein 0.623992 benzylpenicillin - COG3817 Predicted membrane protein Cluster 174 ----------------------------------------------------------- 0.623408 archaeon - COG2522 Predicted transcriptional regulator 0.613789 holliday - COG1856 Uncharacterized homolog of biotin synthetase 0.613789 holliday - COG2516 Biotin synthase-related enzyme 0.607848 holliday - COG1468 RecB family exonuclease 0.606456 holliday - COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.605587 thermus - COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 0.603750 holliday - NOG07117 non supervised orthologous group 0.601291 holliday - COG1857 Uncharacterized protein predicted to be involved in DNA repair 0.598671 catalysis - COG1468 RecB family exonuclease 0.585690 dichroism - COG1468 RecB family exonuclease 0.578728 holliday - COG2406 Protein distantly related to bacterial ferritins 0.570409 holliday - COG4911 Uncharacterized conserved protein 0.570387 starch - COG2163 Ribosomal protein L14E/L6E/L27E 0.569856 catalysis - COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) Cluster 175 ----------------------------------------------------------- 0.622219 starvation - COG4783 Putative Zn-dependent protease, contains TPR repeats 0.579456 regulon - COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Cluster 176 ----------------------------------------------------------- 0.621983 epidemic - COG4536 Putative Mg2+ and Co2+ transporter CorB Cluster 177 ----------------------------------------------------------- 0.621406 amoxicillin - COG1636 Uncharacterized protein conserved in bacteria Cluster 178 ----------------------------------------------------------- 0.621143 artery - COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA Cluster 179 ----------------------------------------------------------- 0.621079 betaine - COG0702 Predicted nucleoside-diphosphate-sugar epimerases 0.589895 starter - COG3153 Predicted acetyltransferase 0.574401 spoilage - COG3594 Fucose 4-O-acetylase and related acetyltransferases 0.569764 peptone - COG3594 Fucose 4-O-acetylase and related acetyltransferases Cluster 180 ----------------------------------------------------------- 0.620852 animal - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase 0.588540 animal - COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport Cluster 181 ----------------------------------------------------------- 0.620716 cholesterol - NOG17873 non supervised orthologous group Cluster 182 ----------------------------------------------------------- 0.620298 multiplication - COG3459 Cellobiose phosphorylase Cluster 183 ----------------------------------------------------------- 0.619924 taxonomy - COG3718 Uncharacterized enzyme involved in inositol metabolism 0.574419 taxonomy - COG3962 Acetolactate synthase Cluster 184 ----------------------------------------------------------- 0.619916 polyketide - COG3232 5-carboxymethyl-2-hydroxymuconate isomerase Cluster 185 ----------------------------------------------------------- 0.619674 bacteriocin - COG4331 Predicted membrane protein Cluster 186 ----------------------------------------------------------- 0.619452 dichroism - COG1514 2-5 RNA ligase 0.606794 aspartate - COG1514 2-5 RNA ligase 0.606204 glutamate - COG1514 2-5 RNA ligase Cluster 187 ----------------------------------------------------------- 0.619193 cereus - COG2382 Enterochelin esterase and related enzymes 0.613120 peptone - COG2807 Cyanate permease 0.608069 peptone - COG2382 Enterochelin esterase and related enzymes 0.577847 fermentation - COG0428 Predicted divalent heavy-metal cations transporter 0.571248 propionate - COG2807 Cyanate permease Cluster 188 ----------------------------------------------------------- 0.618885 thermostability - COG1586 S-adenosylmethionine decarboxylase 0.595767 hydrolysis - COG0421 Spermidine synthase 0.589428 aspartate - COG1980 Archaeal fructose 1,6-bisphosphatase 0.583296 crystal - COG1630 Uncharacterized protein conserved in archaea 0.582983 aspartate - COG0421 Spermidine synthase 0.577793 thermostability - COG1517 Uncharacterized protein predicted to be involved in DNA repair 0.575539 crystallization - COG0421 Spermidine synthase 0.573386 crystal - COG1517 Uncharacterized protein predicted to be involved in DNA repair Cluster 189 ----------------------------------------------------------- 0.618651 opsonin - NOG07935 non supervised orthologous group 0.607260 endophthalmitis - NOG07935 non supervised