The WW domain: a protein module that binds proline-rich or proline-containing ligands

Peer Bork@EMBL-Heidelberg.DE or Marius Sudol@mssm.edu
Fax (Bork) +49 6221 387-517 or Fax (Sudol) +1 212 996-7214

Content of the Web Page:

• Definition of the WW domain and a brief summary of its function
• Original manual alignment of the WW domain sequences
• Automatically generated multiple alignment, updated constantly through the SMART's Sequence Alerting System
• Modular structure of selected proteins that contain WW domain(s)
• Molmol figures of WW domains and complexes with 'PDB' coordinates (help)
• Topview of YAP65-WW: peptide complex
• Pin1-WW domain
(r)
• FBP28-WW
(r)
• YQJ8-WW
(r)
• Dystrophin WW domain in complex with beta-dystroglycan peptide
(free or complex))
• Pin1 terminal WW domain in complex with a doubly phosphorilated peptide CTD repeat
(r)
• Classification of WW domains based on ligand specificity
• Representative structures of WW domains based on their sequences.
• Selected references with a brief comment on their relative significance