STEP 5
For all datasets considered for the ROC-analysis (Step 6), the distribution of Pearson correlation coefficients for protein-protein pairs with STRING interaction score > 700 (combined score), known interaction (combined score >0) and random protein-protein pairs is analyzed. The Mann-Whitney U-test was used to assess significance of the respective shifts.
proteomics data from Battle et al. (2015), Science (Human Individuals)
dataset_battle_ribo_remapped.tsv.gz (27MB)cribosome profiling data from Battle et al. (2015), Science (Human Individuals)
dataset_battle_rna_remapped.tsv.gz (28MB)RNAseq data from Battle et al. (2015), Science (Human Individuals)
dataset_gygi1_remapped.tsv.gz (9MB)proteomics data from Chick et al. (2016), Nature (Founder Mouse strains, MS-proteomics)
dataset_gygi2_remapped.tsv.gz (25MB)RNAseq data from Chick et al. (2016), Naturef (DO Mouse strains, RNAseq)
dataset_gygi3_remapped.tsv.gz (12.5MB)proteomics data from Chick et al. (2016), Nature (DO Mouse strains, MS-proteomics)
dataset_mann_all_log2_remapped.tsv.gz (15MB)proteomics data from Geiger et al. (2012), Mol Cell Proteomics (Human Cell Types)
dataset_tiannan_remapped.tsv.gz (4.8MB)proteomics data from Guo et al. (2012), Nature Medicine (Human Kidney Cells)
dataset_tcga_breast_remapped.tsv.gz (9.6MB)proteomics data from Mertins et al. (2016), Nature (TCGA Breast Cancer)
dataset_coloCa_remapped.tsv.gz (4.3MB)proteomics data from Roumeliotis et al. (2017),Cell (TCGA Colorectal Cancer)
dataset_tcga_ovarian_remapped.tsv.gz (11MB)proteomics data from Zhang et al. (2016), Cell (TCGA Ovarian Cancer)
dataset_bxdMouse_remapped.tsv.gz (2MB)proteomics data from Williams et al. (2016), Science (BXD Mouse Strains)
string_data.zip (155MB)STRING interaction data for human and mice, v10.5
Python code required for calculation co-variation of STRING-connected protein pairs.
Underlying data for Supplementary Figure 1
Supplementary Figure 1