orthologous group 0.592581 endophthalmitis - COG4495 Uncharacterized protein conserved in bacteria 0.583862 endophthalmitis - COG3949 Uncharacterized membrane protein 0.577789 bacteraemia - NOG08620 non supervised orthologous group 0.576962 endophthalmitis - COG4270 Predicted membrane protein 0.570075 endophthalmitis - NOG08620 non supervised orthologous group Cluster 190 ----------------------------------------------------------- 0.618210 oxacillin - COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Cluster 191 ----------------------------------------------------------- 0.618083 tobacco - COG0467 RecA-superfamily ATPases implicated in signal transduction 0.610624 planta - COG0467 RecA-superfamily ATPases implicated in signal transduction 0.599186 carbon - COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family 0.598454 sulphur - COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family 0.579396 ferredoxin - COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family 0.569377 nitrogen - COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Cluster 192 ----------------------------------------------------------- 0.618081 debridement - COG2035 Predicted membrane protein 0.592298 immunodiffusion - COG2035 Predicted membrane protein Cluster 193 ----------------------------------------------------------- 0.617888 enterocolitis - COG3451 Type IV secretory pathway, VirB4 components 0.615835 colitis - COG3451 Type IV secretory pathway, VirB4 components 0.592823 enteritis - COG3451 Type IV secretory pathway, VirB4 components 0.587902 diarrhoea - COG3451 Type IV secretory pathway, VirB4 components Cluster 194 ----------------------------------------------------------- 0.617361 opsonin - COG2021 Homoserine acetyltransferase Cluster 195 ----------------------------------------------------------- 0.617124 malate - COG1910 Periplasmic molybdate-binding protein/domain 0.604216 succinate - COG1910 Periplasmic molybdate-binding protein/domain Cluster 196 ----------------------------------------------------------- 0.616236 repair - COG1341 Predicted GTPase or GTP-binding protein 0.612872 repair - COG1818 Predicted RNA-binding protein, contains THUMP domain 0.609814 repair - COG2174 Ribosomal protein L34E 0.602870 repair - COG1591 Holliday junction resolvase - archaeal type 0.602870 repair - COG2090 Uncharacterized protein conserved in archaea 0.601861 repair - COG1992 Uncharacterized conserved protein 0.594676 repair - COG1673 Uncharacterized protein conserved in archaea 0.592458 repair - COG1590 Uncharacterized conserved protein 0.584325 repair - COG2100 Predicted Fe-S oxidoreductase 0.576224 repair - COG1531 Uncharacterized protein conserved in archaea 0.575109 repair - COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN 0.574078 repair - COG3357 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon 0.573993 repair - COG1110 Reverse gyrase 0.571637 repair - COG2106 Uncharacterized conserved protein Cluster 197 ----------------------------------------------------------- 0.616176 granuloma - NOG08314 non supervised orthologous group 0.576979 hypersensitiveness - NOG10785 non supervised orthologous group Cluster 198 ----------------------------------------------------------- 0.616042 nitrogen - COG1348 Nitrogenase subunit NifH (ATPase) 0.616042 nitrogen - COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains 0.604232 nitrogen - COG2085 Predicted dinucleotide-binding enzymes 0.602328 nitrogenase - COG1348 Nitrogenase subunit NifH (ATPase) 0.602328 nitrogenase - COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains 0.596584 hydrogenase - COG4923 Uncharacterized conserved protein Cluster 199 ----------------------------------------------------------- 0.615894 benzylpenicillin - COG4929 Uncharacterized membrane-anchored protein Cluster 200 ----------------------------------------------------------- 0.615461 fluorescens - COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4 Cluster 201 ----------------------------------------------------------- 0.614944 protoplast - COG2514 Predicted ring-cleavage extradiol dioxygenase 0.579886 protoplast - COG3764 Sortase (surface protein transpeptidase) Cluster 202 ----------------------------------------------------------- 0.614931 sorbitol - COG3727 DNA G:T-mismatch repair endonuclease Cluster 203 ----------------------------------------------------------- 0.614882 dichroism - COG2509 Uncharacterized FAD-dependent dehydrogenases 