This page provides information on WW domains. 
  Please forward suggestions/comments/correction to
  Peer Bork  or Marius Sudol 

        Peer.Bork@embl.org or sudol@rockvax.rockefeller.edu

• alignment
• 1D cartoon showing the location of WW domains in the respective proteins
• PROSITE documentation
• SWISSPROT proteins annotated to contain WW

Short progress headlines

• The 3D structure of YAP WW with and without bound peptide has been solved by NMR.
• Various WW domains have been expressed and ligand-binding studies are under way.
• The major binding theme appears to be a proline dipeptide followed by an aromate (e.g. (AP)PP(AP)Y in YAP).
• WW domains have been shown to compete with SH3 domains for several substrates.
• WW-ligand interaction appears to be criticla in several diseases including muscular dystrophy and Liddle's syndrome.
• The characterisation of several proteins containing WW is progressing (e.g. RSP5, a ubiquitin ligase or the bAPP-binding protein FE65).

• creation date: December 15, 1994
• last sequence update: April 15, 1996
• last modification: April 20, 1996