STEP 14

Summarizing effect size estimations of sex- and diet on modules

In this step the estimations calculated in Step12 are summarized and visualized in Figure 6a. The visualization allows assessing the distribution of the overall effect of sex, diet and the cumulative effect (sex + diet) on protein abundance variation (all proteins), as well as abundance and stoichiometry variation of modules, including protein complexes and pathways with highly co-varying protein members.

Data/Code Requirements for downloading

protein_variation.tsv.gz (230KB)

output file from machine-learning setup, summarizing variance for all proteins

gygi3_complex_quant_data_all_multi_covariate_moduleSpecific_COMBINEDEFFECT.tsv.gz (33KB)

output file from combined multi-variate analysis, summarizing R2 for module abundances

gygi3_complex_quant_data_all_multi_covariate_subunitSpecific_COMBINEDEFFECT.tsv.gz (106KB)

output file from combined multi-variate analysis, summarizing R2 for module subunit abundances

gygi3_complex_quant_diet_data_all_multi_covariate_moduleSpecific_empiricalFDR.tsv.gz (46.5KB)

output file from multi-variate analysis (co-variate: diet), summarizing R2 for module abundances

gygi3_complex_quant_diet_data_all_multi_covariate_subunitSpecific_empiricalFDR.tsv.gz (169KB)

output file from multi-variate analysis (co-variate: diet), summarizing R2 for module subunit abundances

gygi3_complex_quant_sex_data_all_multi_covariate_moduleSpecific_empiricalFDR.tsv.gz (46KB)

output file from multi-variate analysis (co-variate: sex), summarizing R2 for module abundances

gygi3_complex_quant_sex_data_all_multi_covariate_subunitSpecific_empiricalFDR.tsv.gz (171KB)

output file from multi-variate analysis (co-variate: sex), summarizing R2 for module subunit abundances

gygi3_complex_stoichiometry_data_all_multi_covariate_moduleSpecific_COMBINEDEFFECT.tsv.gz (32KB)

output file from combined multi-variate analysis, summarizing R2 for module stoichiometries

gygi3_complex_stoichiometry_data_all_multi_covariate_subunitSpecific_COMBINEDEFFECT.tsv.gz (106KB)

output file from combined multi-variate analysis, summarizing R2 for module subunit stoichiometries

gygi3_complex_stoichiometry_diet_data_all_multi_covariate_moduleSpecific_empiricalFDR.tsv.gz (45KB)

output file from multi-variate analysis (co-variate: diet), summarizing R2 for module stoichiometries

gygi3_complex_stoichiometry_diet_data_all_multi_covariate_subunitSpecific_empiricalFDR.tsv.gz (167KB)

output file from multi-variate analysis (co-variate: diet), summarizing R2 for module subunit stoichiometries

gygi3_complex_stoichiometry_sex_data_all_multi_covariate_moduleSpecific_empiricalFDR.tsv.gz (44.8KB)

output file from multi-variate analysis (co-variate: sex), summarizing R2 for module stoichiometries

gygi3_complex_stoichiometry_sex_data_all_multi_covariate_subunitSpecific_empiricalFDR.tsv.gz (169KB)

output file from multi-variate analysis (co-variate: sex), summarizing R2 for module subunit stoichiometries

Download all input data for this step here (2.86MB)

wp_step14_code.py

Python code required for summarizing effect sizes.

output_step14.zip (28MB)

underlying data for Figure 6a

Figure 6a