0.597641 eubacteria - COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain 0.595047 eubacteria - COG4756 Predicted cation transporter 0.587020 hydrogenase - COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II 0.568506 glucosidase - COG1633 Uncharacterized conserved protein Cluster 204 ----------------------------------------------------------- 0.613847 stenotrophomonas - COG3661 Alpha-glucuronidase Cluster 205 ----------------------------------------------------------- 0.613792 arthrobacter - COG1610 Uncharacterized conserved protein 0.583116 denitrificans - COG2873 O-acetylhomoserine sulfhydrylase 0.568299 starch - COG1610 Uncharacterized conserved protein Cluster 206 ----------------------------------------------------------- 0.613687 cholera - COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 0.601428 cholera - COG2985 Predicted permease Cluster 207 ----------------------------------------------------------- 0.613480 megaterium - COG1873 Uncharacterized conserved protein Cluster 208 ----------------------------------------------------------- 0.613401 enteritidis - COG3238 Uncharacterized protein conserved in bacteria Cluster 209 ----------------------------------------------------------- 0.612839 haemin - COG2978 Putative p-aminobenzoyl-glutamate transporter 0.575549 septicaemia - COG2846 Regulator of cell morphogenesis and NO signaling Cluster 210 ----------------------------------------------------------- 0.612478 tumour - COG0562 UDP-galactopyranose mutase Cluster 211 ----------------------------------------------------------- 0.612427 intoxication - COG3007 Uncharacterized paraquat-inducible protein B Cluster 212 ----------------------------------------------------------- 0.612106 brucellosis - NOG04064 non supervised orthologous group Cluster 213 ----------------------------------------------------------- 0.611515 subunit - COG0062 unchar. protein often fused to putative sugar kinase [good one might be arabinose, often cell wall component of bacteria] (Uncharacterized conserved protein) 0.577602 ammonia - COG0402 Cytosine deaminase and related metal-dependent hydrolases 0.570590 glutamate - COG0402 Cytosine deaminase and related metal-dependent hydrolases Cluster 214 ----------------------------------------------------------- 0.611241 phosphoprotein - COG1963 Uncharacterized protein conserved in bacteria 0.576163 phosphoprotein - COG4401 Chorismate mutase Cluster 215 ----------------------------------------------------------- 0.610405 emission - COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit 0.606509 fluorescens - COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit 0.576991 fluorescens - COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit Cluster 216 ----------------------------------------------------------- 0.610402 acinetobacter - COG4728 Uncharacterized protein conserved in bacteria 0.572861 piperacillin - COG4267 Predicted membrane protein Cluster 217 ----------------------------------------------------------- 0.609233 megaterium - COG1514 2-5 RNA ligase Cluster 218 ----------------------------------------------------------- 0.608917 haemolysin - COG3242 Uncharacterized protein conserved in bacteria Cluster 219 ----------------------------------------------------------- 0.608046 antibiotic - COG0208 Ribonucleotide reductase, beta subunit Cluster 220 ----------------------------------------------------------- 0.608037 fructose - COG3472 Uncharacterized conserved protein 0.600819 valine - COG3472 Uncharacterized conserved protein 0.583634 dehydratase - COG3472 Uncharacterized conserved protein Cluster 221 ----------------------------------------------------------- 0.606956 hydroxylation - COG2807 Cyanate permease Cluster 222 ----------------------------------------------------------- 0.606805 meningitis - COG2919 Septum formation initiator Cluster 223 ----------------------------------------------------------- 0.606674 lecithinase - NOG09823 non supervised orthologous group 0.573625 lecithinase - NOG16465 non supervised orthologous group Cluster 224 ----------------------------------------------------------- 0.606619 serogroups - COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 0.595430 serogroup - COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Cluster 225 ----------------------------------------------------------- 0.606225 azithromycin - COG2984 ABC-type uncharacterized transport system, periplasmic component Cluster 