Computational Pipeline

In this step original datasets derived from the yeast-related publications illustrated in the Computational Pipeline are mapped to yeast protein IDs (uniprot, SGD identifiers, Gene Symbol...) and modules. Protein-protein interactions were obtained from the STRING database (version 10.5); interactions were considered to exist if the (STRING) combined score > 0, to be confident if the combined score > 0.5 (Figure S1), and high-confidence interactions if the combined score > 0.7. The database of complexes was extracted from the work of Benschop et al. (2010), and quantified proteins from all published datasets considered for the analysis were mapped accordingly. Pathways were obtained from https://pathway.yeastgenome.org.