STEP 4
Co-abundances of proteins were calculated as Pearson correlations between protein abundances across individuals. As a control proteins that were not part of any complex assembly were randomly assigned into artificial complexes and cross-correlated as well (Figure S2B). In addition, the data was also permuted and proteins subunits were again tested for co-abundance using Pearson correlation (Figure S2B). The Mann-Whitney U-test was applied to assess significance.
complex-mapped and -filtered proteomics data from Battle et al. (2015), Science (Human Individuals)
complex_filtered_battle_ribo.tsv.gz (4.9MB)complex-mapped and -filtered ribosome profiling data from Battle et al. (2015), Science (Human Individuals)
complex_filtered_battle_rna.tsv.gz (4.9MB)complex-mapped and -filtered RNAseq data from Battle et al. (2015), Science (Human Individuals)
complex_filtered_gygi1.tsv.gz (2.2MB)complex-mapped and -filtered proteomics data from Chick et al. (2016), Nature (Founder Mouse strains, MS-proteomics)
complex_filtered_gygi2.tsv.gz (3.9MB)complex-mapped and -filtered RNAseq data from Chick et al. (2016), Nature (Founder Mouse strains, RNA-seq)
complex_filtered_gygi3.tsv.gz (2.8MB)complex-mapped and -filtered proteomics data from Chick et al. (2016), Nature (Founder Mouse strains, MS-proteomics)
complex_filtered_mann.tsv.gz (3.7MB)complex-mapped and -filtered proteomics data from Geiger et al.(2012), Mol Cell Proteomics (Human Cell Types)
complex_filtered_tcga_breast.tsv.gz (2.2MB)complex-mapped and -filtered proteomics data from Mertins et al. (2016), Nature (TCGA Breast Cancer)
complex_filtered_tcga_color.tsv.gz (1.3MB)complex-mapped and -filtered proteomics data from Roumeliotis et al. (2017),Cell (TCGA Colorectal Cancer)
complex_filtered_tcga_ovarian.tsv.gz (2.9MB)complex-mapped and -filtered proteomics data from Zhang et al. (2016), Cellf (TCGA Ovarian Cancer)
Python code required for reshuffling datasets, complexes and calculating correlation values.
Underlying data for Supplementary Figure 2b
Supplementary Figure 2b