226 ----------------------------------------------------------- 0.605128 glucuronidase - COG4928 Predicted P-loop ATPase 0.586605 potato - COG3135 Uncharacterized protein involved in benzoate metabolism Cluster 227 ----------------------------------------------------------- 0.605026 xylose - COG3394 Uncharacterized protein conserved in bacteria Cluster 228 ----------------------------------------------------------- 0.604494 insect - COG3867 Arabinogalactan endo-1,4-beta-galactosidase 0.595142 insect - COG3963 Phospholipid N-methyltransferase 0.583592 kilobase - COG3963 Phospholipid N-methyltransferase 0.570497 insect - COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins Cluster 229 ----------------------------------------------------------- 0.604373 antibiotic - COG1620 L-lactate permease Cluster 230 ----------------------------------------------------------- 0.604303 aminopeptidase - COG2362 D-aminopeptidase Cluster 231 ----------------------------------------------------------- 0.603190 syndrome - COG1288 Predicted membrane protein 0.577042 institution - COG4475 Uncharacterized protein conserved in bacteria Cluster 232 ----------------------------------------------------------- 0.602072 hinton - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.600396 mueller - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases 0.575106 colonisation - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 233 ----------------------------------------------------------- 0.601399 fermentation - NOG06509 non supervised orthologous group 0.583777 fermentation - COG1479 Uncharacterized conserved protein Cluster 234 ----------------------------------------------------------- 0.600963 seropositivity - COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains 0.600665 seropositivity - COG0823 Periplasmic component of the Tol biopolymer transport system Cluster 235 ----------------------------------------------------------- 0.600641 mucosa - COG3059 Predicted membrane protein Cluster 236 ----------------------------------------------------------- 0.599381 ribosome - COG4933 Uncharacterized conserved protein Cluster 237 ----------------------------------------------------------- 0.599208 eubacteria - COG2971 Predicted N-acetylglucosamine kinase Cluster 238 ----------------------------------------------------------- 0.599154 thiamine - COG3435 Gentisate 1,2-dioxygenase 0.581103 toluene - COG3435 Gentisate 1,2-dioxygenase Cluster 239 ----------------------------------------------------------- 0.598617 penicillin - COG3764 Sortase (surface protein transpeptidase) Cluster 240 ----------------------------------------------------------- 0.598466 vancomycin - COG2978 Putative p-aminobenzoyl-glutamate transporter 0.592786 implant - COG2846 Regulator of cell morphogenesis and NO signaling 0.591531 cefazolin - COG2978 Putative p-aminobenzoyl-glutamate transporter 0.577216 coagulase - COG2978 Putative p-aminobenzoyl-glutamate transporter 0.570462 enterobacteriaceae - COG2978 Putative p-aminobenzoyl-glutamate transporter Cluster 241 ----------------------------------------------------------- 0.598089 catechol - COG4394 Uncharacterized protein conserved in bacteria Cluster 242 ----------------------------------------------------------- 0.598077 coagulation - COG3634 Alkyl hydroperoxide reductase, large subunit Cluster 243 ----------------------------------------------------------- 0.597599 abscess - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase 0.577044 illness - COG3010 Putative N-acetylmannosamine-6-phosphate epimerase Cluster 244 ----------------------------------------------------------- 0.595682 cellobiose - COG1524 putative pyrophosphatase (Uncharacterized proteins of the AP superfamily) Cluster 245 ----------------------------------------------------------- 0.595382 lactamase - COG1755 putative integral membrane (prev: Uncharacterized protein conserved in bacteria) Cluster 246 ----------------------------------------------------------- 0.595309 silicone - COG0423 Glycyl-tRNA synthetase (class II) Cluster 247 ----------------------------------------------------------- 0.595263 serotyping - COG0602 Organic radical activating enzymes Cluster 248 ----------------------------------------------------------- 0.594925 alfalfa - COG3535 Uncharacterized conserved protein 0.593698 alfalfa - COG4091 Predicted homoserine dehydrogenase 0.592416 denitrificans - COG4912 Predicted DNA alkylation repair