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Lactococcus A phages predict ACLF while Enterococcus B phages predict bacterial infection in decompensated cirrhosis.
Van Espen L, Brol MJ, Close L, Schierwagen R, Gu W,
Keller MI, Balogh B,
Fullam A, De Coninck L, Nakamura T,
Kuhn M,
Bork P, Laleman W, Bajaj JS, Papp M, Schnabl B, Trebicka J, Matthijnssens J, MICROB-PREDICT
As portal hypertension progresses in cirrhosis, bacterial translocation across a compromised gut barrier leads to endotoxemia, systemic inflammation and immune dysfunction. Gut phages play a key role in these processes by influencing bacteria-host interactions. This study explores the role of the human gut virome in acute decompensation of cirrhosis and acute-on-chronic liver failure (ACLF).