enzyme 0.592272 tomato - COG4091 Predicted homoserine dehydrogenase 0.580430 denitrificans - COG4748 Uncharacterized conserved protein 0.575595 lactose - COG2848 Uncharacterized conserved protein 0.575255 starch - COG2848 Uncharacterized conserved protein 0.572833 denitrificans - NOG08857 non supervised orthologous group Cluster 249 ----------------------------------------------------------- 0.594173 fermentation - NOG08394 non supervised orthologous group Cluster 250 ----------------------------------------------------------- 0.594079 intestine - COG1904 Glucuronate isomerase Cluster 251 ----------------------------------------------------------- 0.593953 enterobacteriaceae - COG1434 Uncharacterized conserved protein 0.573314 ceftazidime - COG1434 Uncharacterized conserved protein Cluster 252 ----------------------------------------------------------- 0.593625 serogroup - COG3567 Uncharacterized protein conserved in bacteria 0.593625 serogroup - COG3566 Uncharacterized protein conserved in bacteria Cluster 253 ----------------------------------------------------------- 0.593460 acinetobacter - COG3184 Uncharacterized protein conserved in bacteria Cluster 254 ----------------------------------------------------------- 0.592268 vacuum - COG1803 Methylglyoxal synthase Cluster 255 ----------------------------------------------------------- 0.591944 coliforms - COG0679 Predicted permeases Cluster 256 ----------------------------------------------------------- 0.591926 ciprofloxacin - COG1566 Multidrug resistance efflux pump 0.588917 epidemic - COG3027 Uncharacterized protein conserved in bacteria 0.574252 killing - COG1566 Multidrug resistance efflux pump Cluster 257 ----------------------------------------------------------- 0.591815 device - COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold Cluster 258 ----------------------------------------------------------- 0.591523 metronidazole - NOG13102 non supervised orthologous group Cluster 259 ----------------------------------------------------------- 0.591437 arthrobacter - COG1192 ATPases involved in chromosome partitioning 0.585584 monooxygenase - COG1192 ATPases involved in chromosome partitioning 0.569420 filament - COG1192 ATPases involved in chromosome partitioning Cluster 260 ----------------------------------------------------------- 0.591018 sludge - COG1683 Uncharacterized conserved protein 0.586395 sludge - COG2873 O-acetylhomoserine sulfhydrylase 0.584011 lecithinase - COG1683 Uncharacterized conserved protein Cluster 261 ----------------------------------------------------------- 0.590291 agglutination - COG0849 Actin-like ATPase involved in cell division Cluster 262 ----------------------------------------------------------- 0.590238 xylose - COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC 0.576837 xylose - COG1276 Putative copper export protein Cluster 263 ----------------------------------------------------------- 0.590215 microflora - COG1086 (very probably involved in lipopolysaccharide / capsule formation) Predicted nucleoside-diphosphate sugar epimerases Cluster 264 ----------------------------------------------------------- 0.589778 ampicillin - COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Cluster 265 ----------------------------------------------------------- 0.589406 microflora - NOG14203 non supervised orthologous group Cluster 266 ----------------------------------------------------------- 0.589066 neutropenia - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 0.571050 endocarditis - COG4300 Predicted permease, cadmium resistance protein Cluster 267 ----------------------------------------------------------- 0.589037 biotransformation - COG1129 ABC-type sugar transport system, ATPase component Cluster 268 ----------------------------------------------------------- 0.588814 fermentation - COG4320 Uncharacterized protein conserved in bacteria 0.586849 fermentation - COG3940 Predicted beta-xylosidase Cluster 269 ----------------------------------------------------------- 0.588778 pathogenicity - COG0698 Ribose 5-phosphate isomerase RpiB Cluster 270 ----------------------------------------------------------- 0.588207 infection - COG1862 Preprotein translocase subunit YajC Cluster 271 ----------------------------------------------------------- 0.587671 flagellin - COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Cluster 272 ----------------------------------------------------------- 0.587003 regulator - COG0668 Small-conductance mechanosensitive channel Cluster 273 ----------------------------------------------------------- 0.586902 tumour - COG4766 Ethanolamine utilization protein Cluster 274 ----------------------------------------------------------- 0.586773 serogroup - NOG14186 non supervised orthologous group 0.581029 serogroup - COG3779 Uncharacterized protein conserved in bacteria Cluster 275 ----------------------------------------------------------- 0.586764 gonorrhoeae - COG3310 Uncharacterized protein conserved in bacteria Cluster 276 ----------------------------------------------------------- 0.586748 neonate - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Cluster 277 ----------------------------------------------------------- 0.586316 sulfamethoxazole - NOG04064 non supervised orthologous group Cluster 278 ----------------------------------------------------------- 0.586023 cefaclor - COG0602 Organic radical activating enzymes 0.578922 hinton - COG0602 Organic radical activating enzymes 0.576406 mueller - COG0602 Organic radical activating enzymes Cluster 279 ----------------------------------------------------------- 0.584938 disinfection - COG1705 Muramidase (flagellum-specific) 0.574847 disinfectant - COG1705 Muramidase (flagellum-specific) Cluster 280 ----------------------------------------------------------- 0.584844 exopolysaccharide - COG3762 Predicted membrane protein 0.577570 vegetation - COG4536 Putative Mg2+ and Co2+ transporter CorB Cluster 281 ----------------------------------------------------------- 0.584397 maltose - COG0270 Site-specific DNA methylase Cluster 282 ----------------------------------------------------------- 0.584301 device - COG2223 Nitrate/nitrite transporter Cluster 283 ----------------------------------------------------------- 0.583729 homoserine - COG2318 Uncharacterized protein conserved in bacteria Cluster 284 ----------------------------------------------------------- 0.583280 opsonization - COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Cluster 285 ----------------------------------------------------------- 0.582815 glucuronidase - NOG05054 non supervised orthologous group Cluster 286 ----------------------------------------------------------- 0.582492 flagellum - COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB 0.580059 flagellin - COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB 0.568471 succinate - COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Cluster 287 ----------------------------------------------------------- 0.582428 trimethoprim - COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components 0.573415 trimethoprim - COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Cluster 288 ----------------------------------------------------------- 0.582030 aspiration - COG2846 Regulator of cell morphogenesis and NO signaling Cluster 289 ----------------------------------------------------------- 0.581076 multilocus - COG4283 Uncharacterized conserved protein Cluster 290 ----------------------------------------------------------- 0.580891 aerosol - COG4413 Urea transporter Cluster 291 ----------------------------------------------------------- 0.580783 seropositivity - COG1298 Flagellar biosynthesis pathway, component FlhA 0.580783 seropositivity - COG1157 Flagellar biosynthesis/type III secretory pathway ATPase 0.580783 seropositivity - COG1377 Flagellar biosynthesis pathway, component FlhB 0.580783 seropositivity - COG1338 Flagellar biosynthesis pathway, component FliP Cluster 292 ----------------------------------------------------------- 0.580437 exopolysaccharide - COG0246 Mannitol-1-phosphate/altronate dehydrogenases Cluster 293 ----------------------------------------------------------- 0.579796 toxoid - NOG09685 non supervised orthologous group 0.569285 toxoid - NOG16997 non supervised orthologous group Cluster 294 ----------------------------------------------------------- 0.579082 disinfectant - COG0714 MoxR-like ATPases Cluster 295 ----------------------------------------------------------- 0.578962 vaccinees - COG0321 Lipoate-protein ligase B 0.575897 vaccinees - COG0354 Predicted aminomethyltransferase related to GcvT 0.569556 vaccinees - COG1949 Oligoribonuclease (3->5 exoribonuclease) Cluster 296 ----------------------------------------------------------- 0.578714 moraxella - COG2851 H+/citrate symporter Cluster 297 ----------------------------------------------------------- 0.578607 germination - COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain Cluster 298 ----------------------------------------------------------- 0.578065 dichroism - COG0071 Molecular chaperone (small heat shock protein) 0.569188 regulator - COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 Cluster 299 ----------------------------------------------------------- 0.577727 fermentation - COG3340 Peptidase E Cluster 300 ----------------------------------------------------------- 0.577467 methyltransferase - COG2834 Outer membrane lipoprotein-sorting protein 0.570369 isomerase - COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain 0.570369 isomerase - COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Cluster 301 ----------------------------------------------------------- 0.576554 planta - COG3492 Uncharacterized protein conserved in bacteria 0.571764 transcript - COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing 0.568155 transcript - COG3211 Predicted phosphatase Cluster 302 ----------------------------------------------------------- 0.576322 fermentation - COG3842 ABC-type spermidine/putrescine transport systems, ATPase components Cluster 303 ----------------------------------------------------------- 0.576007 emission - COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component Cluster 304 ----------------------------------------------------------- 0.575623 kilobase - COG3822 ABC-type sugar transport system, auxiliary component Cluster 305 ----------------------------------------------------------- 0.575394 lactose - COG2244 Membrane protein involved in the export of O-antigen and teichoic acid Cluster 306 ----------------------------------------------------------- 0.574580 peritonitis - COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Cluster 307 ----------------------------------------------------------- 0.574478 cytotoxin - COG0062 unchar. protein often fused to putative sugar kinase [good one might be arabinose, often cell wall component of bacteria] (Uncharacterized conserved protein) Cluster 308 ----------------------------------------------------------- 0.574199 hinton - COG0786 Na+/glutamate symporter 0.568883 colonisation - COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Cluster 309 ----------------------------------------------------------- 0.572996 methyltransferases - COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins 0.571814 xylanase - COG3409 Putative peptidoglycan-binding domain-containing protein Cluster 310 ----------------------------------------------------------- 0.572594 resurgence - COG3884 Acyl-ACP thioesterase Cluster 311 ----------------------------------------------------------- 0.572562 diarrhoea - NOG26252 non supervised orthologous group Cluster 312 ----------------------------------------------------------- 0.571787 biotransformation - COG3655 Predicted transcriptional regulator Cluster 313 ----------------------------------------------------------- 0.571417 reactor - NOG08380 non supervised orthologous group Cluster 314 ----------------------------------------------------------- 0.570950 sewage - NOG26813 non supervised orthologous group Cluster 315 ----------------------------------------------------------- 0.570776 imipenem - COG1636 Uncharacterized protein conserved in bacteria Cluster 316 ----------------------------------------------------------- 0.570670 polysaccharide - COG2893 Phosphotransferase system, mannose/fructose-specific component IIA Cluster 317 ----------------------------------------------------------- 0.570315 complication - COG2181 Nitrate reductase gamma subunit Cluster 318 ----------------------------------------------------------- 0.570164 kilobase - COG0293 23S rRNA methylase Cluster 319 ----------------------------------------------------------- 0.569731 debridement - COG1024 Enoyl-CoA hydratase/carnithine racemase Cluster 320 ----------------------------------------------------------- 0.569223 polysaccharide - COG3598 RecA-family ATPase Cluster 321 ----------------------------------------------------------- 0.569051 sulfamethoxazole - COG3104 Dipeptide/tripeptide permease Cluster 322 ----------------------------------------------------------- 0.568913 immunodiffusion - COG4478 Predicted membrane protein Cluster 323 ----------------------------------------------------------- 0.568251 implantation - COG0011 Uncharacterized conserved protein